Citation: Xiang Wang, Cheng Ding, Ziwen Zhang, Chunlin Li, Dongmiao Cao, Linjing Zhao, Guoying Deng, Yu Luo, Chunping Yuan, Jie Lu, Xijian Liu. Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction[J]. Chinese Chemical Letters, ;2023, 34(7): 107951. doi: 10.1016/j.cclet.2022.107951 shu

Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction

Xiang Wang ^{a, 1} ,
Cheng Ding ^{b, 1} ,
Ziwen Zhang ^{a, 1} ,
Chunlin Li ^c ,
Dongmiao Cao ^a ,
Linjing Zhao ^a ,
Guoying Deng ^c ,
Yu Luo ^a ,
Chunping Yuan ^a ,
Jie Lu ^a ,
Xijian Liu ^{a, *,}

a.
School of Chemistry and Chemical Engineering, Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai 201620, China
b.
Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China
c.
Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China

liuxijian@sues.edu.cn

Received Date: 22 July 2022
Revised Date: 17 October 2022
Accepted Date: 23 October 2022
Available Online: 26 October 2022

Figures(4)

Diabetic patients often have problems such as residual tumor and wound infection after tumor resection, causing severe clinical problems. It is urgent to develop effective therapies to reach oncotherapy/anti-infection/promotion of wound healing combined treatment. Herein, we propose CS/MnO₂-GOx (CMGOx) nanocatalysts for the specific catalytic generation of ^•OH to inhibit tumors and bacteria in a hyperglycemic environment. The good biocompatible chitosan (CS), as a carrier for the catalyst, exhibits excellent antibacterial effect as well as promotes wound healing. Glucose oxidase (GOx) is loaded on the surface of CS nanoparticles to generate H₂O₂ and gluconic acid by consuming glucose (starvation therapy, ST) and O₂. The MnO₂ depletes glutathione (GSH) to produce Mn²⁺, amplifying oxidative stress and further promoting the activity of Mn²⁺-mediated Fenton-like reaction to produce ^•OH (chemodynamic therapy, CDT) in weak acidic environment. Moreover, the produced gluconic acid lowers the pH of the environment, enhancing chemodynamic therapy (ECDT). The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT. The MnO₂ nanoparticles at neutral environment decomposes H₂O₂ into O₂, which cooperate with CS to promote healing. The self-enhanced cascade reaction of CMGOx in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing, offering a promising integrated treatment for diabetic patients after tumor surgical resection.
- Self-cascade reaction,
- Starvation therapy,
- Chemodynamic therapy,
- Antitumor,
- Antibacterial,
- Wound healing
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