Citation: Huifang Su, Tao Xie, Yong U. Liu, Yuhan Cui, Wei Wen, Ben Zhong Tang, Wei Qin. Facile synthesis of ultrabright luminogens with specific lipid droplets targeting feature for in vivo two-photon fluorescence retina imaging[J]. Chinese Chemical Letters, ;2023, 34(6): 107949. doi: 10.1016/j.cclet.2022.107949 shu

Facile synthesis of ultrabright luminogens with specific lipid droplets targeting feature for in vivo two-photon fluorescence retina imaging

Huifang Su ^{a, 1,*,} ,
Tao Xie ^{d, 1} ,
Yong U. Liu ^d ,
Yuhan Cui ^e ,
Wei Wen ^a ,
Ben Zhong Tang ^{c, *,} ,
Wei Qin ^{b, *,}

a.
Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
b.
Medical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
c.
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen 518172, China
d.
Laboratory for Neuroscience in Health and Disease, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China
e.
School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China

suhuif@mail2.sysu.edu.cn

tangbenz@cuhk.edu.cn

qinwei@gdph.org.cn

Received Date: 1 September 2022
Revised Date: 17 October 2022
Accepted Date: 23 October 2022
Available Online: 1 November 2022

Figures(4)

The application of fluorescent probes for in vivo retinal imaging is of great importance, which could provide direct and crucial imaging evidence for a better understanding of common eye diseases. Herein, a group of bright organic luminogens with typical electron-donating (D) and electron-accepting (A) structures (abbreviated as LDs-BDM, LDs-BTM, and LDs-BHM) was synthesized through a simple single-step reaction. They were found to be efficient solid-state emitters with high fluorescence quantum yields of above 70% (e.g., 83.7% for LDs-BTM). Their light-emission properties could be tuned by the modulation of π-conjugation effect with methoxy groups at different substituent positions. Their resulting fluorescent nanoparticles (NPs) were demonstrated as specific lipid droplets (LDs) targeting probes with high brightness, good biocompatibility, and satisfactory photostability. LDs-BTM NPs with a large two-photon absorption cross section (σ₂ = 249 GM) were further utilized as ultrabright two-photon fluorescence (2PF) nanoprobes for in vivo retina imaging of live zebrafish by NIR excitation at an ultralow concentration (0.5 µmol/L). Integrated histological structures at the tissue level and corresponding fine details at the cellular level of the embryonic retina of live zebrafish were clearly demonstrated. This is the first report of using ultrabright LDs-targeting nanoprobes to accurately measure fine details in the retina with 2PF microscopic technique. These good results are anticipated to open up a new avenue in the development of efficient 2PF emitters for non-invasive bioimaging of living animals.
- Fluorescent probe,
- Lipid droplets (LDs),
- Two-photon fluorescence (2PF) imaging,
- Retina imaging
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