Citation: Ke Yang, Bowen Yu, Wei Liu, Zequn Zhang, Li Huang, Shaojing Zhao, Benhua Wang, Jianing Yi, Jun Yuan, Yingping Zou, Changwei Lin, Xiangzhi Song, Minhuan Lan. All-in-one phototheranostics based on BTP-4F-DMO nanoparticles for NIR-Ⅱ fluorescence/photoacoustic dual-mode imaging and combinational therapy[J]. Chinese Chemical Letters, ;2023, 34(6): 107889. doi: 10.1016/j.cclet.2022.107889 shu

All-in-one phototheranostics based on BTP-4F-DMO nanoparticles for NIR-Ⅱ fluorescence/photoacoustic dual-mode imaging and combinational therapy

Ke Yang ^{a, 1} ,
Bowen Yu ^{b, 1} ,
Wei Liu ^{a, 1} ,
Zequn Zhang ^b ,
Li Huang ^a ,
Shaojing Zhao ^a ,
Benhua Wang ^a ,
Jianing Yi ^{c, *,} ,
Jun Yuan ^{a, *,} ,
Yingping Zou ^a ,
Changwei Lin ^{b, *,} ,
Xiangzhi Song ^a ,
Minhuan Lan ^{a, *,}

a.
Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
b.
Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China
c.
Surgical Department of Breast and Thyroid Gland, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410083, China

yijianing@hunnu.edu.cn

junyuan@csu.edu.cn

linchangwei1987@csu.edu.cn

minhuanlan@csu.edu.cn

Received Date: 4 May 2022
Revised Date: 5 October 2022
Accepted Date: 5 October 2022
Available Online: 10 October 2022

Figures(4)

Various phototheranostics have recently been developed for phototherapy. Through proper molecular design, the photochemical and photophysical properties of these phototheranostics can be promoted. Herein, an acceptor-donor-acceptor (A-D-A)-structured dye, BTP-4F-DMO, was synthesized and prepared into water-soluble nanoparticles (NPs). The obtained BTP-4F-DMO NPs had strong absorption from 650 nm to 850 nm and a fluorescence emission peak at ~900 nm that tailed to ~1100 nm. The NPs showed a superhigh photothermal conversion efficiency of 90.5% ± 5% and could simultaneously generate ^•OH and ¹O₂ with a ¹O₂ generation quantum yield of 4.6% under 808 nm laser irradiation. Due to these advanced properties, BTP-4F-DMO NPs can switch the role of autophagy from pro-survival to pro-death, thereby further promoting cancer cell death. These features make BTP-4F-DMO NPs a promising multifunctional phototheranostic agent for NIR-Ⅱ fluorescence/photoacoustic dual-mode imaging-guided synergetic photodynamic/photothermal therapy. In general, this work provides a strategy for expanding the biomedical applications of organic A-D-A-structured phototheranostics.
- Photodynamic therapy,
- NIR-Ⅱ fluorescence imaging,
- Photothermal therapy,
- Photoacoustic imaging,
- Autophagy-induced death
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