Citation: Xiaotong Wang, Shizhu Chen, Yaru Jia, Kaihan Zhang, Lili Ma, Luwei Li, Xingjie Liang, Jinchao Zhang. Construction of AIEgen functionalized nanomicelles and their stability study through ‘seesaw-like’ fluorescence changes[J]. Chinese Chemical Letters, ;2023, 34(6): 107866. doi: 10.1016/j.cclet.2022.107866 shu

Construction of AIEgen functionalized nanomicelles and their stability study through ‘seesaw-like’ fluorescence changes

Xiaotong Wang ^{a, 1} ,
Shizhu Chen ^{a, 1} ,
Yaru Jia ^b ,
Kaihan Zhang ^c ,
Lili Ma ^a ,
Luwei Li ^{a, *,} ,
Xingjie Liang ^{b, *,} ,
Jinchao Zhang ^{a, *,}

a.
College of Chemistry and Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China
b.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
c.
Department of Chemistry, The University of Manchester, Manchester M13 9PL, United Kingdom

liluwei@hbu.edu.cn

liangxj@nanoctr.cn

jczhang6970@163.com

Received Date: 25 May 2022
Revised Date: 21 September 2022
Accepted Date: 28 September 2022
Available Online: 1 October 2022

Figures(6)

As nanocarriers, nanomicelles play vital roles in the toolbox of drug delivery. The stability of nanomicelles affects the nanomedicines’ bioactivity. Therefore, it is important to understand the stability of nanomicelles for further improvements. Here, we report a strategy to construct new nanomicelles (NM) by introducing aggregation-induced emission (AIE) functional group tetraphenylethylene (TPE) in the component polymer vitamin E (d-α-tocopheryl polyethylene glycol 1000 succinate) (TPGS). The stability of doxorubicin (DOX) loaded nanomicelles DOX@NM in different conditions was studied by fluorescence analysis. The fluorescence changes of DOX@NM are ‘seesaw-like’ when they transform between assembled and disassembled forms. In the assembled form, TPE gives emission from AIE effect, while in the disassembled form, the fluorescence of DOX is observed due to the disappearance of ACQ effect.
- Polymer nanomicelles,
- Aggregation-induced emission,
- Fluorescence ratio,
- Stability,
- Drug delivery system
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