Citation: Yangyang Wang, Weiqiang Jia, Jianwei Zhu, Ruxiang Xu, Yunfeng Lin. Tetrahedral framework nucleic acids promote cognitive impairment recovery post traumatic brain injury[J]. Chinese Chemical Letters, ;2023, 34(4): 107746. doi: 10.1016/j.cclet.2022.107746 shu

Tetrahedral framework nucleic acids promote cognitive impairment recovery post traumatic brain injury

Yangyang Wang ^{a, 1} ,
Weiqiang Jia ^{b, 1} ,
Jianwei Zhu ^a ,
Ruxiang Xu ^{a, *,} ,
Yunfeng Lin ^{c, *,}

a.
Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China
b.
Department of Neurosurgery, The First People's Hospital in Shuangliu District/West China Airport Hospital, Sichuan University, Chengdu 610299, China
c.
State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

xuruxiang1123@uestc.edu.cn

yunfenglin@scu.edu.cn

Received Date: 18 March 2022
Revised Date: 9 August 2022
Accepted Date: 10 August 2022
Available Online: 14 August 2022

Figures(5)

Cognitive impairment often occurs after post traumatic brain injury. In addition, recovery of cognitive impairment is largely dependent on spontaneous repair and the severity of secondary insult. The tetrahedral framework nucleic acid is a novel nanostructure has been shown to have a positive biological effect in promoting regeneration and anti-inflammation. To explore the treatment effect of tetrahedral framework nucleic acids for cognitive impairment recovery post traumatic brain injury, we established a mouse model of traumatic brain injury and verified the efficacy of tetrahedral framework nucleic acids in promoting cognitive impairment recovery post traumatic brain injury. The results show that the tetrahedral framework nucleic acids promoted the recovery of post-traumatic cognitive function by enhancing the proliferation of endogenous neural stem cells. Besides, tetrahedral framework nucleic acids modulated the neuroinflammatory response in the acute phase by inhibiting excessive astrocyte and microglial activation. Taken together, the results of the study indicate tetrahedral framework nucleic acids for treatment of cognitive impairment post traumatic brain injury.
- Tetrahedral framework nucleic acids,
- Traumatic brain injury,
- Cognitive impairment,
- Neural stem cell,
- Neuroinflammation
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