Citation: Xinru You, Liying Wang, Junfu Zhang, Tong Tong, Chunlei Dai, Chun Chen, Jun Wu. Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy[J]. Chinese Chemical Letters, ;2023, 34(4): 107720. doi: 10.1016/j.cclet.2022.07.063 shu

Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy

Xinru You ^{a, b} ,
Liying Wang ^b ,
Junfu Zhang ^c ,
Tong Tong ^b ,
Chunlei Dai ^b ,
Chun Chen ^{a, *,} ,
Jun Wu ^{a, b, *,}

a.
Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China
b.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518057, China
c.
Department of Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China

chenchun69@126.com

wujun29@mail.sysu.edu.cn

Received Date: 14 May 2022
Revised Date: 23 July 2022
Accepted Date: 27 July 2022
Available Online: 2 August 2022

Figures(7)

The clinical efficacy of chemotherapeutic drugs is hindered by their poor aqueous solubility, low bioavailability and severe side effects. In recent years, polymeric nanocarriers have been used for drug delivery to improve the efficacy of many chemotherapeutics. In this study, a series of biodegradable phenylalanine-based poly(ester amide) (Phe-PEA) with tunable molecular weights (MWs) were synthesized to systematically investigate the relationship between the polymer MW and the efficacy of the corresponding polymeric nanoparticles (NPs). The results indicated that a range of polymers with different MWs can be obtained by varying the monomer ratio or reaction time. Doxorubicin (DOX), a classic clinical lymphoma treatment strategy, was selected as a model drug. The loading capacity and stability of the higher MW polymeric NPs were superior to those of the lower MW ones. Moreover, in vitro and in vivo data revealed that high MW polymeric NPs had better anticancer efficacy against lymphoma and higher biosafety than low MW polymeric nanoparticles and DOX. Therefore, this study suggests the importance of polymer MW for drug delivery systems and provides valuable guidance for the design of enhanced polymeric drug carriers for lymphoma treatment.
- Nanoparticles,
- Drug delivery,
- Lymphoma therapy,
- Polymer molecular weight,
- Poly(ester amide)
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