Citation: Yuan Xu, Liling Huang, Yuyang Bi, Qi Song, Mengmeng Zhang, Lingfeng Zhang, Tianjiao Zhou, Lei Xing, Hulin Jiang. Dual inhibition of glucose uptake and energy supply synergistically restrains the growth and metastasis of breast cancer[J]. Chinese Chemical Letters, ;2023, 34(4): 107719. doi: 10.1016/j.cclet.2022.07.062 shu

Dual inhibition of glucose uptake and energy supply synergistically restrains the growth and metastasis of breast cancer

Yuan Xu ^a ,
Liling Huang ^a ,
Yuyang Bi ^a ,
Qi Song ^a ,
Mengmeng Zhang ^a ,
Lingfeng Zhang ^a ,
Tianjiao Zhou ^{a, *,} ,
Lei Xing ^{a, *,} ,
Hulin Jiang ^{a, b, *,}

a.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
b.
Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China

zhoutj1993@163.com

xinglei6xl@163.com

jianghulin3@163.com

Received Date: 13 April 2022
Revised Date: 23 July 2022
Accepted Date: 27 July 2022
Available Online: 3 August 2022

Figures(5)

Metastatic breast cancer (MBC) is one of the most common and knotty diseases in female population which could place them in a life-threatening condition. For malignant proliferation and migration, cancer cells require a large amount of glucose and energy to meet the demand of rapid metabolism. Hence, efficiently diminishing the utilization of energy substances by cancer cells is emerging as validated therapeutic strategies for cancer therapy. Herein, a nanoplatform with dual-inhibition of glucose uptake and oxidative phosphorylation (OXPHOS) was designed, which consisted of albendazole (ABZ) and atovaquone (ATO) by simple carrier-free self-assembling. The introduction of ABZ could evidently decrease glucose uptake to reduce the main "energy fuel" of cancer cells. Meanwhile, as a blocker of OXPHOS, ATO would reduce adenosine triphosphate (ATP) production and ameliorate hypoxia microenvironment by suppressing mitochondrial respiratory chain. Under such dual inhibition of energy metabolism, AA NPs exerted synergistic energy exhaustion effect and outstanding hypoxia improvement function, efficiently inhibiting tumor growth and metastasis. This research not only illustrates the feasibility of energy metabolism therapy by co-inhibiting glucose uptake and OXPHOS, but also provides an ingenious tactic to diminish metastasis during MBC treatment
- Metastatic breast cancer,
- Self-assembled nanosystem,
- Energy exhaustion,
- Hypoxia alleviation,
- Synergistic therapy
1. [1]
  H.M. Fang, X.F. Zhao, X.L. Zhao, et al., Biomacromolecules 21 (2020) 104–113. doi: 10.1021/acs.biomac.9b01012
2. [2]
  E.B. Rankin, A.J. Giaccia, Science 352 (2016) 175–180. doi: 10.1126/science.aaf4405
3. [3]
  X.Q. Zhang, Y.M. Huang, H.L. Song, et al., J. Control. Release 328 (2020) 454–469. doi: 10.1016/j.jconrel.2020.08.066
4. [4]
  T.J. Zhou, L. Xing, Y.T. Fan, et al., J. Control. Release 309 (2019) 82–93. doi: 10.1016/j.jconrel.2019.07.028
5. [5]
  E.S. McDonald, A.S. Clark, J. Tchou, et al., J. Nucl. Med. 57 (2016) 9S–16S. doi: 10.2967/jnumed.115.157834
6. [6]
  X. Wang, J. Veeraraghavan, C.C. Liu, et al., Clin. Cancer Res. 27 (2021) 2648–2662. doi: 10.1158/1078-0432.CCR-20-2961
7. [7]
  S.B. Diego, P.G. José L, P.S. Mariano, et al., Cancer Discov. 11 (2021) 1353–1367. doi: 10.1158/2159-8290.CD-20-1312
8. [8]
  X.Y. Chen, B.W. Li, X.H. Chen, et al., Chin. Chem. Lett. 31 (2020) 1153–1158. doi: 10.1016/j.cclet.2019.06.022
9. [9]
  Y. Tian, W.L. Jiang, W.X. Wang, et al., Biomaterials 271 (2021) 120736. doi: 10.1016/j.biomaterials.2021.120736
10. [10]
  F. Tian, S.Y. Wang, K. Shi, et al., Adv. Sci. 8 (2021) e2102595. doi: 10.1002/advs.202102595
11. [11]
  R.H. Jin, Z.N. Liu, T. Liu, et al., Chin. Chem. Lett. 32 (2021) 3076–3082. doi: 10.1016/j.cclet.2021.03.084
12. [12]
  M.G. Vander Heiden, L.C. Cantley, C.B. Thompson, et al., Science 324 (2009) 1029–1033. doi: 10.1126/science.1160809
13. [13]
  Y.Y. Deng, P.Y. Song, X.H. Chen, et al., ACS Nano 14 (2020) 9711–9727. doi: 10.1021/acsnano.0c01350
14. [14]
  Y.X. Guo, H.R. Jia, X.D. Zhang, et al., Small 16 (2020) e2000897. doi: 10.1002/smll.202000897
15. [15]
  G.J. Leclerc, J.F. Du, J. DeSalvo, et al., Blood 21 (2012) 2439.
16. [16]
  I. Martinez-Reyes, N.S. Chandel, Cell Metab. 26 (2017) 803–804. doi: 10.1016/j.cmet.2017.11.005
17. [17]
  S. Sivanand, M.G. Vander Heiden, Cancer Cell 37 (2020) 147–156. doi: 10.1016/j.ccell.2019.12.011
18. [18]
  S. Tohyama, J. Fujita, T. Hishiki, et al., Cell Metab. 23 (2016) 663–674. doi: 10.1016/j.cmet.2016.03.001
19. [19]
  J.S. Brunner, L.W.S. Finley, Mol. Cell 81 (2021) 3738–3878e1.
20. [20]
  L.P. Zuo, W.D. Nie, S.M. Yu, et al., Angew. Chem. Int. Ed. 60 (2021) 25365–25371. doi: 10.1002/anie.202109258
21. [21]
  T.J. Zhou, L. Xing, Y.T. Fan, et al., J. Control. Release 307 (2019) 44–54. doi: 10.1016/j.jconrel.2019.06.016
22. [22]
  M.C. Vinaud, C.S. Ferreira, S.L. Junior Rde, et al., Exp. Parasitol. 120 (2008) 221–226. doi: 10.1016/j.exppara.2008.07.008
23. [23]
  H.Q. Zhu, B. Zhang, N.L. Zhu, et al., Chin. Chem. Lett. 32 (2021) 1220–1223. doi: 10.1016/j.cclet.2020.09.003
24. [24]
  L.P. Zhao, R.R. Zheng, H.Q. Chen, et al., Nano Lett. 20 (2020) 2062–2071. doi: 10.1021/acs.nanolett.0c00047
25. [25]
  H.Y. Kim, R. Li, T.S.C. Ng, et al., ACS Nano 12 (2018) 12015–12029. doi: 10.1021/acsnano.8b04338
26. [26]
  D.R.B. Nora Graf, N. Kolishetti, C. Muus, et al., ACS Nano 5 (2012) 4530–4539.
27. [27]
  L. Liang, Y. Peng, L. Qiu, et al., J. Control. Release 337 (2021) 117–131. doi: 10.1016/j.jconrel.2021.07.023
28. [28]
  Y.T. Fan, T.J. Zhou, P.F. Cui, et al., Adv. Funct. Mater. 29 (2019) 1806708. doi: 10.1002/adfm.201806708
29. [29]
  L. Xing, C.X. Yang, D. Zhao, et al., J. Control. Release 331 (2021) 460–471. doi: 10.1016/j.jconrel.2021.01.037
30. [30]
  C. Wang, W.R. Liu, S. Tan, et al., Mol. Cancer 21 (2022) 63. doi: 10.1186/s12943-022-01546-4
31. [31]
  M. Elgendy, M. Ciro, A. Hosseini, et al., Cancer Cell 35 (2019) 798–815. doi: 10.1016/j.ccell.2019.03.007
32. [32]
  Y. Wang, L.F. Hu, P.F. Cui, et al., Adv. Mater. 33 (2021) 2103307. doi: 10.1002/adma.202103307
33. [33]
  R. Martínez-Espinosa, R. Argüello-García, E. Saavedra, et al., Front. Microbiol. 6 (2015) 800.
34. [34]
  M. Skwarski, D.R. McGowan, E. Belche, et al., Clin. Cancer Res. 27 (2021) 2459–2469. doi: 10.1158/1078-0432.CCR-20-4128
35. [35]
  H. Singh, D. Sareen, J.M. George, et al., Coordin. Chem. Rev. 452 (2022) 214283. doi: 10.1016/j.ccr.2021.214283
36. [36]
  T.J. Zhou, Y. Xu, L. Xing, et al., Adv. Mater. 33 (2021) e2100114. doi: 10.1002/adma.202100114
37. [37]
  F. Zhou, J. Du, J.J. Wang, et al., Mol. Cell Biochem. 428 (2017) 171–178. doi: 10.1007/s11010-016-2927-3
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