Citation: Jinlin Zhou, Kun Li, Lei Shi, Hong Zhang, Haoyuan Wang, Yimin Shan, Shanyong Chen, Xiao-Qi Yu. Hydrogen-bond locked purine chromophores with high photostability for lipid droplets imaging in cells and tissues[J]. Chinese Chemical Letters, ;2023, 34(4): 107689. doi: 10.1016/j.cclet.2022.07.032 shu

Hydrogen-bond locked purine chromophores with high photostability for lipid droplets imaging in cells and tissues

Jinlin Zhou ^a ,
Kun Li ^a ,
Lei Shi ^b ,
Hong Zhang ^a ,
Haoyuan Wang ^a ,
Yimin Shan ^a ,
Shanyong Chen ^{a, *,} ,
Xiao-Qi Yu ^{a, c, *,}

a.
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
b.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610064, China
c.
Department of Chemistry, Xihua University, Chengdu 610039, China

chensy@scu.edu.cn

xqyu@scu.edu.cn

Received Date: 8 May 2022
Revised Date: 11 July 2022
Accepted Date: 15 July 2022
Available Online: 28 July 2022

Figures(5)

Recently, hydrogen-bonding has attracted extensive attention in the design of chromophores. Here, a new class of hydrogen-bond locked purine chromophores (HOPs) were reported by introducing a hydroxyphenyl group into the C(6) position of purine. The intramolecular hydrogen bond plays a dominant role to light up these probes. As a bonus, HOPs show high photostability. Moreover, HOPs exhibit remarkable capability for the specific lipid droplets imaging in living cells with excellent biocompatibility and are also potential for diagnosing fatty liver diseases. These results bring important new insights into the photophysics of the purine-based chromophores and provide a new scaffold with high photostability for bioimaging.
- Fluorescent probe,
- Purine,
- Hydrogen bond,
- Lipid droplets,
- Fatty liver
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