Citation: Haibo Wang, Xuexin Bai, Yahui Huang, Yueru Chen, Guoqiang Dong, Tianmiao Ou, Shanchao Wu, Defeng Xu, Chunquan Sheng. Discovery of novel triple targeting G-quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine[J]. Chinese Chemical Letters, ;2023, 34(4): 107671. doi: 10.1016/j.cclet.2022.07.014 shu

Discovery of novel triple targeting G-quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine

Haibo Wang ^{a, b, 1} ,
Xuexin Bai ^{b, 1} ,
Yahui Huang ^b ,
Yueru Chen ^c ,
Guoqiang Dong ^b ,
Tianmiao Ou ^c ,
Shanchao Wu ^{b, *,} ,
Defeng Xu ^{a, *,} ,
Chunquan Sheng ^{b, *,}

a.
National & Local Joint Engineering Research Center for High-efficiency Refining and High-quality Utilization of Biomass, School of Pharmacy, Changzhou University, Changzhou 213164, China
b.
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
c.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

wushanchao07_2@126.com

markxu@cczu.edu.cn

shengcq@smmu.edu.cn

Received Date: 4 April 2022
Revised Date: 7 July 2022
Accepted Date: 8 July 2022
Available Online: 9 July 2022

Figures(7)

Inspired by the indolopyridoquinazoline scaffold of natural products evodiamine and rutaecarpine, novel triple G4 and Top1/2 ligands were rationally designed and synthesized. Systematic structure–activity relationship (SAR) studies led to the discovery of compound 15g, which effectively induced and stabilized G4 and inhibited Top1/2 with potent antitumor activity. Compound 15g represents a valuable chemical tool or lead compound for antitumor drug discovery. This proof-of-concept study also validated the feasibility of using planar natural products scaffold as templates to design new G4 ligands.
- Indolopyridoquinazoline,
- G-quadruplex,
- Topoisomerase,
- Structure-activity relationship,
- Antitumor activity
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