Citation: Minghao Ren, Chengyong Zhou, Linfang Wang, Xin Lv, Wei Guo. Rationally designed meso-benzimidazole-pyronin with emission wavelength beyond 700 nm enabling in vivo visualization of acute-liver-injury-induced peroxynitrite[J]. Chinese Chemical Letters, ;2023, 34(4): 107646. doi: 10.1016/j.cclet.2022.06.069 shu

Rationally designed meso-benzimidazole-pyronin with emission wavelength beyond 700 nm enabling in vivo visualization of acute-liver-injury-induced peroxynitrite

Minghao Ren ^a ,
Chengyong Zhou ^a ,
Linfang Wang ^{a, *,} ,
Xin Lv ^{b, *,} ,
Wei Guo ^b

a.
Department of Chemistry, Changzhi University, Changzhi 046011, China
b.
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

wanglf1023@163.com

lvxin@sxu.edu.cn

Received Date: 29 March 2022
Revised Date: 24 June 2022
Accepted Date: 27 June 2022
Available Online: 30 June 2022

Figures(9)

Fluorescent dyes with fluorescence emission above 700 nm are favorable for bio-imaging due to the higher tissue transparency and lower background fluorescence. In this study, we present a meso-benzimidazole-pyronin platform (SiBMs) with fluorescence emission maxima above 700 nm, which possess good cell permeability, photostability, and lysosomal localization. The great photophysical properties of the SiBMs encouraged us to further exploit their application toward bio-imaging. We synthesized the reduced 'dihydro' derivative HSiBM3 for sensing ONOO⁻, with high selectivity and sensitivity and a fast fluorescence "off-on" response (within 2 s). Then, we confirmed the potential of HSiBM3 for visualizing exogenous and endogenous ONOO⁻ in cells and mice. More importantly, HSiBM3 was successfully employed for visualizing acute-liver-injury-induced peroxynitrite.
- Near infrared fluorescent dyes,
- Lysosome-targetable,
- Fluorescence probe,
- Peroxynitrite,
- Acute liver injury
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