Citation: Xiaoyu Guo, Jinhuan Dong, Yunjie Zhu, Lan Bao, Zhongyan Hu, Xianxiu Xu. Copper-catalyzed chemoselective heterocyclization of two isocyanides: Facile access to pyrroloazepinone derivatives[J]. Chinese Chemical Letters, ;2023, 34(2): 107608. doi: 10.1016/j.cclet.2022.06.031 shu

Copper-catalyzed chemoselective heterocyclization of two isocyanides: Facile access to pyrroloazepinone derivatives

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science, Shandong Normal University, Ji'nan 250014, China

huzy@sdnu.edu.cn

xuxx677@sdnu.edu.cn

Received Date: 17 March 2022
Revised Date: 8 June 2022
Accepted Date: 12 June 2022
Available Online: 17 June 2022

Figures(6)

A Cu-catalyzed chemoselective heterocyclization of o-cinnamoyl arylisocyanides with α-substituted tosylmethyl isocyanides is developed for the efficient synthesis benzopyrroloazepinones. An isocyanide insertion into the C–Cu bond of organocuprate intermediate is involved for the formation of the seven-membered azepinone ring.
- Isocyanides,
- Domino reactions,
- Pyrroloazepinones
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