Citation: Jiali Deng, Rui Wang, Shu Huang, Jinsong Ding, Wenhu Zhou. Macrophages-regulating nanomedicines for sepsis therapy[J]. Chinese Chemical Letters, ;2023, 34(3): 107588. doi: 10.1016/j.cclet.2022.06.011 shu

Macrophages-regulating nanomedicines for sepsis therapy

Jiali Deng ^{a, 1} ,
Rui Wang ^{a, 1} ,
Shu Huang ^b ,
Jinsong Ding ^{a, *,} ,
Wenhu Zhou ^{a, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Department of Orthopedics, Hunan Provincial People's Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha 410005, China

dingjs0221@163.com

zhouwenhuyaoji@163.com

Received Date: 22 March 2022
Revised Date: 26 May 2022
Accepted Date: 5 June 2022
Available Online: 10 June 2022

Figures(6)

Sepsis is the leading cause of death in intensive care unit (ICU), which is caused by deregulated immune responses to pathogens infection. Clinically, sepsis treatment is limited to antibiotics and supportive care, while there still lacks of specific molecular therapy. As a type of immune dysfunction disease, macrophages have been recognized as the key immune cells precipitating in the whole process of sepsis, which is activated into M1-like to trigger various inflammatory responses at early stage whereas polarized into M2-like to cause immunosuppression in later stage. Therefore, great attention has been paid on the design of nanomedicines to regulate the functions of macrophages for etiological treatment of sepsis, by virtue of the unique advantages of nano-drug delivery systems, such as enhanced drug bioavailability, targetability, reduced side-effects. This critical review aims to summarize the recent progress of macrophages-regulating nanoparticles for sepsis therapy. First, the essential roles of macrophages in the development and progression of sepsis have been introduced, including the positive roles of macrophages to combat infections and dysfunction of macrophages to cause body damages. We then focus our main attention to discuss the nanomedicines with different therapeutic mechanisms corresponding to each stage of sepsis, such as infection blockage, inflammation inhibition, immune functions recovery, as well as multifunctional nanomedicines. Finally, a few limitations of current nanomedicines are highlighted, and future perspective are speculated for potential clinical translation, which might pave the way for the development of macrophages-centered nanomedicines for more effective sepsis therapy.
- Nanomedicine,
- Sepsis,
- Macrophages,
- Infections,
- Inflammation,
- Immunity
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沈阳化工大学材料科学与工程学院沈阳 110142