Citation: Yi Ding, Yu Jiang, Sunjie Xu, Xiujuan Xin, Faliang An. Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum[J]. Chinese Chemical Letters, ;2023, 34(2): 107562. doi: 10.1016/j.cclet.2022.05.076 shu

Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

flan2016@ecust.edu.cn

Received Date: 5 January 2022
Revised Date: 20 May 2022
Accepted Date: 23 May 2022
Available Online: 27 May 2022

Figures(6)

Perpyrrospirone A (1) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold with a unique peroxide-bridged 8, 9-dioxa-2-azaspiro[4.7]dodecane core from marine-derived Penicillium citrinum. Compounds 2 and 3 possessed rare oxatetracyclic (6/5/6/5) skeleton fused with a 13-menbered-ring macrocyclic moiety. Their structure and absolute configurations were determined by comprehensive spectroscopic analyses, ECD data coupled with TD-DFT calculations and X-ray diffraction experiments. In addition, 7 showed cytotoxicity and induced apoptosis of Hela cells in a dose-dependent manner after a 48 h treatment.
- Penicillium citrinum,
- Hirsutellone,
- Peroxide,
- X-ray,
- Cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142