Citation: Yufan Fan, Fangyuan Wang, Fanbin Hou, Lai Wei, Guanghao Zhu, Dongfang Zhao, Qing Hu, Tao Lei, Ling Yang, Ping Wang, Guangbo Ge. A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples[J]. Chinese Chemical Letters, ;2023, 34(2): 107557. doi: 10.1016/j.cclet.2022.05.071 shu

A novel TICT-based near-infrared fluorescent probe for light-up sensing and imaging of human serum albumin in real samples

Yufan Fan ^{a, 1} ,
Fangyuan Wang ^{a, d, 1} ,
Fanbin Hou ^a ,
Lai Wei ^b ,
Guanghao Zhu ^a ,
Dongfang Zhao ^a ,
Qing Hu ^a ,
Tao Lei ^c ,
Ling Yang ^{a, *,} ,
Ping Wang ^{a, *,} ,
Guangbo Ge ^{a, *,}

a.
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
b.
Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
c.
Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
d.
Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201204, China

yling@shutcm.edu.cn

pwang@shutcm.edu.cn

geguangbo@shutcm.edu.cn

Received Date: 11 March 2022
Revised Date: 9 May 2022
Accepted Date: 23 May 2022
Available Online: 27 May 2022

Figures(7)

Human serum albumin (HSA) has emerged as a pivotal biomarker and prognostic indicator for various human diseases. Real-time sensing and visual tracking of HSA in plasma or other biological systems will immensely facilitate the basic researchers and clinicians to better understand HSA-associated biological processes. Herein, a novel near-infrared (NIR) fluorescent probe (7-HTCF) was rationally constructed for light-up sensing and in-situ imaging of HSA in real samples, based on the principle of twisted intramolecular charge transfer (TICT). Under physiological conditions, 7-HTCF could be efficiently trapped by HSA to form a stable complex via binding on a non-drug binding site, while the complex emitted strong fluoresce signals around 670 nm. Further investigations demonstrated that 7-HTCF displayed a great combination of excellent selectivity and good chemical stability, as well as rapid fluorescent response and ultra-high sensitivity for HSA detection. Particularly, the newly developed light-up probe has been successfully utilized for quantitative detection of HSA in diluted plasma samples, while its readouts are hardly affected by the addition of therapeutic agents and herbal medicines. 7-HTCF is also successfully used for in-situ imaging of the reabsorbed HSA in living renal cells, while this dye exhibits good cell permeability and high resolution for in-situ imaging in living cells. Collectively, a novel TICT-based near-infrared fluorescent probe was devised for highly selective and ultra-sensitive sensing of HSA in plasma samples or imaging HSA in living cells, which offered a practical tool for clinical tests and for exploring HSA-associated biological processes.
- Human serum albumin,
- Near-infrared probe,
- High-throughput detection,
- Confocal imaging
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