Citation: Ning Guo, Yu Xia, Yuxi Duan, Quanxin Wu, Le Xiao, Yaxin Shi, Bin Yang, Yun Liu. Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy[J]. Chinese Chemical Letters, ;2023, 34(2): 107542. doi: 10.1016/j.cclet.2022.05.056 shu

Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy

Ning Guo ^a ,
Yu Xia ^a ,
Yuxi Duan ^a ,
Quanxin Wu ^a ,
Le Xiao ^a ,
Yaxin Shi ^a ,
Bin Yang ^{b, *,} ,
Yun Liu ^{a, c, *,}

a.
Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China
b.
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
c.
The Marine Biomedical Research Institute of Guangdong, Zhanjiang 524023, China

bin.yang@gzhmu.edu.cn

liuyun_2017@hotmail.com

Received Date: 27 January 2022
Revised Date: 13 May 2022
Accepted Date: 17 May 2022
Available Online: 21 May 2022

Figures(5)

Cu_2-xS nanostructures have been intensively studied as outstanding chemodynamic therapy (CDT) and good photothermal therapy (PTT) antibacterial agents due to their highly efficient Cu(Ⅰ)-initiated Fenton-like catalytic activity and good photothermal conversion property. However, they still suffer from shortage of Cu(Ⅰ) supply in the long-term and comparatively low inherent photothermal conversion efficiency. Herein, we constructed a self-enhanced synergistic PTT/CDT nanoplatform (Cu_1.94S@MPN) by coating Cu_1.94S nanoparticles with Fe(Ⅲ)/tannic acid based metal-polyphenol networks (MPN). Activated by the acidic bacterial infection microenvironment, Cu_1.94S@MPN could be decomposed to continuously release Cu(Ⅱ), Fe(Ⅲ) ions and tannic acid. As the result of tannic acid-involved Cu and Fe redox cycling, Cu(Ⅰ)/Fe(Ⅱ)-rich CDT could be achieved through the highly accelerated catalytic Fenton/Fenton-like reactions. More importantly, experimental results demonstrated that Cu_1.94S@MPN exhibited both excellent photothermal antibacterial and photothermal-enhanced CDT properties to eradicate bacteria in vitro and in vivo. Overall, this novel nanotherapeutics has great potential to become a clinic candidate for anti-infective therapy in future.
- Antibacterial,
- Self-enhanced,
- Photothermal therapy,
- Chemodynamic therapy,
- Anti-infective therapy
1. [1]
  T.M. Rawson, R.C. Wilson, A. Holmes, Clin. Microbiol. Infect. 27 (2021) 9–11. doi: 10.1016/j.cmi.2020.09.025
2. [2]
  C. Liu, Y. Wen, W. Wan, J. Lei, X. Jiang, Int. Immunopharmacol. 90 (2021) 107157. doi: 10.1016/j.intimp.2020.107157
3. [3]
  S. Yu, G. Li, R. Liu, D. Ma, W. Xue, Adv. Funct. Mater. 28 (2018) 1707440. doi: 10.1002/adfm.201707440
4. [4]
  S. Yu, G. Li, P. Zhao, et al., Adv. Funct. Mater. 29 (2019) 1905697. doi: 10.1002/adfm.201905697
5. [5]
  S. Wu, Y. Huang, J. Yan, et al., Adv. Funct. Mater. 31 (2021) 2103442. doi: 10.1002/adfm.202103442
6. [6]
  E. Bakkeren, M. Diard, W.D. Hardt, Nat. Rev. Microbiol. 18 (2020) 479–490. doi: 10.1038/s41579-020-0378-z
7. [7]
  D.G. Joakim Larsson, C.F. Flach, Nat. Rev. Microbiol. (20) (2022) 257–269.
8. [8]
  L. Jin, X. Liu, C. Bian, et al., Chin. Chem. Lett. 31 (2020) 2137–2141. doi: 10.1016/j.cclet.2019.12.020
9. [9]
  H. Yan, H. Ni, Y. Yang, et al., Chin. Chem. Lett. 31 (2020) 1792–1796. doi: 10.1016/j.cclet.2019.12.022
10. [10]
  T.M. Rawson, R.C. Wilson, D. O'Hare, et al., Nat. Rev. Microbiol. 19 (2021) 747–758. doi: 10.1038/s41579-021-00578-9
11. [11]
  M. Miethke, M. Pieroni, T. Weber, et al., Nat. Rev. Chem. 5 (2021) 726–749. doi: 10.1038/s41570-021-00313-1
12. [12]
  J. O'Neill, Tacking drug-resistant infections globally: Final report and recommendations, Review on Antimicrobial Resistance, Government of the United Kingdom, 2016, pp. 1–84.
13. [13]
  P.P. Kalelkar, M. Riddick, A.J. Garia, Nat. Rev. Mater. 7 (2022) 39–54.
14. [14]
  W. Li, E.S. Thian, M. Wang, Z. Wang, L. Ren, Adv. Sci. 8 (2021) 100368.
15. [15]
  Z. Vanic, M.W. Joraholmen, N. Skalko-Basnet, Adv. Drug Deliv. Rev. 178 (2021) 113855. doi: 10.1016/j.addr.2021.113855
16. [16]
  J.M.V. Makabenta, A. Nabawy, C.H. Li, et al., Nat. Rev. Microbiol. 19 (2021) 23–36. doi: 10.1038/s41579-020-0420-1
17. [17]
  F. Xiao, B. Cao, L. Wen, et al., Chin. Chem. Lett. 31 (2020) 2516–2519. doi: 10.1016/j.cclet.2020.06.038
18. [18]
  Y. Li, W. Xiu, K. Yang, et al., Mater. Horiz. 8 (2021) 1264–1271. doi: 10.1039/D0MH01921F
19. [19]
  D. Li, T. Chen, Y. Zhang, Y. Xu, H. Niu, Adv. Healthcare Mater. 10 (2021) 2100716. doi: 10.1002/adhm.202100716
20. [20]
  M. Song, Y. Cheng, Y. Tian, et al., Adv. Funct. Mater. 30 (2020) 2003587. doi: 10.1002/adfm.202003587
21. [21]
  J. Huo, Q. Jia, H. Huang, et al., Chem. Soc. Rev. 50 (2021) 8762–8789. doi: 10.1039/D1CS00074H
22. [22]
  J.W. Xu, K. Yao, Z.K. Xu, Nanoscale 11 (2019) 8680–8691. doi: 10.1039/C9NR01833F
23. [23]
  C.R. McCollum, J.R. Bertram, P. Nagpal, A. Chatterjee, ACS Appl. Mater. Interfaces 13 (2021) 30404–30419. doi: 10.1021/acsami.1c08306
24. [24]
  T.W. Chang, H. Ko, W.S. Huang, et al., Chem. Eng. J. 428 (2022) 131237. doi: 10.1016/j.cej.2021.131237
25. [25]
  X. Guo, B. Cao, C. Wang, S. Lu, X. Hu, Nanoscale 12 (2020) 7651–7659. doi: 10.1039/D0NR00181C
26. [26]
  C. Cao, N. Yang, Y. Zhao, et al., Nano Today 39 (2021) 101165. doi: 10.1016/j.nantod.2021.101165
27. [27]
  Z. Tang, Y. Liu, M. He, W. Bu, Angew. Chem. Int. Ed. 58 (2019) 946–956. doi: 10.1002/anie.201805664
28. [28]
  C. Wang, W. Zhao, B. Cao, et al., Chem. Mater. 32 (2020) 7725–7738. doi: 10.1021/acs.chemmater.0c02055
29. [29]
  G. Guo, H. Zhang, H. Shen, et al., ACS Nano 14 (2020) 13391–13405. doi: 10.1021/acsnano.0c05255
30. [30]
  Q. Xu, Y. Hua, Y. Zhang, et al., Adv. Healthcare Mater. 10 (2021) 2101374. doi: 10.1002/adhm.202101374
31. [31]
  N. Yang, H. Guo, C. Cao, et al., Biomaterials 275 (2021) 120918. doi: 10.1016/j.biomaterials.2021.120918
32. [32]
  X. Zhu, X. Chen, Z. Jia, et al., J. Colloid Interface Sci. 603 (2021) 615–632. doi: 10.1016/j.jcis.2021.06.073
33. [33]
  Y. Shi, J. Yin, Q. Peng, et al., Biomater. Sci. 8 (2020) 6093–6099. doi: 10.1039/D0BM01165G
34. [34]
  X. Lin, Y. Fang, Z. Hao, et al., Small 17 (2021) 2103303. doi: 10.1002/smll.202103303
35. [35]
  E.A.D.R. Hans, M.D. Regulacio, Chem. Eur. J. 27 (2021) 11030–11040. doi: 10.1002/chem.202101392
36. [36]
  A. Nain, S.C. Wei, Y.F. Lin, et al., ACS Appl. Mater. Interfaces 13 (2021) 7865–7878. doi: 10.1021/acsami.0c18999
37. [37]
  Y. Zhou, Z. Chen, S. Zeng, et al., ACS Appl. Mater. Interfaces 13 (2021) 53659–53670. doi: 10.1021/acsami.1c17985
38. [38]
  C. Dong, W. Feng, W. Xu, et al., Adv. Sci. 7 (2020) 2001549. doi: 10.1002/advs.202001549
39. [39]
  X. Yu, T. Shang, G. Zheng, et al., Chin. Chem. Lett. 33 (2022) 1895–1900. doi: 10.1016/j.cclet.2021.10.021
40. [40]
  Y. Yu, P. Li, C. Zhu, et al., Adv. Funct. Mater. 29 (2019) 1904402. doi: 10.1002/adfm.201904402
41. [41]
  Z. Ren, S. Sun, R. Sun, et al., Adv. Mater. 32 (2020) 1906024. doi: 10.1002/adma.201906024
42. [42]
  Z. Guo, W. Xie, J. Lu, et al., J. Mater. Chem. B 9 (2021) 4098–4110. doi: 10.1039/D1TB00383F
43. [43]
  T. Liu, M. Zhang, W. Liu, et al., ACS Nano 12 (2018) 3917–3927. doi: 10.1021/acsnano.8b01456
44. [44]
  R. Shen, W. Chen, Q. Peng, et al., Chem 5 (2019) 2099–2110. doi: 10.1016/j.chempr.2019.04.024
45. [45]
  X. Deng, K. Li, X. Cai, et al., Adv. Mater. 29 (2017) 1701266. doi: 10.1002/adma.201701266
1. [1]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
2. [2]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
3. [3]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
4. [4]
  Wenjuan Jin , Zelong Chen , Yi Wang , Jiaxuan Li , Jiahui Li , Yuxin Pei , Zhichao Pei . Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy. Chinese Chemical Letters, 2024, 35(7): 109328-. doi: 10.1016/j.cclet.2023.109328
5. [5]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
6. [6]
  Yongkang Yue , Zhou Xu , Kaiqing Ma , Fangjun Huo , Xuemei Qin , Kuanshou Zhang , Caixia Yin . HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials. Chinese Chemical Letters, 2024, 35(8): 109223-. doi: 10.1016/j.cclet.2023.109223
7. [7]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295
8. [8]
  Songtao Cai , Liuying Wu , Yuan Li , Soham Samanta , Jinying Wang , Bing Liu , Feihu Wu , Kaitao Lai , Yingchao Liu , Junle Qu , Zhigang Yang . Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye. Chinese Chemical Letters, 2024, 35(4): 108599-. doi: 10.1016/j.cclet.2023.108599
9. [9]
  Feng Cui , Fangman Chen , Xiaochun Xie , Chenyang Guo , Kai Xiao , Ziping Wu , Yinglu Chen , Junna Lu , Feixia Ruan , Chuanxu Cheng , Chao Yang , Dan Shao . Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation. Chinese Chemical Letters, 2024, 35(4): 108681-. doi: 10.1016/j.cclet.2023.108681
10. [10]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
11. [11]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
12. [12]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
13. [13]
  Tianze Wang , Junyi Ren , Dongxiang Zhang , Huan Wang , Jianjun Du , Xin-Dong Jiang , Guiling Wang . Development of functional dye with redshifted absorption based on Knoevenagel condensation at 1-site in phenyl[b]-fused BODIPY. Chinese Chemical Letters, 2024, 35(6): 108862-. doi: 10.1016/j.cclet.2023.108862
14. [14]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
15. [15]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
16. [16]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
17. [17]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
18. [18]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
19. [19]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
20. [20]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(427)
HTML views(45)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142