Citation: Lei Xu, Shiyu Li, Qi Zhang, Ning Deng, Biao Zhang, Huajian Xu. Hydroarylation of terminal alkynes with arylboronic acids catalyzed by low loadings of palladium[J]. Chinese Chemical Letters, ;2023, 34(2): 107534. doi: 10.1016/j.cclet.2022.05.048 shu

Hydroarylation of terminal alkynes with arylboronic acids catalyzed by low loadings of palladium

School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Institute of Industry & Equipment Technology, Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, Hefei University of Technology, Hefei 230009, China

ndeng@hfut.edu.cn

hjxu@hfut.edu.cn

Received Date: 26 January 2022
Revised Date: 10 May 2022
Accepted Date: 15 May 2022
Available Online: 19 May 2022

Figures(6)

The hydroarylation reaction of terminal alkynes with arylboronic acids catalyzed by low (400 ppm) loadings of palladium has been developed. The reaction is broad in scope and high-yielding, even on multi-gram scale. It is suitable for the synthesis of alkenes labeled with deuterium, and for the late-stage modification of bioactive molecules.
- Hydroarylation,
- Low loadings,
- Terminal alkyne,
- Deuterium-labeled,
- Palladium
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