Citation: Chang Xu, Yue Kang, Xufeng Dong, Daqing Jiang, Min Qi. Integration exosomes with MOF-modified multifunctional scaffold for accelerating vascularized bone regeneration[J]. Chinese Chemical Letters, ;2023, 34(2): 107528. doi: 10.1016/j.cclet.2022.05.042 shu

Integration exosomes with MOF-modified multifunctional scaffold for accelerating vascularized bone regeneration

Chang Xu ^a ,
Yue Kang ^b ,
Xufeng Dong ^{a, *,} ,
Daqing Jiang ^b ,
Min Qi ^{a, *,}

a.
School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, China
b.
Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang 110042, China

dongxf@dlut.edu.cn

minqi@dlut.edu.cn

Received Date: 28 February 2022
Revised Date: 11 May 2022
Accepted Date: 11 May 2022
Available Online: 16 May 2022

Figures(4)

Designing a multifunctional scaffold with osteogenic and angiogenic properties holds promise for ideal bone regeneration. Innovative scaffold was here constructed by immobilizing exosomes derived from human bone mesenchymal stem cells (hBMSCs) onto porous polymer meshes which developed by PLGA and Cu-based MOF (PLGA/CuBDC@Exo). The synthesized exosome-laden scaffold capable of providing a dual cooperative controllable release of bioactive copper ions and exosomes that promote osteogenesis and angiogenesis, thereby achieving cell-free bone regeneration. In vitro assay revealed the composite stent not only substantially upregulated the expression of osteogenic-related proteins (ALP, Runx2, Ocn) and VEGF in hBMSCs, but promoted the migration and tube formation of the human umbilical vein endothelial cells (HUVECs). In vivo evaluation further confirmed this scaffold dramatically stimulated bone regeneration and angiogenesis in critical-sized defects in rats. Altogether, this composite scaffold carrying therapeutic exosomes had an osteogenic-angiogenic coupling effect and offered a new idea for cell-free bone tissue engineering.
- Exosomes,
- Osteogenesis,
- Angiogenesis,
- Metal-organic framework,
- Bone regeneration
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