Citation: Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou, Huile Gao. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment[J]. Chinese Chemical Letters, ;2023, 34(2): 107518. doi: 10.1016/j.cclet.2022.05.032 shu

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Rui Liu ^{a, 1} ,
Cong Luo ^{b, 1} ,
Zhiqing Pang ^{c, 1} ,
Jinming Zhang ^{d, 1} ,
Shaobo Ruan ^{e, 1} ,
Meiying Wu ^{f, 1} ,
Lei Wang ^{g, 1} ,
Tao Sun ^{c, 1} ,
Nan Li ^{h, 1} ,
Liang Han ^{i, 1} ,
Jinjin Shi ^{g, 1} ,
Yuanyu Huang ^{j, 1} ,
Weisheng Guo ^{k, 1} ,
Shaojun Peng ^{l, 1} ,
Wenhu Zhou ^{m, 1} ,
Huile Gao ^{a, *,}

a.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
b.
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
c.
Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 200433, China
d.
State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China
e.
Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China
f.
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
g.
School of Pharmaceutical Sciences, Zhengzhou University, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China
h.
Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
i.
Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
j.
Advanced Research Institute of Multidisciplinary Science, School of Life Science, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China
k.
Radiology Center, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
l.
Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University), Zhuhai 519000, China
m.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China

gaohuile@scu.edu.cn

Received Date: 19 January 2022
Revised Date: 6 May 2022
Accepted Date: 10 May 2022
Available Online: 14 May 2022

Figures(11)

Decades have passed since the first nanoparticles-base medicine was approved for human cancer treatment, and the research and development of nanoparticles for drug delivery are always undergoing. Nowadays, the significant advances complicate nanoparticles' branches, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines and nano-antibodies, etc. These nanoparticles show numerous capabilities in treatment and diagnosis of stubborn diseases like cancer and neurodegenerative diseases, emerging as novel drug carriers or therapeutic agents in future. In this review, the complicated branches of nanoparticles are classified and summarized, with their property and functions concluded. Besides, there are also some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review. Except these excellent works in newly-produced drug delivery nanoparticles, some points of view and future expectations are made in the end.
- Nanoparticles,
- Drug delivery,
- Nanomaterials,
- Delivery strategies,
- Specific delivery,
- Disease diagnosis,
- Disease treatment
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沈阳化工大学材料科学与工程学院沈阳 110142