Citation: Na Li, Qian Zhou, Kun Li, Ting Jiang, Xiao-Qi Yu. Qualitative and quantitative detection of aldehydes in DNA with 2-amino benzamidoxime derivative[J]. Chinese Chemical Letters, ;2023, 34(1): 107471. doi: 10.1016/j.cclet.2022.04.069 shu

Qualitative and quantitative detection of aldehydes in DNA with 2-amino benzamidoxime derivative

Na Li ^{a, 1} ,
Qian Zhou ^{b, 1} ,
Kun Li ^{a, *,} ,
Ting Jiang ^a ,
Xiao-Qi Yu ^{a, b, *,}

a.
Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, China
b.
Department of Chemistry, Xihua University, Chengdu 610039, China

kli@scu.edu.cn

xqyu@scu.edu.cn

Received Date: 11 March 2022
Revised Date: 20 April 2022
Accepted Date: 24 April 2022
Available Online: 28 April 2022

Figures(4)

An aldehyde-reactive probe based on 2-amino benzamidoxime (ABAO) framework was introduced, which can selectively label aldehydes in DNA through intramolecular ring closure under mild aqueous solutions. We screened ABAO derivatives that can undergo a cyclization with the formylated nucleobases to generate a fluorescence nucleoside, and of these derivatives 5-methoxy-ABAO (PMA) emerged as the optimal choice. PMA can sensitively and selectively react with 5fU, 5fC and AP to form fluorogenic dihydroquinazoline derivatives, which also can quantify DNA damages induced by γ-irradiation. PMA-initiated labeling strategy provides great convenience for qualitative and quantitative detection of aldehydes in DNA.
- Aldehydes in DNA,
- 2-Amino benzamidoxime derivative,
- Intramolecular ring closure,
- Fluorescent adducts,
- Quantitative analysis
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