Citation: George Frimpong Boafo, Yejiao Shi, Qingqing Xiao, Kosheli Thapar Magar, Makhloufi Zoulikha, Xuyang Xing, Chao Teng, Emmanuel Brobbey, Xiaotong Li, Xiaohong Jiang, Xiaochun Wang, Yi Yang, Samuel Kesse, Wei He. Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes[J]. Chinese Chemical Letters, ;2022, 33(10): 4600-4604. doi: 10.1016/j.cclet.2022.04.033 shu

Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes

George Frimpong Boafo ^{a, b, 1} ,
Yejiao Shi ^{c, 1} ,
Qingqing Xiao ^{b, 1} ,
Kosheli Thapar Magar ^b ,
Makhloufi Zoulikha ^b ,
Xuyang Xing ^a ,
Chao Teng ^b ,
Emmanuel Brobbey ^b ,
Xiaotong Li ^b ,
Xiaohong Jiang ^b ,
Xiaochun Wang ^b ,
Yi Yang ^b ,
Samuel Kesse ^c ,
Wei He ^{a, b, *,}

a.
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China
b.
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
c.
Institute of Translation Medicine, Shanghai University, Shanghai 200444, China

weihe@cpu.edu.cn

Received Date: 18 November 2021
Revised Date: 10 April 2022
Accepted Date: 11 April 2022
Available Online: 17 April 2022

Figures(5)

Breast cancer is the most prevalent cancer in women, and it was hard to prevent or diagnose at an early stage. Thus, it is imperative to develop advanced therapeutics for effective treatment. Herein, a targeted daunorubicin (DNR) and cytarabine (ara-C) co-delivery system was developed by modifying the ara-C loaded liposomes (LIP-ara-C) with the hyaluronic acid-DNR (HA-DNR) prodrugs. The co-assembled hybrid nanoparticles (HA-DNR/LIP-ara-C HNPs) exhibited good serum and storage stability with an average diameter of approximately 100 nm. By specifically binding to the CD44 receptors that overexpressed on cancer cells, these HNPs could be uptake via endocytosis and accumulate intracellularly, in which an optimized DNR and ara-C combination at a molar ratio of 1:5 could generate enhanced synergistic effects with reduced dose-related toxicity on cancer cells.
- Breast cancer,
- Daunorubicin,
- Cytarabine,
- Co-delivery,
- Liposomes
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沈阳化工大学材料科学与工程学院沈阳 110142