Citation: Xiaogang Peng, Jinling Chang, Ying Gao, Fangfang Duan, Hanli Ruan. Thiocytochalasins A−D, four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1[J]. Chinese Chemical Letters, ;2022, 33(10): 4572-4576. doi: 10.1016/j.cclet.2022.03.063 shu

Thiocytochalasins A−D, four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China

ruanhl@mails.tjmu.edu.cn

Received Date: 28 November 2021
Revised Date: 10 March 2022
Accepted Date: 15 March 2022
Available Online: 17 March 2022

Figures(7)

Four unprecedented sulfur-containing cytochalasans, thiocytochalasins A−D (1−4), were isolated from an endophytic fungus Phoma multirostrata XJ-2-1. Thiocytochalasins A (1) and B (2) feature a novel 5/6/14/5 tetracyclic scaffold, which are the first examples of cytochalasan containing a thiophene moiety. Thiocytochalasins C (3) and D (4) are epimeric cytochalasan homodimers formed via a thioether bridge. Their structures with absolute configurations were established by detailed analysis of the HRESIMS, NMR, and X-ray crystallography. The plausible biogenetic pathway of 1−4 was postulated. Compounds 3 and 4 exhibited significant cytotoxicity against CT26 cells with IC₅₀ values of 0.85 and 0.76 µmol/L, respectively.
- Phoma multirostrata XJ-2-1,
- Sulfur-containing cytochalasans,
- Thiocytochalasins A−D,
- Cytotoxicity,
- Cell cycle
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沈阳化工大学材料科学与工程学院沈阳 110142