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Citation: Qinglong Yan, Yu Miao, Xiaomei Wang, Jifei Ma, Juan Diwu, Ying Zhu, Shuao Wang, Chunhai Fan. ssDNA functionalized nanodiamonds for uranium decorporation[J]. Chinese Chemical Letters, ;2022, 33(7): 3570-3572. doi: 10.1016/j.cclet.2022.03.052 shu

ssDNA functionalized nanodiamonds for uranium decorporation

Qinglong Yan ^{a, b, 1} ,
Yu Miao ^{c, 1} ,
Xiaomei Wang ^{c, 1} ,
Jifei Ma ^b ,
Juan Diwu ^{c, *,} ,
Ying Zhu ^{a, b, *,} ,
Shuao Wang ^c ,
Chunhai Fan ^d

a.
Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201210, China
b.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
c.
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
d.
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

diwujuan@suda.edu.cn

zhuying@zjlab.org.cn

¹

Received Date: 9 February 2022
Revised Date: 11 March 2022
Accepted Date: 14 March 2022
Available Online: 16 March 2022

Figures(3)

The hunt for agents that are suitable for actinide decorporation to reduce the whole-body load of actinide in accidental internal exposure is the ever-lasting goal in radiation protection and medical treatment in nuclear emergency. All current decorporation agents can be categorized as two groups, one is the molecular ligands, and the other is the nanoparticles decorated with molecular ligands. Here in this work, functional nanodiamonds (fNDs) with ssDNA (the endogenous biomacromolecule rich in phosphate groups) loaded on the NDs is reported, which poses good uranyl adsorption selectivity, high cellular uptake, fast excretion, and effective decorporation of uranyl from rat renal proximal tubular epithelial cells (NRK-52E). All those results corroborate that fNDs can potentially serve as a brand new family of chelators for actinide decorporation.
- Nanodiamond,
- ssDNA,
- Uranium,
- Decorporation
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