Citation: Yuying Li, Tianqing Liu, Mengchao Cui. Recent development in selective Tau tracers for PET imaging in the brain[J]. Chinese Chemical Letters, ;2022, 33(7): 3339-3348. doi: 10.1016/j.cclet.2022.03.024 shu

Recent development in selective Tau tracers for PET imaging in the brain

Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China

cmc@bnu.edu.cn

Received Date: 19 January 2022
Revised Date: 5 March 2022
Accepted Date: 6 March 2022
Available Online: 8 March 2022

Figures(9)

Abnormal Tau deposition is a crucial pathological hallmark of various neurodegenerative disorders defined as tauopathies, of which Alzheimer's disease is the most prominent one. To date, a large number of chemical entities with different structures have been developed as Tau imaging tracers for the early diagnosis of tauopathies. Several of them with excellent bio-properties are currently being assessed in clinical trials, and more recently, the Tauvid^TM ([¹⁸F]Flortaucipir, also known as [¹⁸F]AV1451 or [¹⁸F]T807) as the first Tau tracer was approved by the U.S. Food and Drug Administration in 2020. This review summarized the latest development of Tau tracers and analyzed their chemical structures, with particular attention to the effects of chemical structures on biological properties. In addition, we also discuss the limitations of current Tau imaging tracers, issues that need attention in the development of new tracers, and possible future directions.
- Tau,
- PET imaging,
- Tauopathies,
- Alzheimer's disease,
- Selectivity
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沈阳化工大学材料科学与工程学院沈阳 110142