Citation: Ying He, Mengjia Liu, Shun Teng, Lukasz Wojtas, Guangxin Gu, Xiaodong Shi. Synthesis and characterization of fluorescence active G₄-quartet and direct evaluation of self-assembly impact on emission[J]. Chinese Chemical Letters, ;2022, 33(9): 4203-4207. doi: 10.1016/j.cclet.2022.03.007 shu

Synthesis and characterization of fluorescence active G₄-quartet and direct evaluation of self-assembly impact on emission

Ying He ^a ,
Mengjia Liu ^a ,
Shun Teng ^a ,
Lukasz Wojtas ^a ,
Guangxin Gu ^{b, *,} ,
Xiaodong Shi ^{a, *,}

a.
Department of Chemistry, University of South Florida, Tampa, FL 33620, United States
b.
Department of Materials Science, Fudan University, Shanghai 200438, China

Guangxingu@fudan.edu.cn

xmshi@usf.edu

Received Date: 22 October 2021
Revised Date: 27 February 2022
Accepted Date: 2 March 2022
Available Online: 5 March 2022

Figures(6)

Fluorescence (FL) active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G₈-quadruplexes. The p-cyano (p-CN) and 8-anthracene (8-An) substituted guanosines were identified to give the strongest fluorescence with the formation of G₈-octamers (G₈) both in solution (NMR) and solid state (X-ray). This well-defined G₈-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission (AIE), which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition.
- Self-assembly,
- H-bonding,
- G₄-quartet,
- Fluorescence,
- Aggregation induced emission
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Synthesis and characterization of fluorescence active G₄-quartet and direct evaluation of self-assembly impact on emission