Citation: Yongchao Chu, Tao Sun, Chen Jiang. Emerging landscapes of nanosystems based on pre-metastatic microenvironment for cancer theranostics[J]. Chinese Chemical Letters, ;2022, 33(9): 4157-4168. doi: 10.1016/j.cclet.2022.02.051 shu

Emerging landscapes of nanosystems based on pre-metastatic microenvironment for cancer theranostics

Key Laboratory of Smart Drug Delivery (Ministry of Education), Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Research Center on Aging and Medicine, Fudan University, Shanghai 201203, China

sunt@fudan.edu.cn

jiangchen@shmu.edu.cn

Received Date: 17 November 2021
Revised Date: 10 February 2022
Accepted Date: 18 February 2022
Available Online: 22 February 2022

Figures(3)

The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant tumor. The pre-metastatic microenvironment, including the primary tumor-derived components, pre-metastatic niche (PMN), circulating tumor cells (CTCs), micro-metastases, and tumor immune microenvironment (TIM), are the crucial factors to initiate metastasis and form macro-metastases. It may be a more promising strategy for directly targeting pre-metastatic microenvironment-interrelated factors and cells before they have the chance to form secondary tumors to prevent metastasis. During recent years, a variety of nanosystems, with specific microstructures and functional properties, have been devised to selectively target pre-metastatic cells components and interrelated molecular, and exhibited strong potential on anti-metastatic therapy by absorbing and neutralizing primary tumor-derived components, preventing establishment of the PMN, eliminating the CTCs, eradicating the micro-metastases and modulating the TIM. In this review, we comprehensively review the emerging nanosystems based on the pre-metastatic microenvironments. Hopefully, this review can cast new lights for early preventing and attenuating metastatic progression.
- Circulating tumor cells,
- Pre-metastatic niche,
- Cancer metastasis,
- Tumor immune microenvironment,
- Micro-metastasis
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沈阳化工大学材料科学与工程学院沈阳 110142