Citation: Xiaojun Yu, Haitao Ma, Guiying Xu, Zhuang Liu. Radiotherapy assisted with biomaterials to trigger antitumor immunity[J]. Chinese Chemical Letters, ;2022, 33(9): 4169-4174. doi: 10.1016/j.cclet.2022.02.049 shu

Radiotherapy assisted with biomaterials to trigger antitumor immunity

Xiaojun Yu ^a ,
Haitao Ma ^{a, *,} ,
Guiying Xu ^b ,
Zhuang Liu ^{c, *,}

a.
Department of Thoracic Surgery, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215021, China
b.
Department of Cardiothoracic Surgery, Children, s Hospital of Soochow University, Suzhou 215021, China
c.
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China

mht7403@163.com

zliu@suda.edu.cn

Received Date: 1 September 2021
Revised Date: 16 February 2022
Accepted Date: 18 February 2022
Available Online: 22 February 2022

Figures(5)

As an extensively applied therapeutic approach to combat tumors, radiotherapy generates localized ionizing radiation to destruct tumor cells. Despite its importance in clinical oncology, radiotherapy would often cause significant organ toxicity, and its therapeutic effect is limited by tumor hypoxia. Moreover, although abscopal therapeutic effects have occasionally been observed, radiotherapy is still mostly employed as a local treatment method that could hardly control tumor metastases. In recent years, strategies involving biomaterials and nanomedicine have received increasingly high attention to enhance cancer radiotherapy. Beyond sensitizing tumors for radiotherapy via various mechanisms, many biomaterial systems with immune stimulating effects have also been introduced to boost the antitumor immunity post cancer radiotherapy. In this mini-review, we will summarize the progress of different biomaterials and nanomedicine systems in combination with radiotherapy to trigger antitumor immune responses and enhance the efficacy of immunotherapy, and discusses the perspectives and challenges of this research direction aimed at clinical translations.
- Biomaterials,
- Radiotherapy,
- Immunotherapy
1. [1]
  M.R. Button, J.N. Staffurth, Clin. Oncol. 22(2010) 698-706. doi: 10.1016/j.clon.2010.06.020
2. [2]
  G.S. Song, L. Cheng, Y. Chao, K. Yang, Z. Liu, Adv. Mater. 29(2017) 1700996. doi: 10.1002/adma.201700996
3. [3]
  S.L. Liauw, P.P. Connell, R.R. Weichselbaum, Sci. Transl. Med. 5(2013) 173sr2.
4. [4]
  H.E. Barker, J.T. Paget, A.A. Khan, K.J. Harrington, Nat. Rev. Cancer 15(2015) 409-425. doi: 10.1038/nrc3958
5. [5]
  H. Chen, J. Tian, W. He, Z. Guo, J. Am. Chem. Soc. 137(2015) 1539-1547. doi: 10.1021/ja511420n
6. [6]
  Y. Yoshimoto, Y. Suzuki, K. Mimura, et al., PLoS One 9(2014) e92572. doi: 10.1371/journal.pone.0092572
7. [7]
  S. Demaria, B. Ng, M.L. Devitt, et al., Int. J. Radiat. Oncol. Biol. Phys. 58(2004) 862-870. doi: 10.1016/j.ijrobp.2003.09.012
8. [8]
  R. Nath, L.L. Anderson, G. Luxton, et al., Med. Phys. 22(1995) 209-234. doi: 10.1118/1.597458
9. [9]
  J. Kim, J. Youngmi, Exp. Mol. Med. 49(2017) e359. doi: 10.1038/emm.2017.85
10. [10]
  S.A. Rosenberg, N.P. Restifo, Y. J. C, M. R. A, D. M. E, Nat. Rev. Cancer 8(2008) 299-308. doi: 10.1038/nrc2355
11. [11]
  P Sharma, J.P. Allison, Science 348(2015) 56-61. doi: 10.1126/science.aaa8172
12. [12]
  S.D. Karam, D. Raben, Lancet Oncol. 20(2019) e404-e416. doi: 10.1016/S1470-2045(19)30306-7
13. [13]
  K. Fitzgerald, C.B. Simone, Thorac. Surg. Clin. 30(2020) 221-239. doi: 10.1016/j.thorsurg.2020.01.002
14. [14]
  G. Corrao, G. Marvaso, R. Ferrara, et al., Lung Cancer 142(2020) 70-79. doi: 10.1016/j.lungcan.2020.02.017
15. [15]
  L. Belgioia, I. Desideri, A. Errico, et al., Crit. Rev. Oncol. Hematol. 133(2019) 163-170. doi: 10.1016/j.critrevonc.2018.11.009
16. [16]
  S. Bonvalot, P.L. Rutkowski, J. Thariat, et al., Lancet Oncol. 20(2019) 1148-1159. doi: 10.1016/S1470-2045(19)30326-2
17. [17]
  C. Verry, L. Sancey, S. Dufort, et al., BMJ Open 9(2019) e023591. doi: 10.1136/bmjopen-2018-023591
18. [18]
  X.J. Song, J. Xu, C. Liang, et al., Nano Lett. 18(2018) 6360-6368. doi: 10.1021/acs.nanolett.8b02720
19. [19]
  F. Yang, K. Shi, Y. Hao, et al., Bioact. Mater. 6(2021) 3036-3048. doi: 10.1016/j.bioactmat.2021.03.003
20. [20]
  T.J. Royce, M.M. Qureshi, M.T. Truong, J. Am. Coll. Radiol. 15(2018) 1558-1564. doi: 10.1016/j.jacr.2018.04.032
21. [21]
  P. Finkel, B. Frey, F. Mayer, et al., Oncoimmunology 5(2016) e1101206. doi: 10.1080/2162402X.2015.1101206
22. [22]
  S.J. Dovedi, G.L. Bhalla, S.A. Beers, et al., Cancer Immunol. Res. 4(2016) 621-630. doi: 10.1158/2326-6066.CIR-15-0253
23. [23]
  H.B. Stone, L.J. Peters, L. Milas, J. Natl. Cancer Inst. 63(1979) 1229-1235.
24. [24]
  D. Eriksson, T. Stigbrand, Tumour Biol. 31(2010) 363-372. doi: 10.1007/s13277-010-0042-8
25. [25]
  I. Martins, S.Q. Raza, L. Voisin, et al., Cell Death Dis. 9(2018) 716-734. doi: 10.1038/s41419-018-0747-y
26. [26]
  C. Lhuillier, N. Rudqvist, O. Elemento, et al., Genome Med. 11(2019) 40. doi: 10.1186/s13073-019-0653-7
27. [27]
  M.M. Wattenberg, A. Fahim, M.M. Ahmed, et al., Radiat. Res. 182(2014) 126-138. doi: 10.1667/RR13374.1
28. [28]
  E.B. Golden, L. Apetoh, Semin. Radiat. Oncol. 25(2015) 11-17. doi: 10.1016/j.semradonc.2014.07.005
29. [29]
  W. Kim, S. Lee, D. Seo, et al., Cells 8(2019) 1105. doi: 10.3390/cells8091105
30. [30]
  L. Deng, H. Liang, M. Xu, et al., Immunity 41(2014) 843-852. doi: 10.1016/j.immuni.2014.10.019
31. [31]
  Q. Zhao, Y. Wei, S.J. Pandol, et al., Gastroenterology 154(2018) 1822-1835. e2. doi: 10.1053/j.gastro.2018.01.065
32. [32]
  H. Ishikawa, Z. Ma, G.N. Barber, Nature 461(2009) 788-792. doi: 10.1038/nature08476
33. [33]
  L. Apetoh, F. Ghiringhelli, A. Tesniere, et al., Nat. Med. 13(2007) 1050-1059. doi: 10.1038/nm1622
34. [34]
  M. Obeid, A. Tesniere, F. Ghiringhelli, et al., Nat. Med. 13(2007) 54-61. doi: 10.1038/nm1523
35. [35]
  M.P. Chao, S. Jaiswal, R. Weissman-Tsukamoto, et al., Sci. Transl. Med. 2(2010) 63ra94.
36. [36]
  T.B. Dar, R.M. Henson, S.L. Shiao, Front. Immunol. 9(2018) 3077.
37. [37]
  S.L. Topalian, C.G. Drake, D.M. Pardoll, Cancer Cell 27(2015) 450-461. doi: 10.1016/j.ccell.2015.03.001
38. [38]
  N.A. Lockney, M. Zhang, C.G. Morris, et al., Thorac. Cancer 10(2019) 1605-1611. doi: 10.1111/1759-7714.13122
39. [39]
  C. Twyman-Saint Victor, A.J. Rech, A. Maity, et al., Nature 520(2015) 373-377. doi: 10.1038/nature14292
40. [40]
  M. Piper, A.C. Mueller, S.D. Karam, Mol. Carcinog. 59(2020) 754-765. doi: 10.1002/mc.23205
41. [41]
  A. Biernacka, M. Dobaczewski, N.G. Frangogiannis, Growth Factors 29(2011) 196-202. doi: 10.3109/08977194.2011.595714
42. [42]
  M.A. Brach, H.J. Gruss, T. kaisho, et al., J. Biol. Chem. 268(1993) 8466-8472. doi: 10.1016/S0021-9258(18)52898-2
43. [43]
  F.G. Herrera, J. Bourhis, G. Coukos, CA Cancer J. Clin. 67(2017) 65-85. doi: 10.3322/caac.21358
44. [44]
  M. Mondini, P.L. Loyher, P. Hamon, et al., Cancer Immunol. Res. 7(2019) 376-387. doi: 10.1158/2326-6066.CIR-18-0633
45. [45]
  M. McLaughlin, E.C. Patin, M. Pedersen, et al., Nat. Rev. Cancer 20(2020) 203-217. doi: 10.1038/s41568-020-0246-1
46. [46]
  D.M. Pardoll, Nat. Rev. Cancer 12(2012) 252-264. doi: 10.1038/nrc3239
47. [47]
  Y. Min, K.C. Roche, S. Tian, et al., Nat. Nanotechnol. 12(2017) 877-882. doi: 10.1038/nnano.2017.113
48. [48]
  Q. Chen, J.W. Chen, Z.J. Yang, et al., Adv. Mater. 31(2019) e1802228. doi: 10.1002/adma.201802228
49. [49]
  Z.S. Huang, Y.X. Wang, D. Yao, et al., Nat. Commun. 12(2021) 145. doi: 10.1038/s41467-020-20243-8
50. [50]
  S.Q. Gao, T.Y. Li, Y. Guo, et al., Adv. Mater. 32(2020) e1907568. doi: 10.1002/adma.201907568
51. [51]
  B.S. Hilaris, U.K. Henschke, J.G. Holt, Radiology 91(1968) 1163-1170. doi: 10.1148/91.6.1163
52. [52]
  S.Q. Yu, F. Feng, K. Wang, et al., Eur. J. Med. Res. 18(2013) 56. doi: 10.1186/2047-783X-18-56
53. [53]
  A.V. D'Amico, R. Whittington, S.B. Malkowicz, et al., JAMA 280(1998) 969-974. doi: 10.1001/jama.280.11.969
54. [54]
  X. Bai, Y.Y. Wang, Z.Y. Song, et al., Int. J. Mol. Sci. 21(2020) 2480. doi: 10.3390/ijms21072480
55. [55]
  R. Shukla, N. Chanda, A. Zambre, et al., Proc. Natl. Acad. Sci. U. S. A. 109(2012) 12426-12431. doi: 10.1073/pnas.1121174109
56. [56]
  P. Pei, W. Shen, H. Zhou, et al., Nano Today 38(2021) 101144. doi: 10.1016/j.nantod.2021.101144
57. [57]
  Y. Chao, L.G. Xu, C. Liang, et al., Nat. Biomed. Eng. 2(2018) 611-621. doi: 10.1038/s41551-018-0262-6
58. [58]
  L. Tian, Y. Wang, L. Sun, J. Xu, Z. Liu, Matter 1(2019) 1061-1076. doi: 10.1016/j.matt.2019.07.007
59. [59]
  B. Molon, S. Ugel, F.D. Pozzo, et al., J. Exp. Med. 208(2011) 1949-1962. doi: 10.1084/jem.20101956
60. [60]
  C. Wei, X. Dong, J. Liang, et al., J. Biomed. Nanotech. 15(2019) 100-112. doi: 10.1166/jbn.2019.2669
61. [61]
  F. Yang, K. Shi, Y. P. Jia, et al., Appl. Mater. Today 19(2020) 100608. doi: 10.1016/j.apmt.2020.100608
62. [62]
  L.J. Shen, T.J. Zhou, H.L. Jiang, et al., Chin. Chem. Lett. 31(2020) 1709-1716. doi: 10.1016/j.cclet.2020.02.007
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