Citation: Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Naidi Yang, Gongqiang Li, Qiong Wu, Wei Wang, Lin Li, Changmin Yu. Rational design of nanocarriers for mitochondria-targeted drug delivery[J]. Chinese Chemical Letters, ;2022, 33(9): 4146-4156. doi: 10.1016/j.cclet.2022.02.047 shu

Rational design of nanocarriers for mitochondria-targeted drug delivery

Lihua Huang ^a ,
Zonghao Sun ^a ,
Qian Shen ^a ,
Zhongxi Huang ^a ,
Shuangxi Wang ^a ,
Naidi Yang ^a ,
Gongqiang Li ^a ,
Qiong Wu ^{a, *,} ,
Wei Wang ^{b, *,} ,
Lin Li ^a ,
Changmin Yu ^{a, c, **,}

a.
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 211816, China
b.
Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
c.
State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210023, China

^**

iamqwu@njtech.edu.cn

wangw@zaas.ac.cn

iamcmyu@njtech.edu.cn

Received Date: 20 November 2021
Revised Date: 12 February 2022
Accepted Date: 18 February 2022
Available Online: 22 February 2022

Figures(6)

Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed.
- Mitochondria target,
- Mitochondria diseases,
- Therapeutic drugs,
- Nanocarriers
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沈阳化工大学材料科学与工程学院沈阳 110142