Citation: Ya-Qiong Yan, Hao Wang, Yuliang Zhao. Radiolabeled peptide probe for tumor imaging[J]. Chinese Chemical Letters, ;2022, 33(7): 3361-3370. doi: 10.1016/j.cclet.2022.02.016 shu

Radiolabeled peptide probe for tumor imaging

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China

wanghao@nanoctr.cn

zhaoyl@nanoctr.cn

Received Date: 17 November 2021
Revised Date: 9 February 2022
Accepted Date: 9 February 2022
Available Online: 14 February 2022

Figures(6)

Radionuclide imaging is now the premier imaging method in clinical practice for its high sensitivity and tomographic capability. Current clinically available radio imaging methods mostly use positron-emission tomography (PET) and single-photon emission computed tomography (SPECT) to detect anatomic abnormalities that conventional imaging techniques typically have challenges for visualizing. Contrast agents are indispensable for radionuclide imaging, and the radionuclide is always attached to a suitable vector that achieves targeted delivery. Nowadays, peptides have attracted increasing interest in targeting vectors of contrast agents, mainly due to their high specificity for target receptors at nanomolar concentrations and low toxicity. Radiolabeled peptide probes as kinds of PET/SPECT tracers had become essential tools for clinical radionuclide diagnosis. This review mainly summarizes radiolabeled peptide probes for bioimaging, including fundamental concepts of radiolabeled peptide probe design, some typical peptide analogs radiocontrast agents for PET, SPECT, and the combination imaging.
- Peptide,
- Positron-emission tomography (PET),
- Single-photon emission computed tomography (SPECT),
- Bioimaging
1. [1]
  M.L. James, S.S. Gambhir, Physiol. Rev. 92(2012) 897-965. doi: 10.1152/physrev.00049.2010
2. [2]
  X. Han, K. Xu, O. Taratula, K. Farsad, Nanoscale 11(2019) 799-819. doi: 10.1039/C8NR07769J
3. [3]
  X. Wang, H. He, Y. Wang, et al., Chem. Comm. 52(2016) 9232-9235. doi: 10.1039/C6CC03814J
4. [4]
  T.I. Kostelnik, C. Orvig, Chem. Rev. 119(2019) 902-956. doi: 10.1021/acs.chemrev.8b00294
5. [5]
  X. Chen, J. Song, X. Chen, H. Yang, Chem. Soc. Rev. 48(2019) 3073-3101. doi: 10.1039/C8CS00921J
6. [6]
  H. Lusic, M.W. Grinstaff, Chem. Rev. 113(2013) 1641-1666. doi: 10.1021/cr200358s
7. [7]
  E. Boros, A.B. Packard, Chem. Rev. 119(2019) 870-901. doi: 10.1021/acs.chemrev.8b00281
8. [8]
  S.F. Askari Rizvi, H. Zhang, Eur. J. Med. Chem. 221(2021) 113538. doi: 10.1016/j.ejmech.2021.113538
9. [9]
  H.F. Langer, R. Haubner, B.J. Pichler, M. Gawaz, J. Am. Coll. Cardiol. 52(2008) 1-12. doi: 10.1016/j.jacc.2008.03.036
10. [10]
  J. Pellico, P.J. Gawne, R. T M de Rosales, Chem. Soc. Rev. 50(2021) 3355-3423. doi: 10.1039/D0CS00384K
11. [11]
  B.R. Smith, S.S. Gambhir, Chem. Rev. 117(2017) 901-986. doi: 10.1021/acs.chemrev.6b00073
12. [12]
  S. Lee, J. Xie, X. Chen, Chem. Rev. 110(2010) 3087-3111. doi: 10.1021/cr900361p
13. [13]
  X. Sun, Y. Li, T. Liu, et al., Adv. Drug. Deliv. Rev. 110-111(2017) 38-51. doi: 10.1016/j.addr.2016.06.007
14. [14]
  W. Cai, K. Chen, Z.B. Li, S.S. Gambhir, X. Chen, J. Nucl. Med. 48(2007) 1862-1870. doi: 10.2967/jnumed.107.043216
15. [15]
  S. Chaturvedi, A.K. Mishra, Front. Med. 3(2016) 5.
16. [16]
  J.C. Reubi, Endocr. Rev. 24(2003) 389-427. doi: 10.1210/er.2002-0007
17. [17]
  S.J. Hosseinimehr, V. Tolmachev, A. Orlova, Drug Discov. Today 17(2012) 1224-1232. doi: 10.1016/j.drudis.2012.07.002
18. [18]
  L.M. de León-Rodriguez, Z. Kovacs, G.R. Dieckmann, A.D. Sherry, Chemistry (Easton) 10(2004) 1149-1155.
19. [19]
  A. Razgulin, N. Ma, J. Rao, Chem. Soc. Rev. 40(2011) 4186-4216. doi: 10.1039/c1cs15035a
20. [20]
  E.W. Price, C. Orvig, Chem. Soc. Rev. 43(2014) 260-290. doi: 10.1039/C3CS60304K
21. [21]
  L. Zhu, K. Ploessl, H.F. Kung, Chem. Soc. Rev. 43(2014) 6683-6691. doi: 10.1039/C3CS60430F
22. [22]
  H. Chen, W. Zhang, G. Zhu, J. Xie, X. Chen, Nat. Rev. Mater. 2(2017) 17024. doi: 10.1038/natrevmats.2017.24
23. [23]
  H. Jadvar, Cancer Theranostics, Elsevier, 2014, pp. 45-54. doi: 10.1016/B978-0-12-407722-5.00017-7
24. [24]
  P. Shende, S. Gandhi, J. Drug Deliv. Sci. Technol. 64(2021) 102594. doi: 10.1016/j.jddst.2021.102594
25. [25]
  F. Maleki, A.M. Farahani, F. Rezazedeh, N. Sadeghzadeh, Bioorg. Chem. 99(2020) 103802. doi: 10.1016/j.bioorg.2020.103802
26. [26]
  Y. Dai, C. Xu, X. Sun, X. Chen, Chem. Soc. Rev. 46(2017) 3830-3852. doi: 10.1039/C6CS00592F
27. [27]
  S. Maschauer, J. Einsiedel, R. Haubner, et al., Angew. Chem. Int. Ed. 49(2010) 976-979. doi: 10.1002/anie.200904137
28. [28]
  C. Zhang, W. Wu, R.Q. Li, et al., Adv. Funct. Mater. 28(2018) 1804492. doi: 10.1002/adfm.201804492
29. [29]
  S. Banerjee, M.R.A. Pillai, F.F.R. Knapp, Chem. Rev. 115(2015) 2934-2974. doi: 10.1021/cr500171e
30. [30]
  Y. Liu, K. Ai, L. Lu, Acc. Chem. Res. 45(2012) 1817-1827. doi: 10.1021/ar300150c
31. [31]
  M.B. Mikulová, P. Mikuš, Pharmaceuticals 14(2021) 167. doi: 10.3390/ph14020167
32. [32]
  J.P. Meyer, P. Adumeau, J.S. Lewis, B.M. Zeglis, Bioconjug. Chem. 27(2016) 2791-2807. doi: 10.1021/acs.bioconjchem.6b00561
33. [33]
  J. Pellico, P.J. Gawne, R. T M de Rosales, Chem. Soc. Rev. 50(2021) 3355-3423. doi: 10.1039/D0CS00384K
34. [34]
  G. Yu, Z. Yang, X. Fu, et al., Nat. Commun. 9(2018) 766. doi: 10.1038/s41467-018-03119-w
35. [35]
  K. Kumar, A. Ghosh, Bioconjug. Chem. 29(2018) 953-975. doi: 10.1021/acs.bioconjchem.7b00817
36. [36]
  T. Opacic, V. Paefgen, T. Lammers, F. Kiessling, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 9(2017) e1441. doi: 10.1002/wnan.1420
37. [37]
  J.A. Jackson, I.N. Hungnes, M.T. Ma, C. Rivas, Bioconjug. Chem. 31(2020) 483-491. doi: 10.1021/acs.bioconjchem.0c00015
38. [38]
  L. Zhao, J. Zhu, Y. Cheng, et al., ACS Appl. Mater. Interfaces 7(2015) 19798-19808. doi: 10.1021/acsami.5b05836
39. [39]
  B. Pelaz, C. Alexiou, R.A. Alvarez-Puebl, et al., ACS Nano 11(2017) 2313-2381. doi: 10.1021/acsnano.6b06040
40. [40]
  M.S. Cooper, E. Sabbah, S.J. Mather, Nat. Protoc. 1(2006) 314-317. doi: 10.1038/nprot.2006.49
41. [41]
  J.K. Sosabowski, S.J. Mather, Nat. Protoc. 1(2006) 972-976. doi: 10.1038/nprot.2006.175
42. [42]
  C.L. Ferreira, D.T.T. Yapp, D. Mandel, et al., Bioconjug. Chem. 23(2012) 2239-2246. doi: 10.1021/bc300348d
43. [43]
  W.A.P. Breeman, E. de Blois, H. Sze Chan, et al., Nucl. Med. 41(2011) 314-321. doi: 10.1053/j.semnuclmed.2011.02.001
44. [44]
  C. Zhai, D. Summer, C. Rangger, et al., Mol. Pharm. 12(2015) 2142-2150. doi: 10.1021/acs.molpharmaceut.5b00128
45. [45]
  P. Ruzza, A. Calderan, Expert Opin. Med. Diagn. 5(2011) 411-424. doi: 10.1517/17530059.2011.592829
46. [46]
  M. Varani, F. Galli, S. Auletta, A. Signore, Clin. Transl. Imaging 6(2018) 271-292. doi: 10.1007/s40336-018-0283-x
47. [47]
  N. Goswami, Z. Luo, X. Yuan, D.T. Leong, J. Xie, Mater. Horiz. 4(2017) 817-831. doi: 10.1039/C7MH00451F
48. [48]
  Q. Chen, H. Wang, H. Liu, et al., Anal. Chem. 87(2015) 3949-3956. doi: 10.1021/acs.analchem.5b00135
49. [49]
  Y. Mizuno, T. Uehara, H. Hanaoka, et al., J. Med. Chem. 59(2016) 3331-3339. doi: 10.1021/acs.jmedchem.6b00024
50. [50]
  Y. Taira, T. Uehara, M. Tsuchiya, et al., Bioconjug. Chem. 29(2018) 459-466. doi: 10.1021/acs.bioconjchem.7b00788
51. [51]
  M. Fani, H.R. Maecke, Eur. J. Nucl. Med. Mol. Imaging 39(Suppl 1) (2012) S11-S30.
52. [52]
  K. Chen, P.S. Conti, Adv. Drug Deliv. Rev. 62(2010) 1005-1022. doi: 10.1016/j.addr.2010.09.004
53. [53]
  W. Wei, E.B. Ehlerding, X. Lan, Q. Luo, W. Cai, Eur. J. Nucl. Med. Mol. Imaging 45(2018) 132-150. doi: 10.1007/s00259-017-3839-5
54. [54]
  N.S. Goud, R.K. Joshi, R.D. Bharath, P. Kumar, Eur. J. Med. Chem. 187(2020) 111979. doi: 10.1016/j.ejmech.2019.111979
55. [55]
  J. Pellico, P.J. Gawne, R. T M de Rosales, Chem. Soc. Rev. 50(2021) 3355-3423. doi: 10.1039/D0CS00384K
56. [56]
  D.J. Worm, S. Els-Heindl, A.G. Beck-Sickinger, Peptide Science 24(2018) e3119. doi: 10.1002/psc.3119
57. [57]
  A. Iagaru, C. Mosci, B. Shen, et al., Radiology 273(2014) 549-559. doi: 10.1148/radiol.14140028
58. [58]
  A. Iagaru, C. Mosci, E. Mittr, et al., Radiology 277(2015) 497-506. doi: 10.1148/radiol.2015141550
59. [59]
  C.H. Nielsen, R.H. Kimura, N. Withofs, et al., Cancer Res. 70(2010) 9022-9030. doi: 10.1158/0008-5472.CAN-10-1338
60. [60]
  M. Schottelius, B. Laufer, H. Kessler, H.J. Wester, Acc. Chem. Res. 42(2009) 969-980. doi: 10.1021/ar800243b
61. [61]
  K. Temming, R.M. Schiffelers, G. Molema, R.J. Kok, Drug Resist. Updat. 8(2005) 381-402. doi: 10.1016/j.drup.2005.10.002
62. [62]
  Y. Zhang, K.Y. Park, K.F. Suazo, M.D. Distefano, Chem. Soc. Rev. 47(2018) 9106-9136. doi: 10.1039/C8CS00537K
63. [63]
  E.S. Mittra, M.L. Goris, A.H. Iagaru, et al., Radiology 260(2011) 182-191. doi: 10.1148/radiol.11101139
64. [64]
  Z. Liu, J. Shi, B. Jia, et al., Mol. Pharm. 8(2011) 591-599. doi: 10.1021/mp100403y
65. [65]
  E. Boros, C.L. Ferreira, D.T.T. Yapp, et al., Nucl. Med. Biol. 39(2012) 785-794. doi: 10.1016/j.nucmedbio.2012.01.003
66. [66]
  X. Sun, Y. Li, T. Liu, et al., Adv. Drug Deliv. Rev. 110-111(2017) 38-51. doi: 10.1016/j.addr.2016.06.007
67. [67]
  Z.B. Li, W. Cai, Q. Cao, et al., J. Nucl. Med. 48(2007) 1162-1171. doi: 10.2967/jnumed.107.039859
68. [68]
  Z. Wu, Z.B. Li, W. Cai, et al., Eur. J. Nucl. Med. Mol. Imaging 34(2007) 1823-1831. doi: 10.1007/s00259-007-0427-0
69. [69]
  R. Minamimoto, M. Jamali, A. Barkhodari, et al., Eur. J. Nucl. Med. Mol. Imaging 42(2015) 1850-1858. doi: 10.1007/s00259-015-3096-4
70. [70]
  R. Hernandez, H.F. Valdovinos, Y. Yang, et al., Mol. Pharm. 11(2014) 2954-2961. doi: 10.1021/mp500343j
71. [71]
  J. Notni, K. Pohle, H.J. Wester, Nucl. Med. Biol. 40(2013) 33-41. doi: 10.1016/j.nucmedbio.2012.08.006
72. [72]
  C. Imberti, S.Y.A. Terry, C. Cullinane, et al., Bioconjug. Chem. 28(2017) 481-495. doi: 10.1021/acs.bioconjchem.6b00621
73. [73]
  A.J. Beer, R. Haubner, M. Sarbia, et al., Clin. Cancer Res. 12(2006) 3942-3949. doi: 10.1158/1078-0432.CCR-06-0266
74. [74]
  K. Pohle, J. Notni, J. Bussemer, et al., Nucl. Med. Biol. 39(2012) 777-784. doi: 10.1016/j.nucmedbio.2012.02.006
75. [75]
  S. Sarkar, N. Bhatt, Y.S. Ha, et al., J. Med. Chem. 61(2018) 385-395. doi: 10.1021/acs.jmedchem.7b01671
76. [76]
  M. de Jong, W.A.P. Breeman, D.J. Kwekkeboom, R. Valkema, E.P. Krenning, Acc. Chem. Res. 42(2009) 873-880. doi: 10.1021/ar800188e
77. [77]
  M. Muttenthaler, G.F. King, D.J. Adams, P.F. Alewood, Nat. Rev. Drug Discov. 20(2021) 309-325. doi: 10.1038/s41573-020-00135-8
78. [78]
  R.P. Baum, A. Singh, M. Benešová, et al., Dalton Trans. 46(2017) 14638-14646. doi: 10.1039/C7DT01936J
79. [79]
  M.T. Ma, C. Cullinane, K. Waldeck, et al., EJNMMI Res. 5(2015) 52. doi: 10.1186/s13550-015-0131-1
80. [80]
  C. Müller, C. Vermeulen, K. Johnston, et al., EJNMMI Res. 6(2016) 35. doi: 10.1186/s13550-016-0189-4
81. [81]
  R.C. Walker, G.T. Smith, E. Liu, et al., J. Nucl. Med. 54(2013) 855-860. doi: 10.2967/jnumed.112.114165
82. [82]
  A. Sainz-Esteban, V. Prasad, C. Schuchardt, et al., Imaging 39(2012) 501-511. doi: 10.1007/s00259-011-2003-x
83. [83]
  D.J. Kwekkeboom, W.H. Bakker, P.P. Kooij, et al., Eur. J. Nucl. Med. 28(2001) 1319-1325. doi: 10.1007/s002590100574
84. [84]
  M. Essler, F.C. Gärtner, F. Neff, et al., Eur. J. Nucl. Med. Mol. Imaging 39(2012) 602-612. doi: 10.1007/s00259-011-2023-6
85. [85]
  D. Wild, J.S. Schmitt, M. Ginj, et al., Eur. J. Nucl. Med. Mol. Imaging 30(2003) 1338-1347. doi: 10.1007/s00259-003-1255-5
86. [86]
  D. Wild, M. Fani, M. Behe, et al., J. Nucl. Med. 52(2011) 1412-1417. doi: 10.2967/jnumed.111.088922
87. [87]
  L. Filippi, A. Chiaravalloti, O. Schillaci, R. Cianni, O. Bagni, Expert Rev. Med. Devices 17(2020) 331-343. doi: 10.1080/17434440.2020.1741348
88. [88]
  U. Hennrich, K. Kopka, Pharmaceuticals 12(2019) 114. doi: 10.3390/ph12030114
89. [89]
  Y. Miao, T. Shelton, T.P. Quinn, Cancer Biother. Radiopharm. 22(2007) 333-341. doi: 10.1089/cbr.2007.376.A
90. [90]
  L. Wei, X. Zhang, F. Gallazzi, et al., Nucl. Med. Biol. 36(2009) 345-354. doi: 10.1016/j.nucmedbio.2009.01.007
91. [91]
  M.F. Gibin, N. Wang, T.J. Hoffman, S.S. Jurisson, T.P. Quinn, Proc. Natl. Acad. Sci. U. S. A. 95(1998) 12814-12818. doi: 10.1073/pnas.95.22.12814
92. [92]
  P. McQuade, Y. Miao, J. Yoo, et al., J. Med. Chem. 48(2005) 2985-2992. doi: 10.1021/jm0490282
93. [93]
  G. Ren, Z. Liu, Z. Miao, et al., J. Nucl. Med. 50(2009) 1865-1872. doi: 10.2967/jnumed.109.062877
94. [94]
  J.W. Fletcher, B. Djulbegovic, H.P. Soares, et al., J. Nucl. Med. 49(2008) 480-508. doi: 10.2967/jnumed.107.047787
95. [95]
  Z. Cheng, L. Zhang, E. Graves, et al., J. Nucl. Med. 48(2007) 987-994. doi: 10.2967/jnumed.107.039602
96. [96]
  H. Guo, J. Yang, N. Shenoy, Y. Miao, Bioconjug. Chem. 20(2009) 2356-2363. doi: 10.1021/bc900428x
97. [97]
  J. Yang, J. Xu, R. Gonzalez, et al., Sci. Transl. Med. 10(2018) eaau4445. doi: 10.1126/scitranslmed.aau4445
98. [98]
  J.C. Garrison, T.L. Rold, G.L. Sieckman, et al., Bioconjug. Chem. 19(2008) 1803-1812. doi: 10.1021/bc8001375
99. [99]
  H. Zhang, J. Schuhmacher, B. Waser, et al., Eur. J. Nucl. Med. Mol. Imaging 34(2007) 1198-1208. doi: 10.1007/s00259-006-0347-4
100. [100]
  Z. Liu, J. Huang, C. Dong, et al., Mol. Pharm. 9(2012) 1409-1417. doi: 10.1021/mp200661t
101. [101]
  J. Zhang, G. Niu, L. Lang, et al., J. Nucl. Med. 58(2017) 228-234. doi: 10.2967/jnumed.116.177048
102. [102]
  Z. Liu, Z.B. Li, Q. Cao, et al., J. Nucl. Med. 50(2009) 1168-1177. doi: 10.2967/jnumed.108.061739
103. [103]
  B.J. Hackel, R.H. Kimura, Z. Miao, et al., J. Nucl. Med. 54(2013) 1101-1105. doi: 10.2967/jnumed.112.110759
104. [104]
  L. Jiang, Y. Tu, R.H. Kimura, et al., J. Nucl. Med. 56(2015) 939-944. doi: 10.2967/jnumed.115.155176
105. [105]
  C.H. Nielsen, R.H. Kimura, N. Withofs, et al., Cancer Res. 70(2010) 9022-9030. doi: 10.1158/0008-5472.CAN-10-1338
106. [106]
  X. Sun, W. Cai, X. Chen, Acc. Chem. Res. 48(2015) 286-294. doi: 10.1021/ar500362y
107. [107]
  J. Li, X. Chang, X. Chen, et al., Biotechnol. Adv. 32(2014) 727-743. doi: 10.1016/j.biotechadv.2013.12.009
108. [108]
  F. Gao, P. Cai, W. Yang, et al., ACS Nano 9(2015) 4976-4986. doi: 10.1021/nn507130k
109. [109]
  W. Fan, B. Yung, P. Huang, X. Chen, Chem. Rev. 117(2017) 13566-13638. doi: 10.1021/acs.chemrev.7b00258
110. [110]
  W. Fan, W. Tang, J. Lau, et al., Adv. Mater. 31(2019) e1806381. doi: 10.1002/adma.201806381
111. [111]
  J.M. Kinsella, R.E. Jimenez, P.P. Karmali, et al., Angew. Chem. Int. Ed. 50(2011) 12308-12311. doi: 10.1002/anie.201104507
112. [112]
  C. Sun, J.S.H. Lee, M. Zhang, Adv. Drug Deliv. Rev. 60(2008) 1252-1265. doi: 10.1016/j.addr.2008.03.018
113. [113]
  A.S. Krupnick, V.K. Tidwell, J.A. Engelbach, et al., Nat. Protoc. 7(2012) 128-142. doi: 10.1038/nprot.2011.424
114. [114]
  H. Arami, A. Khandhar, D. Liggitt, K.M. Krishnan, Chem. Soc. Rev. 44(2015) 8576-8607. doi: 10.1039/C5CS00541H
115. [115]
  H.Y. Lee, Z. Li, K. Chen, et al., J. Nucl. Med. 49(2008) 1371-1379. doi: 10.2967/jnumed.108.051243
116. [116]
  I. Velikyan, Cancer Theranostics, Elsevier, 2014, pp. 285-325. doi: 10.1016/B978-0-12-407722-5.00017-7
117. [117]
  A.K. Hauser, M.I. Mitov, E.F. Daley, et al., Biomaterials 105(2016) 127-135. doi: 10.1016/j.biomaterials.2016.07.032
118. [118]
  I.A. Khawar, J.H. Kim, H.J. Kuh, J. Control. Release 201(2015) 78-89. doi: 10.1016/j.jconrel.2014.12.018
119. [119]
  L. Hao, N. Rohani, R.T. Zhao, et al., Nat. Mater. (2021) 201440-201448. doi: 10.1038/s41563-021-01042-y
120. [120]
  R.H. Kimura, L. Wang, B. Shen, et al., Nat. Commun. 10(2019) 4673. doi: 10.1038/s41467-019-11863-w
121. [121]
  Q. Wang, N. Jiang, B. Fu, F. Huang, J. Liu, Biomater. Sci. 7(2019) 4888-4911. doi: 10.1039/C9BM01212E
122. [122]
  H. Sun, B. Zhang, X. Jiang, et al., Nanomedicine 14(2019) 5-17. doi: 10.2217/nnm-2018-0219
123. [123]
  X. Gu, Z. Zhu, Q. Fan, et al., Small 15(2019) e1902577. doi: 10.1002/smll.201902577
124. [124]
  X. Yang, H. Hong, J.J. Grailer, et al., Biomaterials 32(2011) 4151-4160. doi: 10.1016/j.biomaterials.2011.02.006
125. [125]
  Y. Zhao, B. Pang, H. Luehmann, et al., Adv. Healthc. Mater. 5(2016) 928-935. doi: 10.1002/adhm.201500992
126. [126]
  S. Sachindra, T. Hellberg, S. Exner, et al., Front. Oncol. 11(2021) 684713. doi: 10.3389/fonc.2021.684713
127. [127]
  X. Zhang, R. Liu, Q. Yuan, et al., ACS Nano 12(2018) 11139-11151. doi: 10.1021/acsnano.8b05584
128. [128]
  M. Zhao, J. Ding, Q. Mao, et al., Nanoscale 12(2020) 6953-6958. doi: 10.1039/C9NR10720G
129. [129]
  L. Yin, H. Sun, H. Zhang, et al., J. Am. Chem. Soc. 141(2019) 3265-3273. doi: 10.1021/jacs.8b13628
1. [1]
  Chuanfeng Fan , Jian Gao , Yingkai Gao , Xintong Yang , Gaoning Li , Xiaochun Wang , Fei Li , Jin Zhou , Haifeng Yu , Yi Huang , Jin Chen , Yingying Shan , Li Chen . A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging. Chinese Chemical Letters, 2024, 35(10): 109838-. doi: 10.1016/j.cclet.2024.109838
2. [2]
  Jianhui Yin , Wenjing Huang , Changyong Guo , Chao Liu , Fei Gao , Honggang Hu . Tryptophan-specific peptide modification through metal-free photoinduced N-H alkylation employing N-aryl glycines. Chinese Chemical Letters, 2024, 35(6): 109244-. doi: 10.1016/j.cclet.2023.109244
3. [3]
  Jing-Jing Zhang , Lujun Lou , Rui Lv , Jiahui Chen , Yinlong Li , Guangwei Wu , Lingchao Cai , Steven H. Liang , Zhen Chen . Recent advances in photochemistry for positron emission tomography imaging. Chinese Chemical Letters, 2024, 35(8): 109342-. doi: 10.1016/j.cclet.2023.109342
4. [4]
  Bin Fang , Jiaqi Yang , Limin Wang , Haoqin Li , Jiaying Guo , Jiaxin Zhang , Qingyuan Guo , Bo Peng , Kedi Liu , Miaomiao Xi , Hua Bai , Li Fu , Lin Li . A mitochondria-targeted H₂S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury. Chinese Chemical Letters, 2024, 35(6): 108913-. doi: 10.1016/j.cclet.2023.108913
5. [5]
  Zengchao Guo , Weiwei Liu , Tengfei Liu , Jinpeng Wang , Hui Jiang , Xiaohui Liu , Yossi Weizmann , Xuemei Wang . Engineered exosome hybrid copper nanoscale antibiotics facilitate simultaneous self-assembly imaging and elimination of intracellular multidrug-resistant superbugs. Chinese Chemical Letters, 2024, 35(7): 109060-. doi: 10.1016/j.cclet.2023.109060
6. [6]
  Lixian Fu , Yiyun Tan , Yue Ding , Weixia Qing , Yong Wang . Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label. Chinese Chemical Letters, 2024, 35(4): 108886-. doi: 10.1016/j.cclet.2023.108886
7. [7]
  Yunlong Li , Xinyu Zhang , Shuang Liu , Chunsheng Li , Qiang Wang , Jin Ye , Yong Lu , Jiating Xu . Engineered iron-based metal-organic frameworks nanoplatforms for cancer theranostics: A mini review. Chinese Chemical Letters, 2025, 36(2): 110501-. doi: 10.1016/j.cclet.2024.110501
8. [8]
  Haixian Ren , Yuting Du , Xiaojing Yang , Fangjun Huo , Le Zhang , Caixia Yin . Development of ESIPT-based specific fluorescent probes for bioactive species based on the protection-deprotection of the hydroxyl. Chinese Chemical Letters, 2025, 36(2): 109867-. doi: 10.1016/j.cclet.2024.109867
9. [9]
  Fan Zheng , Runsha Xiao , Shuai Huang , Zhikang Chen , Chen Lai , Anyao Bi , Heying Yao , Xueping Feng , Zihua Chen , Wenbin Zeng . Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe. Chinese Chemical Letters, 2025, 36(2): 109876-. doi: 10.1016/j.cclet.2024.109876
10. [10]
  Yixuan Zhu , Qingtong Wang , Jin Li , Lin Chen , Junlong Zhao . Blog of Oxytocin. University Chemistry, 2024, 39(9): 134-140. doi: 10.12461/PKU.DXHX202310090
11. [11]
  Weiyu Chen , Zenghui Li , Chenguang Zhao , Lisha Zha , Junfeng Shi , Dan Yuan . Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery. Chinese Chemical Letters, 2024, 35(12): 109628-. doi: 10.1016/j.cclet.2024.109628
12. [12]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
13. [13]
  Rui Wang , He Qi , Haijiao Zheng , Qiong Jia . Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment. Chinese Chemical Letters, 2024, 35(7): 109215-. doi: 10.1016/j.cclet.2023.109215
14. [14]
  Cheng-Yan Wu , Yi-Nan Gao , Zi-Han Zhang , Rui Liu , Quan Tang , Zhong-Lin Lu . Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages. Chinese Chemical Letters, 2024, 35(11): 109649-. doi: 10.1016/j.cclet.2024.109649
15. [15]
  Kun Zhang , Ni Dan , Dan-Dan Ren , Ruo-Yu Zhang , Xiaoyan Lu , Ya-Pan Wu , Li-Lei Zhang , Hong-Ru Fu , Dong-Sheng Li . A small D-A molecule with highly heat-resisting room temperature phosphorescence for white emission and anti-counterfeiting. Chinese Journal of Structural Chemistry, 2024, 43(3): 100244-100244. doi: 10.1016/j.cjsc.2024.100244
16. [16]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
17. [17]
  Chaoqun Ma , Yuebo Wang , Ning Han , Rongzhen Zhang , Hui Liu , Xiaofeng Sun , Lingbao Xing . Carbon dot-based artificial light-harvesting systems with sequential energy transfer and white light emission for photocatalysis. Chinese Chemical Letters, 2024, 35(4): 108632-. doi: 10.1016/j.cclet.2023.108632
18. [18]
  Bohan Zhang , Bingzhe Wang , Guichuan Xing , Zikang Tang , Songnan Qu . Regulation of the multi-emission centers in carbon dots via a bottom-up synthesis approach. Chinese Chemical Letters, 2024, 35(9): 109358-. doi: 10.1016/j.cclet.2023.109358
19. [19]
  Xingwen Cheng , Haoran Ren , Jiangshan Luo . Boosting the self-trapped exciton emission in vacancy-ordered double perovskites via supramolecular assembly. Chinese Journal of Structural Chemistry, 2024, 43(6): 100306-100306. doi: 10.1016/j.cjsc.2024.100306
20. [20]
  Yi Liu , Peng Lei , Yang Feng , Shiwei Fu , Xiaoqing Liu , Siqi Zhang , Bin Tu , Chen Chen , Yifan Li , Lei Wang , Qing-Dao Zeng . Topologically engineering of π-conjugated macrocycles: Tunable emission and photochemical reaction toward multi-cyclic polymers. Chinese Chemical Letters, 2024, 35(10): 109571-. doi: 10.1016/j.cclet.2024.109571

Get Citation

PDF

XML

Metrics

PDF Downloads(30)
Abstract views(756)
HTML views(13)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142