Citation: Yanyan Sun, Xiaonan Zhou, Liyuan Sun, Xiuxiu Zhao, Yongrui He, Ge Gao, Weina Han, Jin Zhou. Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells[J]. Chinese Chemical Letters, ;2022, 33(9): 4229-4232. doi: 10.1016/j.cclet.2022.01.087 shu

Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells

Yanyan Sun ^{a, 1} ,
Xiaonan Zhou ^{b, 1} ,
Liyuan Sun ^a ,
Xiuxiu Zhao ^a ,
Yongrui He ^a ,
Ge Gao ^{a, *,} ,
Weina Han ^a ,
Jin Zhou ^{a, *,}

a.
School of Pharmacy, School of Rehabilitation Medicine, Weifang Medical University, Weifang 261053, China
b.
Weifang Maternal and Child Health Hospital, Maternal and Child Health Hospital of Weifang Medical University, Weifang 261011, China

gaoge@wfmc.edu.cn

zhoujin@wfmc.edu.cn

Received Date: 21 October 2021
Revised Date: 27 January 2022
Accepted Date: 29 January 2022
Available Online: 4 February 2022

Figures(4)

Available online The abnormal carboxylesterase (CES) expression is closely related to many diseases such as hyperlipidemia, atherosclerosis, obesity, liver cancer, type 2 diabetes mellitus and gastrointestinal stromal tumors. The detection of a single enzyme in practical samples is often constrained by the structural diversity of CESs. Thus, the development of broad-carboxylesterase responsive fluorescent probe, which can detect the presence of wide variety of CESs, may provide overall or category information from another point of view, supplementing the deficiency of single detection for CES subspecies. Organelle lysosome is involved in various cell processes, such as cell signaling, apoptosis, secretion, and energy metabolism. Up to date, lysosome-targeted fluorescent probes, especially those with red emission (over 550 nm, with relatively low biological harmfulness), for CES detection are still rare. A lysosomes-targeted red fluorescent probe CES-Lyso was designed to monitor intracellular a variety of carboxylesterases alteration with wonderful selectivity and sensitivity, which was further applied to distinguish different derived breast cancer cells and monitor carboxylesterase activity in the anticancer drug treatment.
- Fluorescent probe,
- Carboxylesterases,
- Broad detection,
- Breast cancer,
- Lysosome-targeting,
- Red fluorescence
1. [1]
  M. Li, C. Zhai, S. Wang, et al., RSC Adv. 9 (2019) 40689-40693. doi: 10.1039/c9ra08150j
2. [2]
  A. Jiang, G. Chen, J. Xu, et al., Chem. Commun. 55 (2019) 11358-11361. doi: 10.1039/c9cc05759e
3. [3]
  Z. Tian, L. Ding, K. Li, et al., Anal. Chem., 91 (2019) 5638-5645. doi: 10.1021/acs.analchem.8b05417
4. [4]
  B. Shen, X. Zhang, J. Dai, et al., J. Hazard. Mater. 407 (2021) 124342. doi: 10.1016/j.jhazmat.2020.124342
5. [5]
  J. Dai, Y. Hou, J. Wu, et al., ChemistrySelect 5 (2020) 11185-11196. doi: 10.1002/slct.202002625
6. [6]
  J. Kan, X. Zhou, Y. Sun, et al., Chin. Chem. Lett. 32 (2021) 3066-3070. doi: 10.1016/j.cclet.2021.03.076
7. [7]
  C. Zhang, H. Xie, T. Zhan, et al., Chem. Commun. 55 (2019) 9444-9447. doi: 10.1039/c9cc03909k
8. [8]
  H.Y. Li, J.F. Chang, W.X. Lyu, et al., Chin. J. Anal. Chem. 48 (2020) 1325-1333. doi: 10.1016/S1872-2040(20)60051-2
9. [9]
  H. Li, H. Lin, W. Lv, et al., Biosens. Bioelectron. 165 (2020) 112336. doi: 10.1016/j.bios.2020.112336
10. [10]
  S. Wang, B. Zhu, B. Wang, et al., Chin. Chem. Lett. 32 (2021) 1795-1798. doi: 10.1016/j.cclet.2020.12.039
11. [11]
  H. Chu, L. Yang, L. Yu, et al., Coord. Chem. Rev. 449 (2021) 214208. doi: 10.1016/j.ccr.2021.214208
12. [12]
  S.D. Kodani, M. Barthélemy, S.G. Kamita, et al., Anal. Biochem. 539 (2017) 81-89. doi: 10.1016/j.ab.2017.10.014
13. [13]
  C. Ma, J. Wu, W. Sun, et al., Sens. Actuators B: Chem. 325 (2020) 128798. doi: 10.1016/j.snb.2020.128798
14. [14]
  B. Shen, C. Ma, Y. Ji, et al., ACS Appl. Mater. Interfaces 13 (2021) 8718-8726. doi: 10.1021/acsami.0c19811
15. [15]
  X.Y. Zhang, T.T. Liu, J.H. Liang, et al., J. Mater. Chem. B. 9 (2021) 2457-2461. doi: 10.1039/d0tb02673e
16. [16]
  Y. Wang, F. Yu, X. Luo, et al., Chem. Commun. 56 (2020) 4412-4415. doi: 10.1039/d0cc00297f
17. [17]
  S.J. Park, Y.J. Kim, J.S. Kang, et al., Anal. Chem. 90 (2018) 9465-9471. doi: 10.1021/acs.analchem.8b02101
18. [18]
  A. Singh, M. Gao, M.W. Beck, et al., RSC Med. Chem. 12 (2021) 1142-1153. doi: 10.1039/d1md00073j
19. [19]
  H. Zhou, J. Tang, J. Zhang, et al., J. Mater. Chem. B 7 (2019) 2989-2996. doi: 10.1039/c9tb00310j
20. [20]
  S. Samanta, S. Halder, G. Das, et al., Anal. Chem. 90 (2018) 7561-7568. doi: 10.1021/acs.analchem.8b01181
21. [21]
  B. Chen, S. Mao, Y. Sun, et al., Chem. Commun. 57 (2021) 4376-4379. doi: 10.1039/d1cc01104a
22. [22]
  B. Chen, C. Li, J. Zhang, et al., Chem. Commun. 55 (2019) 7410-7413. doi: 10.1039/c9cc03977e
23. [23]
  Z. Chai, D. Liu, X. Li, et al., Chem. Commun. 57 (2021) 5063-5066. doi: 10.1039/d1cc01462e
24. [24]
  Y. Lu, J. Xu, Z. Jia, et al., Chin. Chem. Lett. 33 (2022) 1589–1594. doi: 10.1016/j.cclet.2021.09.013
25. [25]
  X. Chai, W. Zhu, Q. Meng, et al., Chin. Chem. Lett. 32 (2021) 210-213. doi: 10.1016/j.cclet.2020.11.032
26. [26]
  D. Bu, Y. Wang, N. Wu, et al., Chin. Chem. Lett. 32 (2021) 1799-1802. doi: 10.1016/j.cclet.2020.12.044
27. [27]
  G. Li, J. Wang, D. Li, et al., Chin. Chem. Lett. 32 (2021) 1527-1531. doi: 10.1016/j.cclet.2020.09.040
28. [28]
  W.Y. Guo, Y.X. Fu, S.Y. Liu, et al., Anal. Chem. 93 (2021) 7079-7085. doi: 10.1021/acs.analchem.1c00553
29. [29]
  Y.H. Lee, N. Park, Y.B. Park, et al., Chem. Commun. 50 (2014) 3197-3200. doi: 10.1039/C4CC00091A
30. [30]
  A. Sharma, E.J. Kim, H. Shi, et al., Biomaterials 155 (2018) 145-151. doi: 10.1016/j.biomaterials.2017.11.019
31. [31]
  H. Lee, S. Uhm, J. -W. Shin, et al., Chem. Asian J. 10 (2015) 2695-2700. doi: 10.1002/asia.201500913
32. [32]
  S. Dongbang, H.M. Jeon, M.H. Lee, et al., RSC Adv. 4 (2014) 18744-18748. doi: 10.1039/c4ra02588a
1. [1]
  Huamei Zhang , Jingjing Liu , Mingyue Li , Shida Ma , Xucong Zhou , Aixia Meng , Weina Han , Jin Zhou . Imaging polarity changes in pneumonia and lung cancer using a lipid droplet-targeted near-infrared fluorescent probe. Chinese Chemical Letters, 2024, 35(12): 110020-. doi: 10.1016/j.cclet.2024.110020
2. [2]
  Fan Zheng , Runsha Xiao , Shuai Huang , Zhikang Chen , Chen Lai , Anyao Bi , Heying Yao , Xueping Feng , Zihua Chen , Wenbin Zeng . Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe. Chinese Chemical Letters, 2025, 36(2): 109876-. doi: 10.1016/j.cclet.2024.109876
3. [3]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
4. [4]
  Yudi Cheng , Xiao Wang , Jiao Chen , Zihan Zhang , Jiadong Ou , Mengyao She , Fulin Chen , Jianli Li . A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H₂S and its applications in living system. Chinese Chemical Letters, 2024, 35(5): 109156-. doi: 10.1016/j.cclet.2023.109156
5. [5]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862
6. [6]
  Chuanfeng Fan , Jian Gao , Yingkai Gao , Xintong Yang , Gaoning Li , Xiaochun Wang , Fei Li , Jin Zhou , Haifeng Yu , Yi Huang , Jin Chen , Yingying Shan , Li Chen . A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging. Chinese Chemical Letters, 2024, 35(10): 109838-. doi: 10.1016/j.cclet.2024.109838
7. [7]
  Lei Shen , Hongmei Liu , Ming Jin , Jinchao Zhang , Caixia Yin , Shuxiang Wang , Yutao Yang . “Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone. Chinese Chemical Letters, 2024, 35(10): 109572-. doi: 10.1016/j.cclet.2024.109572
8. [8]
  Han-Min Wang , Yan-Chen Li , Lu-Lu Sun , Ming-Ye Tang , Jia Liu , Jiahao Cai , Lei Dong , Jia Li , Yi Zang , Hai-Hao Han , Xiao-Peng He . Protein-encapsulated long-wavelength fluorescent probe hybrid for imaging lipid droplets in living cells and mice with non-alcoholic fatty liver. Chinese Chemical Letters, 2024, 35(11): 109603-. doi: 10.1016/j.cclet.2024.109603
9. [9]
  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
10. [10]
  Jiajia Lv , Jie Gao , Hongyu Li , Zeli Yuan , Nan Dong . Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo. Chinese Chemical Letters, 2024, 35(5): 108940-. doi: 10.1016/j.cclet.2023.108940
11. [11]
  Chao Liu , Chao Jia , Shi-Xian Gan , Qiao-Yan Qi , Guo-Fang Jiang , Xin Zhao . A luminescent one-dimensional covalent organic framework for organic arsenic sensing in water. Chinese Chemical Letters, 2024, 35(11): 109750-. doi: 10.1016/j.cclet.2024.109750
12. [12]
  Yunkang Tong , Haiqiao Huang , Haolan Li , Mingle Li , Wen Sun , Jianjun Du , Jiangli Fan , Lei Wang , Bin Liu , Xiaoqiang Chen , Xiaojun Peng . Cooperative bond scission by HRP/H₂O₂ for targeted prodrug activation. Chinese Chemical Letters, 2024, 35(12): 109663-. doi: 10.1016/j.cclet.2024.109663
13. [13]
  Quan Zhang , Shunjie Xing , Jingqian Han , Li Feng , Jianchun Li , Zhaosheng Qian , Jin Zhou . Organic pollutant sensing for human health based on carbon dots. Chinese Chemical Letters, 2025, 36(1): 110117-. doi: 10.1016/j.cclet.2024.110117
14. [14]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
15. [15]
  Lixian Fu , Yiyun Tan , Yue Ding , Weixia Qing , Yong Wang . Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label. Chinese Chemical Letters, 2024, 35(4): 108886-. doi: 10.1016/j.cclet.2023.108886
16. [16]
  Gaojian Yang , Zhiyang Li , Rabia Usman , Zhu Chen , Yuan Liu , Song Li , Hui Chen , Yan Deng , Yile Fang , Nongyue He . DNA walker induced "signal on" fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer. Chinese Chemical Letters, 2025, 36(2): 109930-. doi: 10.1016/j.cclet.2024.109930
17. [17]
  Jialin Xie , Qing Feng , Zhen Li , Jinyi Yang , Min Liu , Wei Qi . Life’s Guardian Angel: Progesterone. University Chemistry, 2024, 39(10): 416-419. doi: 10.12461/PKU.DXHX202403068
18. [18]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
19. [19]
  Meiling Xu , Xinyang Li , Pengyuan Liu , Junjun Liu , Xiao Han , Guodong Chai , Shuangling Zhong , Bai Yang , Liying Cui . A novel and visible ratiometric fluorescence determination of carbaryl based on red emissive carbon dots by a solvent-free method. Chinese Chemical Letters, 2025, 36(2): 109860-. doi: 10.1016/j.cclet.2024.109860
20. [20]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(626)
HTML views(76)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142