Citation: Jixin Li, Zhirong Cui, Yongyi Li, Chunhua Han, Yanqiu Zhang, Pengfei Tang, Letian Cui, Hao Zhang, Jun Luo, Lingyi Kong. Chlospicenes A and B, cyclopropane cracked lindenane sesquiterpenoid dimers with anti-nonalcoholic steatohepatitis activity from Chloranthus henryi[J]. Chinese Chemical Letters, ;2022, 33(9): 4257-4260. doi: 10.1016/j.cclet.2022.01.084 shu

Chlospicenes A and B, cyclopropane cracked lindenane sesquiterpenoid dimers with anti-nonalcoholic steatohepatitis activity from Chloranthus henryi

Jixin Li ^{a, b} ,
Zhirong Cui ^a ,
Yongyi Li ^a ,
Chunhua Han ^a ,
Yanqiu Zhang ^a ,
Pengfei Tang ^a ,
Letian Cui ^a ,
Hao Zhang ^a ,
Jun Luo ^{a, *,} ,
Lingyi Kong ^{a, *,}

a.
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
b.
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

luojun@cpu.edu.cn

cpu_lykong@126.com

Received Date: 17 October 2021
Revised Date: 25 January 2022
Accepted Date: 27 January 2022
Available Online: 7 February 2022

Figures(6)

Guided by MS/MS molecular networks strategy, chlospicenes A and B (1 and 2), the first example of cyclopropane moiety cracked lindenane sesquiterpene Michael addition dimers, along with their biogenetic analogues (3 and 4), were targetedly discovered from the roots of Chloranthus henryi. Their structures including absolute configurations were characterized by NMR, ECD and X-ray diffraction analysis. The plausible biogenic pathway speculation indicated that cyclopropylcarbinyl rearrangement may dominate the key crack of cyclopropane moiety. In addition, compounds 1 and 2 showed significant anti-nonalcoholic steatohepatitis (NASH) activity in free fatty acid (FFA)-induced HepG2 cells by decreasing intracellular lipid accumulation.
- Chloranthus henryi.,
- Lindenane sesquiterpenoid dimer,
- Molecular networks,
- Cyclopropylcarbinyl rearrangement,
- Anti-nonalcoholic steatohepatitis
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