Citation: Mengfei Hou, Wandi Chen, Junkai Zhao, Deshen Dai, Mo Yang, Changqing Yi. Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles[J]. Chinese Chemical Letters, ;2022, 33(8): 4101-4106. doi: 10.1016/j.cclet.2022.01.049 shu

Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles

Mengfei Hou ^{a, 1} ,
Wandi Chen ^{a, 1} ,
Junkai Zhao ^{a, b, 1} ,
Deshen Dai ^a ,
Mo Yang ^c ,
Changqing Yi ^{a, *,}

a.
Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical Devices, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
b.
State Key Laboratory of Oncology in South China, Collaborative Innovation Center For Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
c.
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China

yichq@mail.sysu.edu.cn

Received Date: 28 August 2021
Revised Date: 16 January 2022
Accepted Date: 17 January 2022
Available Online: 23 January 2022

Figures(5)

Fluorescence (FL) imaging guided photodynamic therapy (PDT) is becoming highly desirable for personalized therapy and precision medicine. In this study, fluorescent polymer nanoparticles TCPP@PEI/PGA were facilely synthesized through electrostatic interaction-mediated self-assembly of porphyrins tetra(4-carboxyphenyl)porphine (TCPP) and polyethylenimine (PEI), and subsequent surface modification with γ-poly(glutamic acid) (γ-PGA). TCPP served a dual function as the FL imaging probe and the photosensitizer. The as-prepared TCPP@PEI/PGA nanoparticles showed excellent water-solubility and biocompatibility, while having outstanding capabilities of in vivo bioimaging and ¹O₂ generation. FL bioimaging of mice and effective killing of CT 26 cells as well as CT 26 tumor-bearing mice upon laser irradiation were successfully demonstrated when using TCPP@PEI/PGA as theranostic nanoprobes. This study provides a simple but robust method to design and synthesize porphyrin-based polymer nanoparticles for theranostics.
- Porphyrins,
- Fluorescence imaging,
- Photodynamic therapy,
- Theranostics
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沈阳化工大学材料科学与工程学院沈阳 110142