Citation: Huan Liu, Zhong-Jian Cai, Shun-Jun Ji. Access to 3-alkylselenindoles by multicomponent reaction of indoles, selenium powder and unactivated alkyl halides under transition-metal-free conditions[J]. Chinese Chemical Letters, ;2022, 33(9): 4303-4305. doi: 10.1016/j.cclet.2022.01.046 shu

Access to 3-alkylselenindoles by multicomponent reaction of indoles, selenium powder and unactivated alkyl halides under transition-metal-free conditions

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China

zjcai@suda.edu.cn

shunjun@suda.edu.cn

Received Date: 26 November 2021
Revised Date: 13 January 2022
Accepted Date: 16 January 2022
Available Online: 22 January 2022

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Herein, we reported a convenient and efficient multicomponent reaction of indoles, selenium powder and unactivated alkyl halides. This protocol provides a practical, and facile approach for the synthesis of 3-alkylselenindole derivatives. The advantages of this strategy include mild and transition-metal-free conditions, broad functional group tolerance, the use of simple and easily accessible seleniium powder and alkyl halides as coupling partners. More importantly, the reaction proceeded smoothly with a large scale (> 10 g, > 90% yield), which further highlighted the potential application of this selenation strategy.
- Selenium,
- 3-Alkylselenindole,
- Indole,
- Selenization
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