Citation: Lixia Wang, Jikun Li, Junfeng Xiang, Jie Cui, Yalin Tang. Kinetic characterization of a slow chemical exchange between two sites in N, N-dimethylacetylamide by CEST NMR spectroscopy[J]. Chinese Chemical Letters, ;2022, 33(9): 4335-4338. doi: 10.1016/j.cclet.2022.01.022 shu

Kinetic characterization of a slow chemical exchange between two sites in N, N-dimethylacetylamide by CEST NMR spectroscopy

Lixia Wang ^a ,
Jikun Li ^a ,
Junfeng Xiang ^{a, b, *,} ,
Jie Cui ^a ,
Yalin Tang ^{a, b, *,}

a.
Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China

jfxiang@iccas.ac.cn

tangyl@iccas.ac.cn

Received Date: 5 October 2021
Revised Date: 9 January 2022
Accepted Date: 9 January 2022
Available Online: 15 January 2022

Figures(6)

Nuclear magnetic resonance (NMR) spectroscopy has provided many powerful tools for the study of dynamic processes. Among the reported methods, chemical exchange saturation transfer (CEST) is more suitable for systems with slow exchange rates, and there will be promising in the detection and dynamic mechanism of metastable substances. It has been widely used in magnetic resonance imaging (MRI), however whether it is applicable in the field of chemical kinetics needs more examples. Here we studied, as a proof of concept, the kinetics of the slow chemical exchange between the two N-methyl protons of N, N-dimethylacetylamide (DMA), exploiting QUantifying Exchange using Z-spectrum (QUEZS) and QUantifying Exchange using Saturation Time (QUEST) methods. It turned out that both of QUEZS and QUEST could give the corresponding exchange rates, showcasing the capability of this method to provide accurate kinetic data under a range of temperatures. Our results clearly demonstrated the reliability of CEST-based techniques as a tool for dynamic kinetics by NMR.
- Chemical exchange saturation transfer (CEST),
- Chemical exchange,
- N, N-Dimethylacetylamid,
- Bloch-McConnell equation,
- Dynamic kinetics
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