Citation: Tianjiao Zhou, Yuan Xu, Yuehong Gong, Mingtao Yu, Enzhen Xu, Wusimanjiang Aimaiti, Ruijia Ma, Lei Xing, Hao Wen, Jianhua Wang, Hulin Jiang. Breaking-then-curing strategy for efficient cystic echinococcosis therapy[J]. Chinese Chemical Letters, ;2022, 33(6): 2949-2953. doi: 10.1016/j.cclet.2021.12.098 shu

Breaking-then-curing strategy for efficient cystic echinococcosis therapy

Tianjiao Zhou ^{a, 1} ,
Yuan Xu ^{a, 1} ,
Yuehong Gong ^{b, c, 1} ,
Mingtao Yu ^a ,
Enzhen Xu ^a ,
Wusimanjiang Aimaiti ^c ,
Ruijia Ma ^c ,
Lei Xing ^a ,
Hao Wen ^{b, *,} ,
Jianhua Wang ^{b, c, *,} ,
Hulin Jiang ^{a, c, *,}

a.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
b.
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
c.
College of Pharmaceutical Sciences, Xinjiang Medical University, Urumqi 830011, China

dr.wenhao@163.com

jhw716@163.com

jianghulin3@163.com

Received Date: 30 September 2021
Revised Date: 22 December 2021
Accepted Date: 31 December 2021
Available Online: 7 January 2022

Figures(5)

Cystic echinococcosis (CE) is one of the most harmful and life-threatening helminths. As the essential therapeutics, chemotherapy is always difficult to achieve desired anti-echinococcal effect due to the problems that the echinococcus granulosus cyst laminated layer makes the drug difficult to infiltrate and the poor solubility of drugs. In this study, we established a "breaking-then-curing" anti-echinococcal treatment strategy for efficient CE therapy. The photodynamic therapy (PDT) was used as a breaker to produce toxic reactive oxygen species (ROS) and damage the laminated layer of protoscolices (PSCs), leading to enhanced infiltration of albendazole sulfoxide nanoparticles (ABZSO NPs). Then, ABZSO NP was worked as curer for efficient anti-echinococcal treatment. As a result, the breaking-then-curing treatment strategy could generate more intracellular ROS in PSCs induced by plenty of ABZSO NPs, greatly increasing the mortality rate of PSCs in a shorter time than using ABZSO NPs alone, leading to the attenuation of laminated layer and finally disintegrating PSCs. We believe the "breaking-then-curing" strategy will suggest great potential in the treatment of CE and provide a new sight for anti-echinococcal treatment.
- Cystic echinococcosis,
- Photodynamic therapy,
- Albendazole sulfoxide,
- Protoscolex,
- Nanoparticles
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