Citation: Fan Jiang, Chunzheng Yang, Binbin Ding, Shuang Liang, Yajie Zhao, Ziyong Cheng, Min Liu, Bengang Xing, Ping'an Ma, Jun Lin. Tumor microenvironment-responsive MnSiO₃-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy[J]. Chinese Chemical Letters, ;2022, 33(6): 2959-2964. doi: 10.1016/j.cclet.2021.12.096 shu

Tumor microenvironment-responsive MnSiO₃-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy

Fan Jiang ^{a, b} ,
Chunzheng Yang ^{a, b} ,
Binbin Ding ^{a, b} ,
Shuang Liang ^{a, b} ,
Yajie Zhao ^{a, b} ,
Ziyong Cheng ^{a, b} ,
Min Liu ^c ,
Bengang Xing ^d ,
Ping'an Ma ^{a, b, *,} ,
Jun Lin ^{a, b, *,}

a.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
c.
Department of Periodontology, Stomatological Hospital, Jilin University, Changchun 130021, China
d.
School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 639798, Singapore

mapa675@ciac.ac.cn

jlin@ciac.ac.cn

Received Date: 14 September 2021
Revised Date: 17 December 2021
Accepted Date: 31 December 2021
Available Online: 7 January 2022

Figures(5)

Compared with traditional photodynamic therapy (PDT), ultrasound (US) triggered sonodynamic therapy (SDT) has a wide application prospect in tumor therapy because of its deeper penetration depth. Herein, a novel MnSiO₃-Pt (MP) nanocomposite composed of MnSiO₃ nanosphere and noble metallic Pt was successfully constructed. After modification with bovine serum albumin (BSA) and chlorine e6 (Ce6), the multifunctional nanoplatform MnSiO₃-Pt@BSA-Ce6 (MPBC) realized the magnetic resonance imaging (MRI)-guided synergetic SDT/chemodynamic therapy (CDT). In this nanoplatform, sonosensitizer Ce6 can generate singlet oxygen (¹O₂) to kill cancer cells under US irradiation. Meanwhile, the loaded Pt has the ability to catalyze the decomposition of overexpressed hydrogen peroxide (H₂O₂) in tumor microenvironment (TME) to produce oxygen (O₂), which can conquer tumor hypoxia and promote the SDT-induced ¹O₂ production. In addition, MP can degrade in mildly acidic and reductive TME, causing the release of Mn²⁺. The released Mn²⁺ not only can be used for MRI, but also can generate hydroxyl radical (^∙OH) for CDT by Fenton-like reaction. The multifunctional nanoplatform MPBC has high biological safety and good anticancer effect, which displays the great latent capacity in biological application.
- Sonodynamic therapy,
- Chemodynamic therapy,
- Artificial enzyme,
- Oxygen generation,
- Synergetic therapy
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Tumor microenvironment-responsive MnSiO3-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy

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通讯作者: 陈斌, bchen63@163.com

Tumor microenvironment-responsive MnSiO₃-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy