Citation: Qin Zeng, Qingya Wei, Jiarong Luo, Yong Qian, Minghui Yang, Yingping Zou, Limin Lu. Novel photoelectrochemical immunosensor for MCF-7 cell detection based on n-p organic semiconductor heterojunction[J]. Chinese Chemical Letters, ;2022, 33(6): 2954-2958. doi: 10.1016/j.cclet.2021.12.090 shu

Novel photoelectrochemical immunosensor for MCF-7 cell detection based on n-p organic semiconductor heterojunction

Qin Zeng ^{a, b} ,
Qingya Wei ^a ,
Jiarong Luo ^a ,
Yong Qian ^c ,
Minghui Yang ^{a, *,} ,
Yingping Zou ^{a, *,} ,
Limin Lu ^{b, *,}

a.
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
b.
Institute of Functional Materials and Agricultural Applied Chemistry, College of Science, Jiangxi Agricultural University, Nanchang 330045, China
c.
Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China

yangminghui@csu.edu.cn

yingpingzou@csu.edu.cn

lulimin816@hotmail.com

Received Date: 29 September 2021
Revised Date: 25 December 2021
Accepted Date: 31 December 2021
Available Online: 7 January 2022

Figures(7)

In this work, we developed a novel photoelectrochemical (PEC) sensor based on n-p organic semiconductor heterojunction for sensitive detecting MCF-7 cancer cells. BTA-C4Ph and PM6 were designed as photoactive materials to form n-p heterojunction, which greatly enhanced the photoelectric conversion efficiency. Antibody-modified magnetic nanoparticles were utilized to capture and separate MCF-7 cells from samples. Detection of MCF-7 is ascribed to the loading of MCF-7 onto BTA-C4Ph-PM6 modified electrode that resulted in the decrease of photocurrent intensity. The PEC immunosensor displayed a linear concentration ranging from 50 cell/mL to 1 × 10⁴ cell/mL with a limit of detection (LOD) of 41 cell/mL (S/N = 3) for MCF-7. Additionally, the senor also exhibited good stability, excellent selectivity and prominent reproducibility. Furthermore, the sensor was successfully applied to detect MCF-7 in whole blood. This work illustrates that n-p heterojunction of organic semiconductor may find wide applications for the preparation of different photoelectrochemical sensors.
- Photoelectrochemical immunosensor,
- Organic semiconductors,
- n-p Heterojunction,
- MCF-7
1. [1]
  R.L. Siegel, K.D. Miller, H.E. Fuchs, CA Cancer. J. Clin.71 (2021) 7–33. doi: 10.3322/caac.21654
2. [2]
  D. Roder, N. Houssami, G. Farshid, et al., Breast Cancer. Res. Treat. 108 (2008) 409–416. doi: 10.1007/s10549-007-9609-5
3. [3]
  T.T. Zheng, Q.F. Zhang, S. Feng, et al., J. Am. Chem. Soc. 136 (2014) 2288–2291. doi: 10.1021/ja500169y
4. [4]
  M. Su, H. Liu, L. Ge, Electrochimica. Acta 146 (2014) 262–269. doi: 10.1016/j.electacta.2014.08.129
5. [5]
  X. Yan, Y.P. Song, J.M. Liu, et al., Biosens. Bioelectron. 126 (2019) 734–742. doi: 10.1016/j.bios.2018.11.047
6. [6]
  C.X. Gu, C.P. Guo, Z.Z. Li, et al., Biosens. Bioelectron. 134 (2019) 8–15. doi: 10.1016/j.bios.2019.03.043
7. [7]
  B. Yang, B.B. Chen, M. He, et al., Anal. Chem. 90 (2018) 2355–2361. doi: 10.1021/acs.analchem.7b04927
8. [8]
  Y. Li, Y.L. Zhang, M. Zhao, et al., Chem. Commun. 52 (2016) 3959–3961. doi: 10.1039/C6CC01014H
9. [9]
  Z.Q. Liang, Y.Q. Sun, R.H. Duan, et al., Anal. Chem. 93 (2021) 12434–12440. doi: 10.1021/acs.analchem.1c02591
10. [10]
  D. Wu, Z.H. Zhang, Chem. Commun. 55 (2019) 14514–14517. doi: 10.1039/c9cc08521a
11. [11]
  J. Wang, J. Long, Z.H. Liu, Biosens. Bioelectron. 91(2017) 53–59. doi: 10.21272/mmi.2017.3-05
12. [12]
  J.F. Chang, W.X. Lv, J.H. Wu, et al., Chin. Chem. Lett. 32 (2021) 775–778. doi: 10.1016/j.cclet.2020.05.041
13. [13]
  H. Dai, S. Zhang, Z. Hong, et al., Anal. Chem. 88 (2016) 9532–9538. doi: 10.1021/acs.analchem.6b02101
14. [14]
  D. Jiang, X. Du, L. Zhou, et al., Anal. Chem. 89 (2017) 4525–4531. doi: 10.1021/acs.analchem.6b04949
15. [15]
  G.L. Wang, J.J. Xu, H.Y. Chen, Sci. China. Chem. 52 (2009) 1789–1800. doi: 10.1007/s11426-009-0271-0
16. [16]
  N. Kodan, M. Ahmad, B.R. Mehta, Int. J. hydrogen. Energy. 46 (2021) 189–196. doi: 10.1016/j.ijhydene.2020.09.096
17. [17]
  K. Zou, Y.M. Fu, R.Y. Yang, et al., Anal. Chim. Acta 1099 (2020) 75–84. doi: 10.1016/j.aca.2019.11.054
18. [18]
  Q.W. Chen, C. Yuan, C.Y. Zhai, et al., Chin. Chem. Lett. 32 (2021) 775–778.
19. [19]
  D. Long, M. j. Li, H.H. Wang, et al., Anal. Chem. 92 (2020) 14769–14774. doi: 10.1021/acs.analchem.0c03497
20. [20]
  S.Y. Liang, S.Y. Li, Y.N. Zhang, et al., Adv. Funct. Mater. 31 (2021) 2102764. doi: 10.1002/adfm.202102764
21. [21]
  L.P. Duan, Y. Zhang, M.R. He, et al., ACS Appl. Mater. Interfaces 12 (2020) 27433–27442. doi: 10.1021/acsami.0c05978
22. [22]
  M.R. Ren, G.C. Zhang, Z. Chen, et al., ACS. Appl. Mater. Interfaces 12 (2020) 13077–13086. doi: 10.1021/acsami.9b23011
23. [23]
  L. Perdigón-Toro, H.T. Zhang, A. Markina, et al., Adv. Mater. 32 (2020) 1906763. doi: 10.1002/adma.201906763
24. [24]
  R. Wang, C.F. Zhang, Q. Li, et al., J. Am. Chem. Soc. 142 (2020) 12751–12759. doi: 10.1021/jacs.0c04890
25. [25]
  X.J. Li, R.J. Ma, T. Liu, et al., Sci. China. Chem. 63 (2020) 1256–1261. doi: 10.1007/s11426-020-9805-7
26. [26]
  Q.P. Fan, Y. Wang, M.J. Zhang, Adv. Mater. 30 (2018) 1704546. doi: 10.1002/adma.201704546
27. [27]
  Q. Guo, Q. Guo, Y.F. Geng, Mater. Chem. Front. 5 (2021) 3257–3280. doi: 10.1039/d1qm00060h
28. [28]
  J. Yuan, Y.Q. Zhang, L.Y. Zhou, et al., Joule 3 (2019) 1140–1151. doi: 10.1016/j.joule.2019.01.004
29. [29]
  R.N. Yu, G.Z. Wu, Z.A. Tan, J. Energy. Chem. 61 (2021) 29–46. doi: 10.1016/j.jechem.2021.01.027
30. [30]
  X.M. Zhao, L.Y. Zen, N. Hosmane, et al., Chin. Chem. Lett. 30 (2019) 87–89. doi: 10.1016/j.cclet.2018.01.028
31. [31]
  C.Y. Wen, L.L. Wu, Z.L. Zhang, et al., ACS. Nano. 8 (2014) 941–949. doi: 10.1021/nn405744f
32. [32]
  C.C. Shen, S.P. Liu, X.Q. Li, et al., Anal. Chem. 91 (2019) 11614–11619. doi: 10.1021/acs.analchem.9b01897
33. [33]
  J.J. Luo, D. Liang, D. Zhao, et al., Biosens. Bioelectron. 151 (2020) 111976. doi: 10.1016/j.bios.2019.111976
34. [34]
  S.X. Liu, B. Yu, S. Wang, et al., Adv. Colloid. Interface. 281 (2020) 102165. doi: 10.1016/j.cis.2020.102165
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2. [2]
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7. [7]
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