Citation: Chuan Guo, Jie Zhang, Xiaojun Feng, Zhenggui Du, Yuanzhang Jiang, Yidong Shi, Guanghui Yang, Lin Tan. Polyhexamethylene biguanide chemically modified cotton with desirable hemostatic, inflammation-reducing, intrinsic antibacterial property for infected wound healing[J]. Chinese Chemical Letters, ;2022, 33(6): 2975-2981. doi: 10.1016/j.cclet.2021.12.086 shu

Polyhexamethylene biguanide chemically modified cotton with desirable hemostatic, inflammation-reducing, intrinsic antibacterial property for infected wound healing

Chuan Guo ^a ,
Jie Zhang ^a ,
Xiaojun Feng ^b ,
Zhenggui Du ^{b, *,} ,
Yuanzhang Jiang ^a ,
Yidong Shi ^a ,
Guanghui Yang ^c ,
Lin Tan ^{a, d, *,}

a.
College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China
b.
Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
c.
School of Materials and Environmental Engineering, Shenzhen Polytechnic, Shenzhen 518000, China
d.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

docduzg@163.com

tanlinou@scu.edu.cn

Received Date: 10 October 2021
Revised Date: 20 December 2021
Accepted Date: 31 December 2021
Available Online: 7 January 2022

Figures(7)

Medical cotton dressing is cheap and widely used in diversified fields, but in the application of promoting wound healing, the continuous research of multifunctional medical cotton dressing is still of great significance. Here, we developed a fresh type of antibacterial cotton dressing through a succinct strategy based on chemically anchoring polyhexamethylene biguanide (PHMB). Intriguingly, after PHMB modification, the cotton dressing exhibited outstanding antibacterial performance which could maintain > 99.99% antibacterial rate after several treatments, including washing 50 times, repeated use 10 times, UV irradiation for 7 days, cationic dyes dying, and conditioned under 90 ℃ water bath for 2 h. In addition, the water contact angle of cotton dressing increased dramatically from 0° to 111°, which could facilitate bacterial adhesion, thus further enhance the antibacterial efficiency, and easily remove the bacterial debris. Apart from that, the developed cotton dressing showed good cytocompatibility, promoted blood clotting and expression of platelets, and promoted the wound healing process in the infection intervened skin wound model. Taken together, this antibacterial cotton dressing with desirable blood clotting, sustained protection against bacterial infection and bacterial removal features shows the potential to be a candidate for infected skin wound healing.
- Cotton dressing,
- Polyhexamethylene biguanidine,
- Antibacterial performance,
- Blood clotting,
- Infected wound healing
1. [1]
  T. Kobayashi, S. Naik, K. Nagao, Immunity 50 (2019) 552-565. doi: 10.1016/j.immuni.2019.02.023
2. [2]
  J.Q. Coentro, E. Pugliese, G. Hanley, M. Raghunath, D.I. Zeugolis, Adv. Drug. Deliv. Rev. 146 (2019) 37-59. doi: 10.1016/j.addr.2018.08.009
3. [3]
  R. Jamaledin, C.K.Y. Yiu, E.N. Zare, et al., Adv. Mater. 32 (2020) e2002129. doi: 10.1002/adma.202002129
4. [4]
  H. Cui, M. Liu, W. Yu, et al., ACS Appl. Mater. Interfaces 13 (2021) 26800-26807. doi: 10.1021/acsami.1c07409
5. [5]
  R.M. Donlan, J.W. Costerton, Clin. Microbiol. Rev. 15 (2002) 167-193. doi: 10.1128/CMR.15.2.167-193.2002
6. [6]
  J. He, Y. Qiao, H. Zhang, et al., Biomaterials 234 (2020) 119763. doi: 10.1016/j.biomaterials.2020.119763
7. [7]
  Z. Luo, L. Jiang, C. Xu, et al., Chem. Eng. J. 421 (2021) 127725. doi: 10.1016/j.cej.2020.127725
8. [8]
  J. Yan, Y. Ji, M. Huang, et al., ACS Mater. Lett. 2 (2020) 1375-1380. doi: 10.1021/acsmaterialslett.0c00304
9. [9]
  M. Li, Z. Zhang, Y. Liang, J. He, B. Guo, ACS Appl. Mater. Interfaces 12 (2020) 35856-35872. doi: 10.1021/acsami.0c08285
10. [10]
  K. Zhang, X. Bai, Z. Yuan, et al., Biomaterials 204 (2019) 70-79. doi: 10.1016/j.biomaterials.2019.03.008
11. [11]
  J. Xiang, R. Zhu, S. Lang, et al., Chem. Eng. J. 409 (2021) 128291. doi: 10.1016/j.cej.2020.128291
12. [12]
  C. Jiayu, Am. J. Nurs. 9 (2020) 2328-5753.
13. [13]
  B. Mirani, E. Pagan, B. Currie, et al., Adv. Healthc. Mater. 6 (2017) 19.
14. [14]
  F. Gao, T. Shao, Y. Yu, et al., Nat. Commun. 12 (2021) 745. doi: 10.1038/s41467-021-20965-3
15. [15]
  B.R. Rao, R. Kumar, S. Haque, et al., ACS Appl. Mater. Interfaces 13 (2021) 10689-10704. doi: 10.1021/acsami.0c19904
16. [16]
  W.Y. Wang, J.C. Chiou, J. Yip, K.F. Yung, C.W. Kan, Coatings 10 (2020) 520. doi: 10.3390/coatings10060520
17. [17]
  J. Jin, Z.L. Chen, Y. Xiang, et al., Wound Repair Regen. 28 (2020) 480-492. doi: 10.1111/wrr.12813
18. [18]
  Y. Li, J. Li, Z. Shi, et al., Carbohydr. Polym. 243 (2020) 116470. doi: 10.1016/j.carbpol.2020.116470
19. [19]
  J. Zhang, H. Luo, X. Yin, et al., Surf. Coat. Technol. 422 (2021) 127521. doi: 10.1016/j.surfcoat.2021.127521
20. [20]
  I.S. Ng, C.W. Ooi, B.L. Liu, et al., Int. J. Biol. Macromol. 154 (2020) 844-854. doi: 10.1016/j.ijbiomac.2020.03.127
21. [21]
  M. Lavorante, J. Franco, J. Electrochem. Sci. Technol. 15 (2017) 342-350.
22. [22]
  J. Jiang, H. Oguzlu, F. Jiang, Chem. Eng. J. 405 (2021) 126668. doi: 10.1016/j.cej.2020.126668
23. [23]
  E. Llorens, S. Calderon, L.J. del Valle, J. Puiggali, Mater. Sci. Eng. C: Mater. Biol. Appl. 50 (2015) 74-84. doi: 10.1016/j.msec.2015.01.100
24. [24]
  J. Peng, P. Liu, W. Peng, et al., J. Hazard. Mater. 411 (2021) 125110. doi: 10.1016/j.jhazmat.2021.125110
25. [25]
  X. Yin, Y. Wen, Y. Li, et al., Front. Chem. 6 (2018) 490. doi: 10.3389/fchem.2018.00490
26. [26]
  X.Q. Dou, D. Zhang, C. Feng, L. Jiang, ACS Nano 9 (2015) 10664-10672. doi: 10.1021/acsnano.5b04231
27. [27]
  P.J. Weldrick, S. Iveson, M.J. Hardman, V.N. Paunov, Nanoscale 11 (2019) 10472-10485. doi: 10.1039/c8nr10022e
28. [28]
  L. Shi, W. Zhang, K. Yang, et al., J. Mater. Chem. B. 3 (2015) 733-737. doi: 10.1039/C4TB01924E
29. [29]
  H. Luo, X.Q. Yin, P.F. Tan, et al., J. Mater. Chem. B. 9 (2021) 2802-2815. doi: 10.1039/d1tb00109d
30. [30]
  T. Hemamalini, N. Vikash, P. Brindha, M. Abinaya, V.R.G. Dev, Int. J. Biol. Macromol. 147 (2020) 493-498. doi: 10.1016/j.ijbiomac.2020.01.085
31. [31]
  B. Wu, F. Du, A. Wenjing, G. Li, X. Wang, Chin. Chem. Lett. 33 (2022) 703–713. doi: 10.1016/j.cclet.2021.06.029
32. [32]
  X. Song, H. Ji, Y. Li, et al., Nat. Biomed. Eng. 5 (2021) 1143–1156. doi: 10.1038/s41551-020-00673-x
33. [33]
  C. Zheng, Q. Zeng, S. Pimpi, et al., J. Mater. Chem. B8 (2020) 5395-5410. doi: 10.1039/d0tb00906g
34. [34]
  M. Li, Y. Liang, J. He, H. Zhang, B. Guo, Chem. Mater. 32 (2020) 9937-9953. doi: 10.1021/acs.chemmater.0c02823
35. [35]
  X. Chen, P. Tan, Y. Wen, et al., Chin. Chem. Lett. 31 (2020) 1499-1503. doi: 10.1016/j.cclet.2019.11.006
36. [36]
  G. Liu, Z. Bao, J. Wu, Chin. Chem. Lett. 31 (2020) 1817-1821. doi: 10.1016/j.cclet.2020.03.005
37. [37]
  C. Xian, Z. Gu, G. Liu, J. Wu, Chin. Chem. Lett. 31 (2020) 1612-1615. doi: 10.1016/j.cclet.2019.09.011
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2. [2]
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6. [6]
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沈阳化工大学材料科学与工程学院沈阳 110142