Citation: Yongchao Song, Dongdong Wang, Zehua Li, Lirong Wang, Chuan Fan, Xuecheng He, Tailin Xu, Xueji Zhang. Jigsaw-like mini-pillar platform for multi-mode biosensing[J]. Chinese Chemical Letters, ;2022, 33(8): 3879-3882. doi: 10.1016/j.cclet.2021.12.059 shu

Jigsaw-like mini-pillar platform for multi-mode biosensing

Yongchao Song ^{b, c} ,
Dongdong Wang ^{a, b, *,} ,
Zehua Li ^b ,
Lirong Wang ^{b, c} ,
Chuan Fan ^{b, c} ,
Xuecheng He ^{b, c} ,
Tailin Xu ^{b, c, *,} ,
Xueji Zhang ^{b, c}

a.
College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China
b.
Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China
c.
School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China

wdd@btbu.edu.cn

xutailin@szu.edu.cn

Received Date: 7 August 2021
Revised Date: 15 October 2021
Accepted Date: 22 December 2021
Available Online: 27 December 2021

Figures(4)

The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets. Here, we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode (electrochemical, fluorescence, surface-enhanced Raman scattering (SERS) and colorimetric) sensing in individual microdroplets. Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing, and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals. We successfully implemented electrochemical, fluorescence, SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis. Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring.
- Multiple sensing,
- Jigsaw-like,
- Mini-pillar platform,
- Signal coupling,
- Microdroplets array
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