Citation: Ling Ding, Kaikai Niu, Yuxiu Liu, Qingmin Wang. Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones[J]. Chinese Chemical Letters, ;2022, 33(8): 4057-4060. doi: 10.1016/j.cclet.2021.12.053 shu

Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China

wangqm@nankai.edu.cn

Received Date: 12 October 2021
Revised Date: 17 December 2021
Accepted Date: 22 December 2021
Available Online: 26 December 2021

Figures(8)

Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.
- Electro-reductive,
- C-H cyanoalkylation,
- Reductant-free,
- Quinoxalin-2(1H)-ones,
- Ring-opening
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