Citation: Wang Li, Xiaoyue Zhang, Siqi Chen, Yibing Ji, Ruijun Li. Paper-based fluorescent devices for multifunctional assays: Biomarkers detection, inhibitors screening and chiral recognition[J]. Chinese Chemical Letters, ;2022, 33(9): 4405-4410. doi: 10.1016/j.cclet.2021.12.026 shu

Paper-based fluorescent devices for multifunctional assays: Biomarkers detection, inhibitors screening and chiral recognition

Wang Li ^{a, b} ,
Xiaoyue Zhang ^{a, b} ,
Siqi Chen ^{a, b} ,
Yibing Ji ^{a, b, *,} ,
Ruijun Li ^{a, b, *,}

a.
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China
b.
Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing 210009, China

jiyibing@msn.com

ccjlrj@cpu.edu.cn

Received Date: 23 August 2021
Revised Date: 7 October 2021
Accepted Date: 11 December 2021
Available Online: 17 December 2021

Figures(4)

The development of a single analytical platform with different functions is highly desirable but remains a challenge at present. Here, a paper-based device based on fluorescent carbon dots (CDs) functionalized paper/MnO₂ nanosheets (MnO₂ NS) hybrid devices (PCD/NS) was proposed for single-device multi-function applications. MnO₂ NS functioned as a fluorescence quencher of CDs and recognizer of H₂O₂ released from the oxidase catalyzed system. Fluorescence recovery would occur after the decomposition of MnO₂ NS induced by H₂O₂, by which a simple and effective strategy could be developed for fluorescence monitoring multiplex biological events. Xanthine (XA) sensing, xanthine oxidase (XOD) inhibitors screening analysis and chiral recognition of glucose enantiomers were performed on PCD/NS to investigate the multifunctional application of the paper-based device. By means of PCD/NS, XA could be determined in the range of 0.1–40 µmol/L with a low detection of limit of 0.06 µmol/L. The IC₅₀ value of allopurinol, the model inhibitor of XOD, was sensitively detected to be 7.4 µmol/L. Glucose enantiomers were also recognized in terms of the specific fluorescence response to d-glucose. This work firstly presented a paper-based device capable of biomarkers detection, inhibitors screening and chiral recognition, which enlightened a promising strategy for the construction of multifunctional devices and hold the great potential application in clinical diagnosis and drug discovery.
- Paper-based devices,
- Multifunctional,
- Xanthine,
- Inhibitor screening,
- Chiral recognition
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沈阳化工大学材料科学与工程学院沈阳 110142