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Citation: Peng-Jun Zhou, Yi Zang, Cong Li, Lin Yuan, Huaqiang Zeng, Jia Li, Jin-Feng Hu, Juan Xiong. Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii[J]. Chinese Chemical Letters, ;2022, 33(9): 4264-4268. doi: 10.1016/j.cclet.2021.12.009 shu

Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii

Peng-Jun Zhou ^{a, b} ,
Yi Zang ^c ,
Cong Li ^c ,
Lin Yuan ^d ,
Huaqiang Zeng ^e ,
Jia Li ^c ,
Jin-Feng Hu ^{a, b, *,} ,
Juan Xiong ^{a, *,}

a.
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China
b.
School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Taizhou 318000, China
c.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
d.
College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China
e.
Frontier Research Center for Multidisciplinary Sciences, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China

jxiong@fudan.edu.cn

jfhu@tzc.edu.cn

jfhu@fudan.edu.cn

Received Date: 23 September 2021
Revised Date: 20 November 2021
Accepted Date: 6 December 2021
Available Online: 9 December 2021

Figures(5)

Forrestiacids C (1) and D (2), a pair of C-25 epimeric triterpene–diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii. This unprecedented class of compounds might be generated via an intermolecular Michael addition reaction of a rearranged 6/6/5/5-fused spiro-lanostene with an abietene. Their structures were established by spectroscopic data and X-ray crystallography. The adducts showed inhibitory activities against the ATP-citrate lyase (ACL) and acetyl-CoA carboxylase 1 (ACC1), two rate-limiting enzymes in the de novo lipogenesis pathway.
- Forrestiacid,
- Pseudotsuga forrestii,
- Pinaceae,
- Michael adduct,
- Lipogenesis inhibitor
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