Citation: Yao Chai, Longming Chen, Yahan Zhang, Liang Zhao, Zhao Meng, Junyi Chen, Chunju Li, Qingbin Meng. Reversing neuromuscular blocking agent decamethonium by carboxylatopillar[6]arene based on host-guest encapsulation[J]. Chinese Chemical Letters, ;2022, 33(6): 3003-3006. doi: 10.1016/j.cclet.2021.11.087 shu

Reversing neuromuscular blocking agent decamethonium by carboxylatopillar[6]arene based on host-guest encapsulation

Yao Chai ^{a, 1} ,
Longming Chen ^{a, 1} ,
Yahan Zhang ^a ,
Liang Zhao ^a ,
Zhao Meng ^a ,
Junyi Chen ^{a, b, *,} ,
Chunju Li ^{b, *,} ,
Qingbin Meng ^{a, c, *,}

a.
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
b.
Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
c.
Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China

^**

jychen@tjnu.edu.cn

cjli@shu.edu.cn

naikaimqb@sina.com

Received Date: 5 October 2021
Revised Date: 25 November 2021
Accepted Date: 29 November 2021
Available Online: 3 December 2021

Figures(4)

Neuromuscular blocking agents (NMBAs) are extensively used during anesthesia to improve surgical conditions by relaxing skeletal muscle movements. Rapid neuromuscular recovery after surgery is desirable to facilitate the recovery of muscle function and prevent residual blockade. Decamethonium (C10) is a classic NMBA, which has been restricted over the past decades ascribed to lack of a suitable antidote in clinic. Herein we used carboxylatopillar[6]arene (CP6A) to reverse neuromuscular blocker effect of C10 through direct host-guest encapsulation. NMR and isothermal titration calorimetry served to confirm the complexation between CP6A and C10 with robust affinity [(1.07 ± 0.14) × 10⁷ L/mol]. The CP6A was further used as a reversal agent of C10, which facilitated to decrease C10 concentration in mice blood and excrete via urinary clearance, resulting in rapid recovery from muscle relaxation. These favorable outcomes might lead us to suggest that this supramolecular strategy could allow patients to regain lucidity much faster than spontaneous recovery from anesthesia.
- Host-guest encapsulation,
- Decamethonium,
- Neuromuscular blocking agents,
- Supramolecular strategy,
- Carboxylatopillar[6]arene
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