Citation: Zhengwen Fang, Xinyu Zhang, Hai Huang, Jun Wu. Exosome based miRNA delivery strategy for disease treatment[J]. Chinese Chemical Letters, ;2022, 33(4): 1693-1704. doi: 10.1016/j.cclet.2021.11.050 shu

Exosome based miRNA delivery strategy for disease treatment

Zhengwen Fang ^{a, 1} ,
Xinyu Zhang ^{b, 1} ,
Hai Huang ^{c, *,} ,
Jun Wu ^{a, *,}

a.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
b.
Department of Drug Clinical Trial Institution, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hosptial, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China
c.
Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510220, China

huanghai257@126.com

wujun29@mail.sysu.edu.cn

Received Date: 6 July 2021
Revised Date: 11 November 2021
Accepted Date: 15 November 2021
Available Online: 19 November 2021

Figures(10)

miRNA, which is a common non-coding RNA, can target various mRNAs to regulate their physiological activities. Therefore, miRNAs play an important role in various physiological and pathological processes, and so they have been proposed as a powerful tool to treat different diseases efficiently. However, the characteristic of miRNA degradation in vivo limits its further clinical application. Exosomes have the advantage of crossing the biological barrier and achieving long-distance communication with cells, so they are excellent vectors for miRNAs. By studying the biogenesis of exosomes, the way for loading miRNAs, the mechanism of targeting, and disease occurrence and development, it is confirmed that exosomes can enrich specific endogenous miRNAs and regulate a variety of physiological activities, such as promoting cancer cell apoptosis, regulating lipid metabolism and promoting angiogenesis. It is shown that exosomes loaded with miRNAs have good performance in the fields of cancer, neurodegenerative diseases, cardiovascular disease treatment, and regenerative medicine. In this paper, the application and research progress of exosomes carrying miRNA in the above fields are systematically described.
- Mirna,
- Extracellular vesicles,
- Drug carrier,
- Cancer therapy
1. [1]
  S. Paul, L.A. Bravo Vazquez, S. Perez Uribe, et al., Cells 9 (2020) 1698. doi: 10.3390/cells9071698
2. [2]
  Y. Xu, L. Shen, F. Li, et al., J. Cell Physiol. 234 (2019) 21380–21394. doi: 10.1002/jcp.28747
3. [3]
  P. Sharma, I. Dando, R. Strippoli, et al., Front. Pharmacol. 11 (2020) 1141. doi: 10.3389/fphar.2020.01141
4. [4]
  C. Chakraborty, A.R. Sharma, G. Sharma, et al., J. Adv. Res. 28 (2021) 127–138. doi: 10.1016/j.jare.2020.08.012
5. [5]
  Q. Bi, X. Song, A. Hu, et al., Chin. Chem. Lett. 31 (2020) 3041–3046. doi: 10.1016/j.cclet.2020.07.030
6. [6]
  S. Raj, S. Khurana, R. Choudhari, et al., Semin. Cancer Biol. 69 (2021) 166–177. doi: 10.1016/j.semcancer.2019.11.002
7. [7]
  F. Abedi-Gaballu, G. Dehghan, M. Ghaffari, et al., Appl. Mater. Today 12 (2018) 177–190. doi: 10.1016/j.apmt.2018.05.002
8. [8]
  H. Zhang, X. You, X. Wang, et al., PNAS 118 (2021) e2005191118. doi: 10.1073/pnas.2005191118
9. [9]
  C. Xian, Q. Yuan, Z. Bao, et al., Chin. Chem. Lett. 31 (2020) 19–27. doi: 10.1016/j.cclet.2019.03.052
10. [10]
  Q. Xiong, G.Y. Lee, J. Ding, et al., Nano Res. 11 (2018) 5281–5309. doi: 10.1007/s12274-018-2146-1
11. [11]
  Y. Liu, D. Li, J. Ding, et al., Chin. Chem. Lett. 31 (2020) 3001–3014. doi: 10.1016/j.cclet.2020.04.029
12. [12]
  M.M. Lino, S. Simoes, A. Vilaca, et al., ACS Nano 12 (2018) 5207–5220. doi: 10.1021/acsnano.7b07538
13. [13]
  T. Kang, J.S. Ni, T. Li, et al., Biomaterials 275 (2021) 120907. doi: 10.1016/j.biomaterials.2021.120907
14. [14]
  H. Zhao, T. Li, C. Yao, et al., ACS Appl. Mater. Interfaces 13 (2021) 6034–6042. doi: 10.1021/acsami.0c21006
15. [15]
  C. Zheng, M. Li, J. Ding, BIO Integration 2 (2021) 57–60. doi: 10.15212/bioi-2021-0016
16. [16]
  L. Wei, J. Chen, J. Ding, Nanomedicine 16 (2021) 261–264. doi: 10.2217/nnm-2021-0019
17. [17]
  J. Huang, X. You, P. Xin, et al., Chin. Chem. Lett. 32 (2021) 1737–1742. doi: 10.1016/j.cclet.2020.12.006
18. [18]
  Y. Mao, C. Zou, Y. Jiang, et al., Chin. Chem. Lett. 32 (2021) 990–998. doi: 10.1016/j.cclet.2020.08.048
19. [19]
  B. Zhou, K. Xu, X. Zheng, et al., Signal Transduct. Target. Ther. 5 (2020) 144. doi: 10.1038/s41392-020-00258-9
20. [20]
  K. Jiang, Y. Wu, J. Chen, et al., Chin. Chem. Lett. 32 (2021) 1827–1830. doi: 10.1016/j.cclet.2020.11.031
21. [21]
  X. Xia, Y. Wang, Y. Huang, et al., Prog. Neurobiol. 183 (2019) 101694. doi: 10.1016/j.pneurobio.2019.101694
22. [22]
  J. Cheng, J. Meng, L. Zhu, et al., Mol. Cancer. 19 (2020) 66. doi: 10.1186/s12943-020-01189-3
23. [23]
  B. Sun, Y. Ma, F. Wang, et al., Stem Cell Res. Ther. 10 (2019) 360. doi: 10.1186/s13287-019-1442-3
24. [24]
  M. Wei, X. Gao, L. Liu, et al., ACS Nano 14 (2020) 5099–5110. doi: 10.1021/acsnano.0c01860
25. [25]
  C.L. Deng, C.B. Hu, S.T. Ling, et al., Cell Death Differ. 28 (2020) 1041.
26. [26]
  R. Kalluri, V.S. LeBleu, Science 367 (2020) eaau6977. doi: 10.1126/science.aau6977
27. [27]
  D. Wei, W. Zhan, Y. Gao, et al., Cell Res. 31 (2020) 157.
28. [28]
  J.M. Gudbergsson, K. Jønsson, J.B. Simonsen, et al., J. Control. Release 306 (2019) 108–120. doi: 10.1016/j.jconrel.2019.06.006
29. [29]
  J. Dai, Y. Su, S. Zhong, et al., Signal Transduct. Tar, 5 (2020) 145. doi: 10.1038/s41392-020-00261-0
30. [30]
  H. Wang, Z. Lu, X. Zhao, J. Hematol. Oncol. 12 (2019) 133. doi: 10.1186/s13045-019-0806-6
31. [31]
  F. Xie, X. Zhou, M. Fang, et al., Adv. Sci. 6 (2019) 1901779. doi: 10.1002/advs.201901779
32. [32]
  M. Ostrowski, N.B. Carmo, S. Krumeich, et al., Nat. Cell Biol. 12 (2010) 19–30. doi: 10.1038/ncb2000
33. [33]
  P. Wu, B. Zhang, D.K.W. Ocansey, et al., Biomaterials 269 (2020) 120467.
34. [34]
  Y.T. Kang, T. Hadlock, T.W. Lo, et al., Adv. Sci. (Weinh) 7 (2020) 2001581. doi: 10.1002/advs.202001581
35. [35]
  L. Yang, D. Han, Q. Zhan, et al., Theranostics 9 (2019) 7680–7696. doi: 10.7150/thno.37220
36. [36]
  H. Shao, H. Im, C.M. Castro, et al., Chem. Rev. 118 (2018) 1917–1950. doi: 10.1021/acs.chemrev.7b00534
37. [37]
  J. Wang, D. Chen, E.A. Ho, J. Control. Release 329 (2020) 894–906. doi: 10.3390/agronomy10060894
38. [38]
  M. Wu, Y. Ouyang, Z. Wang, et al., PNAS 114 (2017) 10584–10589. doi: 10.1073/pnas.1709210114
39. [39]
  X. Li, C. Li, L. Zhang, et al., Mol. Cancer 19 (2020) 1. doi: 10.1186/s12943-019-1085-0
40. [40]
  M. Katakowski, B. Buller, X. Zheng, et al., Cancer Lett. 335 (2013) 201–204. doi: 10.1016/j.canlet.2013.02.019
41. [41]
  X. Yu, M. Odenthal, J.W. Fries, Int. J. Mol. Sci 17 (2016) 2028. doi: 10.3390/ijms17122028
42. [42]
  C. Villarroya-Beltri, C. Gutierrez-Vazquez, F. Sanchez-Cabo, et al., Nat. Commun. 4 (2013) 2980. doi: 10.1038/ncomms3980
43. [43]
  Z. Li, X. Zhou, M. Wei, et al., Nano Lett. 19 (2019) 19–28. doi: 10.1021/acs.nanolett.8b02689
44. [44]
  D.S. Sutaria, J. Jiang, O.A. Elgamal, et al., J. Extracell. Vesicles 6 (2017) 1333882. doi: 10.1080/20013078.2017.1333882
45. [45]
  G. Liang, Y. Zhu, D.J. Ali, et al., J. Nanobiotechnology 18 (2020) 10. doi: 10.1186/s12951-019-0563-2
46. [46]
  M. Piffoux, A. Nicolas-Boluda, V. Mulens-Arias, et al., Adv. Drug Deliv. Rev. 138 (2019) 247–258. doi: 10.1016/j.addr.2018.12.009
47. [47]
  G. Won Lee, M. Thangavelu, M. Joung Choi, et al., J. Cell Biochem. 121 (2020) 3642–3652. doi: 10.1002/jcb.29657
48. [48]
  K. Bryniarski, W. Ptak, A. Jayakumar, et al., J. Allergy Clin. Immunol. 132 (2013) 170–181. doi: 10.1016/j.jaci.2013.04.048
49. [49]
  A. Jeyaram, T.N. Lamichhane, S. Wang, et al., Mol. Ther. 28 (2020) 975–985. doi: 10.1016/j.ymthe.2019.12.007
50. [50]
  O.M. Elsharkasy, J.Z. Nordin, D.W. Hagey, et al., Adv. Drug Deliv. Rev. 159 (2020) 332–343. doi: 10.1016/j.addr.2020.04.004
51. [51]
  Z. Li, J. Huang, J. Wu, Biomater Sci. 9 (2021) 574–589. doi: 10.1039/d0bm01729a
52. [52]
  Q. Xu, L. Wang, T. Tong, et al., Appl. Mater. Today 21 (2020) 100849. doi: 10.1016/j.apmt.2020.100849
53. [53]
  K. Ou, Y. Kang, L. Chen, et al., Biomater Sci. 7 (2019) 2491–2498. doi: 10.1039/c9bm00344d
54. [54]
  N. Perets, O. Betzer, R. Shapira, et al., Nano Lett. 19 (2019) 3422–3431. doi: 10.1021/acs.nanolett.8b04148
55. [55]
  R. He, Y. Jiang, Y. Shi, et al., Mater. Sci. Eng. C Mater. Biol. Appl. 117 (2020) 111314. doi: 10.1016/j.msec.2020.111314
56. [56]
  T.J. Antes, R.C. Middleton, K.M. Luther, et al., J. Nanobiotechnology 16 (2018) 61. doi: 10.1186/s12951-018-0388-4
57. [57]
  F. Yan, Z. Zhong, Y. Wang, et al., J. Nanobiotechnology 18 (2020) 115. doi: 10.1186/s12951-020-00675-6
58. [58]
  F. Royo, U. Cossio, A. Ruiz de Angulo, et al., Nanoscale 11 (2019) 1531–1537. doi: 10.1039/c8nr03900c
59. [59]
  M. Luo, X. Zhang, J. Wu, et al., Carbohydr. Polym. 266 (2021) 118097. doi: 10.1016/j.carbpol.2021.118097
60. [60]
  R. Tamura, S. Uemoto, Y. Tabata, Acta. Biomater. 57 (2017) 274–284. doi: 10.1016/j.actbio.2017.05.013
61. [61]
  J. Huang, Y. Li, A. Orza, et al., Adv. Funct. Mater. 26 (2016) 3818–3836. doi: 10.1002/adfm.201504185
62. [62]
  X. Li, Y. Wang, L. Shi, et al., J. Nanobiotechnology 18 (2020) 113. doi: 10.1186/s12951-020-00670-x
63. [63]
  S. Liu, X. Chen, L. Bao, et al., Nat. Biomed. Eng. 4 (2020) 1063–1075. doi: 10.1038/s41551-020-00637-1
64. [64]
  J. Wang, W. Li, L. Zhang, et al., ACS Appl. Mater. Interfaces 9 (2017) 27441–27452. doi: 10.1021/acsami.7b06464
65. [65]
  X. Wang, Y. Chen, Z. Zhao, et al., J. Am. Heart Assoc. 7 (2018) e008737. doi: 10.1161/JAHA.118.008737
66. [66]
  L. Alvarez-Erviti, Y. Seow, H. Yin, et al., Nat. Biotechnol. 29 (2011) 341–345. doi: 10.1038/nbt.1807
67. [67]
  S. Ohno, M. Takanashi, K. Sudo, et al., Mol. Ther. 21 (2013) 185–191. doi: 10.1038/mt.2012.180
68. [68]
  K.B. Johnsen, J.M. Gudbergsson, M.N. Skov, et al., Biochim. Biophys. Acta 1846 (2014) 75–87.
69. [69]
  M. Grapp, A. Wrede, M. Schweizer, et al., Nat. Commun. 4 (2013) 2123. doi: 10.1038/ncomms3123
70. [70]
  T. Yong, D. Wang, X. Li, et al., J. Control. Release 322 (2020) 555–565. doi: 10.1016/j.jconrel.2020.03.039
71. [71]
  A. Mullard, Nat. Biotechnol. 38 (2020) 1221–1223. doi: 10.1038/s41587-020-0724-8
72. [72]
  X. Xu, C. Liu, Y. Wang, et al., Adv. Drug Deliv. Rev. (2021) 113891.
73. [73]
  M.A. Islam, J. Rice, E. Reesor, et al., Biomaterials 266 (2021) 120431. doi: 10.1016/j.biomaterials.2020.120431
74. [74]
  G.H. Nam, Y. Choi, G.B. Kim, et al., Adv. Mater. 32 (2020) e2002440. doi: 10.1002/adma.202002440
75. [75]
  T. Huang, C. Song, L. Zheng, et al., Mol. Cancer 18 (2019) 62.
76. [76]
  J. Xie, Y. Lu, B. Yu, et al., Chin. Chem. Lett. 31 (2020) 1173–1177. doi: 10.1016/j.cclet.2019.10.030
77. [77]
  H. Xie, K. Di, R. Huang, et al., Chin. Chem. Lett. 31 (2020) 1737–1745. doi: 10.1016/j.cclet.2020.02.049
78. [78]
  J. Zhang, M. Hou, G. Chen, et al., Chin. Chem. Lett. 32 (2021) 3474–3478. doi: 10.1016/j.cclet.2021.04.056
79. [79]
  A. Bronisz, Y. Wang, M.O. Nowicki, et al., Cancer Res. 74 (2014) 738–750. doi: 10.1158/0008-5472.CAN-13-2650
80. [80]
  X. Zhang, X. Zhang, S. Hu, et al., Nucleic Acids Res. 45 (2017) 5930–5944. doi: 10.1093/nar/gkx317
81. [81]
  M. Fareh, F. Almairac, L. Turchi, et al., Cell Death Dis. 8 (2017) e2713. doi: 10.1038/cddis.2017.117
82. [82]
  F.M. Lang, A. Hossain, J. Gumin, et al., Neuro. Oncol. 20 (2018) 380–390. doi: 10.1093/neuonc/nox152
83. [83]
  S.G. Lei Yu, Yawei Liu, Xiaoyu Qiu, et al., Aging-US 11 (2019) 5300–5318. doi: 10.18632/aging.102092
84. [84]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA Cancer J. Clin. 71 (2021) 209. doi: 10.3322/caac.21660
85. [85]
  S. Mohammadi-Yeganeh, V. Hosseini, M. Paryan, J. Cell Physiol. 234 (2019) 18317–18328. doi: 10.1002/jcp.28465
86. [86]
  Y. Yu, W. Luo, Z.J. Yang, et al., Mol. Cancer 17 (2018) 70. doi: 10.1109/imcec.2018.8469488
87. [87]
  Y. Gao, X. Li, C. Zeng, et al., Adv. Sci. (Weinh) 7 (2020) 2002518. doi: 10.1002/advs.202002518
88. [88]
  M. Han, J. Hu, P. Lu, et al., Cell Death Dis. 11 (2020) 43. doi: 10.1007/s43236-019-00013-6
89. [89]
  S. Shojaei, S.M. Hashemi, H. Ghanbarian, et al., Stem Cell Rev. Rep. 17 (2021) 1027–1038. doi: 10.1007/s12015-020-10089-4
90. [90]
  E.J. Park, H.J. Jung, H.J. Choi, et al., FASEB J. 34 (2020) 3379–3398. doi: 10.1096/fj.201902434r
91. [91]
  M. Moradi-Chaleshtori, M. Bandehpour, S. Soudi, et al., Cancer Immunol. Immunother. 70 (2020) 1341.
92. [92]
  H. Wu, X. Mu, L. Liu, et al., Cell Death Dis. 11 (2020) 801. doi: 10.1049/iet-cta.2019.1172
93. [93]
  H. Zhang, J. Wang, T. Ren, et al., Cancer Lett. 490 (2020) 54–65. doi: 10.1016/j.canlet.2020.07.008
94. [94]
  Y. Jia, X. Ding, L. Zhou, et al., Oncogene. 40 (2020) 246.
95. [95]
  Z. He, W. Li, T. Zheng, et al., J. Exp. Clin. Cancer Res. 39 (2020) 140. doi: 10.1186/s13046-020-01631-w
96. [96]
  Z. Chen, Y. Xie, W. Chen, et al., Life Sci. 284 (2021) 119222. doi: 10.1016/j.lfs.2021.119222
97. [97]
  M. Kobayashi, K. Sawada, M. Miyamoto, et al., Biochem. Biophys. Res. Commun. 527 (2020) 153–161. doi: 10.1016/j.bbrc.2020.04.076
98. [98]
  X. Zhang, J. Bai, H. Yin, et al., Mol. Oncol. 14 (2020) 2589–2608. doi: 10.1002/1878-0261.12765
99. [99]
  M.S. Phipps, C.A. Cronin, BMJ 368 (2020) l6983. doi: 10.1136/bmj.l6983
100. [100]
  H. Xin, Y. Li, Z. Liu, et al., Stem Cells 31 (2013) 2737–2746. doi: 10.1002/stem.1409
101. [101]
  G.J. Moon, J.H. Sung, D.H. Kim, et al., Transl. Stroke Res. 10 (2019) 509–521. doi: 10.1007/s12975-018-0668-1
102. [102]
  S. Huang, X. Ge, J. Yu, et al., FASEB J. 32 (2018) 512–528. doi: 10.1096/fj.201700673r
103. [103]
  Y. Song, Z. Li, T. He, et al., Theranostics 9 (2019) 2910–2923. doi: 10.7150/thno.30879
104. [104]
  J. Yang, L.L. Cao, X.P. Wang, et al., Cell Death Dis. 12 (2021) 23. doi: 10.1038/s41419-020-03310-2
105. [105]
  H. Xin, M. Katakowski, F. Wang, et al., Stroke 48 (2017) 747–753. doi: 10.1161/STROKEAHA.116.015204
106. [106]
  M. Haupt, X. Zheng, Y. Kuang, et al., Stem Cells Transl. Med. 10 (2021) 357–373. doi: 10.1002/sctm.20-0086
107. [107]
  J. Yang, X. Zhang, X. Chen, et al., Mol. Ther. Nucleic Acids 7 (2017) 278–287. doi: 10.1016/j.omtn.2017.04.010
108. [108]
  F. Ferrantelli, C. Chiozzini, P. Leone, et al., Pharmaceutics 12 (2020) 529. doi: 10.3390/pharmaceutics12060529
109. [109]
  P. Scheltens, B. De Strooper, M. Kivipelto, et al., The Lancet 397 (2021) 1577. doi: 10.1016/S0140-6736(20)32205-4
110. [110]
  D. Liu, D. Fu, L. Zhang, et al., Chin. Chem. Lett. 32 (2021) 1066–1070. doi: 10.1016/j.cclet.2020.09.009
111. [111]
  J. Cao, M. Huang, L. Guo, et al., Mol. Psychiatry 26 (2021) 4687–4701. doi: 10.1038/s41380-020-0824-3
112. [112]
  N. Chopra, R. Wang, B. Maloney, et al., Mol. Psychiatry 26 (2021) 5636–5657. doi: 10.1038/s41380-019-0610-2
113. [113]
  A.T. Barros-Viegas, V. Carmona, E. Ferreiro, et al., Mol. Ther. Nucleic Acids 19 (2020) 1219–1236. doi: 10.1016/j.omtn.2020.01.010
114. [114]
  Y. Jahangard, H. Monfared, A. Moradi, et al., Front. Neurosci. 14 (2020) 564. doi: 10.3389/fnins.2020.00564
115. [115]
  H. Wei, Y. Xu, Q. Chen, et al., Cell Death Dis. 11 (2020) 290. doi: 10.1038/s41419-020-2490-4
116. [116]
  A.S. Aghabozorgi, N. Ahangari, T.E. Eftekhaari, et al., J. Cell Physiol. 234 (2019) 21796–21809. doi: 10.1002/jcp.28942
117. [117]
  W. Wang, N. Zhu, T. Yan, et al., Cell Commun. Signal 18 (2020) 119. doi: 10.1186/s12964-020-00581-2
118. [118]
  L. Wang, Q. Jia, C. Xinnong, et al., J. Cell Mol. Med. 23 (2019) 7124–7131. doi: 10.1111/jcmm.14562
119. [119]
  S. Sahoo, D.W. Losordo, Circ. Res. 114 (2014) 333–344. doi: 10.1161/CIRCRESAHA.114.300639
120. [120]
  M. Cheng, J. Yang, X. Zhao, et al., Nat. Commun. 10 (2019) 959. doi: 10.1038/s41467-019-08895-7
121. [121]
  F. Xu, J.Y. Zhong, X. Lin, et al., J. Pineal. Res. 68 (2020) e12631.
122. [122]
  N. Zhang, J. Zhu, Q. Ma, et al., Stem Cell Res. Ther. 11 (2020) 273. doi: 10.1186/s13287-020-01782-9
123. [123]
  Y. Song, C. Zhang, J. Zhang, et al., Theranostics 9 (2019) 2346–2360. doi: 10.7150/thno.29945
124. [124]
  Z. Wen, Z. Mai, X. Zhu, et al., Stem Cell Res. Ther. 11 (2020) 36. doi: 10.1186/s13287-020-1563-8
125. [125]
  T.M. Ribeiro-Rodrigues, T.L. Laundos, R. Pereira-Carvalho, et al., Cardiovasc. Res. 113 (2017) 1338–1350. doi: 10.1093/cvr/cvx118
126. [126]
  C. Gollmann-Tepekoylu, L. Polzl, M. Graber, et al., Cardiovasc. Res. 116 (2020) 1226–1236. doi: 10.1093/cvr/cvz209
127. [127]
  S.W. Youn, Y. Li, Y.M. Kim, et al., Antioxidants (Basel) 8 (2019) 18. doi: 10.3390/antiox8010018
128. [128]
  N. Abbas, F. Perbellini, T. Thum, Basic. Res. Cardiol. 115 (2020) 52. doi: 10.1007/s00395-020-0816-0
129. [129]
  L.L. Wang, Y. Liu, J.J. Chung, et al., Nat. Biomed. Eng. 1 (2017) 983–992. doi: 10.1038/s41551-017-0157-y
130. [130]
  M. Khan, E. Nickoloff, T. Abramova, et al., Circ. Res. 117 (2015) 52–64. doi: 10.1161/CIRCRESAHA.117.305990
131. [131]
  X. Zhang, Y. Li, Y.E. Chen, et al., Nat. Commun. 7 (2016) 10376. doi: 10.1038/ncomms10376
132. [132]
  Y. Xiong, L. Chen, C. Yan, et al., J. Nanobiotechnology 18 (2020) 66. doi: 10.1186/s12951-020-00622-5
133. [133]
  S. Chen, Y. Tang, Y. Liu, et al., Cell Prolif. 52 (2019) e12669.
134. [134]
  H. Hu, L. Dong, Z. Bu, et al., J. Extracell. Vesicles 9 (2020) 1778883. doi: 10.1080/20013078.2020.1778883
135. [135]
  M. Zhai, Y. Zhu, M. Yang, et al., Adv. Sci. (Weinh) 7 (2020) 2001334. doi: 10.1002/advs.202001334
136. [136]
  L. Huang, J. Zhang, X. Liu, et al., Chin. Chem. Lett. 32 (2021) 234–238. doi: 10.1016/j.cclet.2020.11.046
137. [137]
  Y. Zhao, L. Meng, K. Zhang, et al., Chin. Chem. Lett. 32 (2021) 266–270. doi: 10.1016/j.cclet.2020.10.031
138. [138]
  X. Gao, Z. Xu, G. Liu, et al., Acta. Biomater. 119 (2021) 57–74. doi: 10.13173/centasiaj.64.1-2.0057
139. [139]
  K. Huang, G. Liu, Z. Gu, et al., Chin. Chem. Lett. 31 (2020) 3190–3194. doi: 10.1016/j.cclet.2020.07.002
140. [140]
  P.H.L. Tran, D. Xiang, T.T.D. Tran, et al., Adv. Mater. 32 (2020) e1904040. doi: 10.1002/adma.201904040
141. [141]
  Y. Zhang, J. Bi, J. Huang, et al., Int. J. Nanomedicine 15 (2020) 6917–6934. doi: 10.2147/ijn.s264498
1. [1]
  Gaojian Yang , Zhiyang Li , Rabia Usman , Zhu Chen , Yuan Liu , Song Li , Hui Chen , Yan Deng , Yile Fang , Nongyue He . DNA walker induced "signal on" fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer. Chinese Chemical Letters, 2025, 36(2): 109930-. doi: 10.1016/j.cclet.2024.109930
2. [2]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
3. [3]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
4. [4]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
5. [5]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
6. [6]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
7. [7]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
8. [8]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
9. [9]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
10. [10]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
11. [11]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
12. [12]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
13. [13]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
14. [14]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
15. [15]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
16. [16]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
17. [17]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
18. [18]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
19. [19]
  Ze Wang , Hao Liang , Annan Liu , Xingchen Li , Lin Guan , Lei Li , Liang He , Andrew K. Whittaker , Bai Yang , Quan Lin . Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer. Chinese Chemical Letters, 2025, 36(2): 109765-. doi: 10.1016/j.cclet.2024.109765
20. [20]
  Chenghao Ge , Peng Wang , Pei Yuan , Tai Wu , Rongjun Zhao , Rong Huang , Lin Xie , Yong Hua . Tuning hot carrier transfer dynamics by perovskite surface modification. Chinese Chemical Letters, 2024, 35(10): 109352-. doi: 10.1016/j.cclet.2023.109352

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1115)
HTML views(190)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142