Citation: Yupian Deng, Jingjing He, Song Cao, Xuhong Qian. Advances in cycloaddition and hydroaddition reaction of α-(trifluoromethyl)styrenes without defluorination: An alternative approach to CF₃-containing compounds[J]. Chinese Chemical Letters, ;2022, 33(5): 2363-2371. doi: 10.1016/j.cclet.2021.11.049 shu

Advances in cycloaddition and hydroaddition reaction of α-(trifluoromethyl)styrenes without defluorination: An alternative approach to CF₃-containing compounds

Yupian Deng ^a ,
Jingjing He ^a ,
Song Cao ^{a, *,} ,
Xuhong Qian ^{a, b, *,}

a.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai 200237, China
b.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China

scao@ecust.edu.cn

xhqian@ecust.edu.cn

Received Date: 11 September 2021
Revised Date: 10 November 2021
Accepted Date: 14 November 2021
Available Online: 19 November 2021

Figures(43)

α-(Trifluoromethyl)styrene and its derivatives have found wide applications in the fields of pharmaceuticals, agrochemicals, and advanced materials. They are also versatile trifluoromethyl-containing building blocks for the preparation of various trifluoromethyl-containing, fluorine-containing or nonfluorinated compounds. Recently, great efforts have been made to develop diverse reactions for rapidly accessing a wide range of valuable gem-difluoroalkenes and gem-difluoroalkylated compounds via defluorinative reaction or the defluorinative ipso-functionalization reaction of α-(trifluoromethyl)styrenes, respectively. In contrast, α-(trifluoromethyl)styrenes remain notably underdeveloped with respect to their use in cycloaddition and hydroaddition reaction with retaining of three CF bonds. This short review herein is aimed to summarize the recent progress on the cycloaddition and hydroaddition reaction including nucleophilic, radical and transition metal-catalyzed addition of α-(trifluoromethyl)styrenes without accompanying defluorination.
- α-(Trifluoromethyl)styrenes,
- Cycloaddition and hydroaddition,
- Nondefluorination,
- CF₃-containing compounds
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Advances in cycloaddition and hydroaddition reaction of α-(trifluoromethyl)styrenes without defluorination: An alternative approach to CF3-containing compounds

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通讯作者: 陈斌, bchen63@163.com

Advances in cycloaddition and hydroaddition reaction of α-(trifluoromethyl)styrenes without defluorination: An alternative approach to CF₃-containing compounds