Citation: Chenglong Cai, Ting Wang, Xu Han, Shaoqiang Yang, Chengteng Lai, Tao Yuan, Zhangqi Feng, Nongyue He. In situ wound sprayable double-network hydrogel: Preparation and characterization[J]. Chinese Chemical Letters, ;2022, 33(4): 1963-1969. doi: 10.1016/j.cclet.2021.11.047 shu

In situ wound sprayable double-network hydrogel: Preparation and characterization

Chenglong Cai ^{a, b, 1} ,
Ting Wang ^{a, b, 1,} ,
Xu Han ^a ,
Shaoqiang Yang ^c ,
Chengteng Lai ^c ,
Tao Yuan ^{c, *,} ,
Zhangqi Feng ^d ,
Nongyue He ^a

a.
State Key Laboratory of Bioelectronics, National Demonstration Centre for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
b.
Southeast University Jiangbei New Area Innovation Institute, Nanjing 210096, China
c.
Nanjing Jinling Hosp, Dept Orthoped, Nanjing 210002, China
d.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

tingwang@seu.edu.cn

yuant1205@163.com

Received Date: 26 July 2021
Revised Date: 13 November 2021
Accepted Date: 15 November 2021
Available Online: 19 November 2021

Figures(4)

In clinical settings the wound-dressing was required easy to use and can match the wound area immediately, at the same time they need to have the properties of hemostats, anti-inflammation and promoting wound healing. To get an ideal wound dressing, we developed a type of gel-like wound adhesive patch from spraying double-network hydrogel, which own the properties of self-antibacterial and can promote wound healing. By spraying, the gel-like wound adhesive patch can match the wound area immediately and form a gel-film in 10 s. Sodium carboxymethyl cellulose as pH sensitive materials accelerated the speed to form the gel-film and enhanced ductility of the wound adhesive patch. In vitro experiments show that, this gel-like wound adhesive patch can promote cell proliferation and reduce cell apoptosis. In vivo studies show that, compared with commercialized wound dressings in clinic using, the spraying gel-like wound adhesive patch from our work has a better effect on wound healing. In conclusion, the spraying gel-like wound patch in our work is easy to use and can form a gel-film match on wound area in a short time, also it has the properties of hemostats, anti-inflammation and promoting wound healing. Its feasibility for mass production shows a good potential for commercial use.
- Hydrogel,
- Sodium alginate,
- Chitosan,
- Spray method,
- Sodium carboxymethyl cellulose
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