Citation: Qian Wang, Zhiliang Gao, Kaijie Zhao, Peiyu Zhang, Qi-Zhi Zhong, Qun Yu, Shumei Zhai, Jiwei Cui. Co-delivery of enzymes and photosensitizers via metal-phenolic network capsules for enhanced photodynamic therapy[J]. Chinese Chemical Letters, ;2022, 33(4): 1917-1922. doi: 10.1016/j.cclet.2021.11.040 shu

Co-delivery of enzymes and photosensitizers via metal-phenolic network capsules for enhanced photodynamic therapy

Qian Wang ^a ,
Zhiliang Gao ^a ,
Kaijie Zhao ^a ,
Peiyu Zhang ^a ,
Qi-Zhi Zhong ^{a, b} ,
Qun Yu ^{a, *,} ,
Shumei Zhai ^{a, *,} ,
Jiwei Cui ^{a, c}

a.
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, China
b.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, The University of Melbourne, Parkville, VIC 3010, United States
c.
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China

qunyu@sdu.edu.cn

smzhai@sdu.edu.cn

Received Date: 31 August 2021
Revised Date: 10 November 2021
Accepted Date: 12 November 2021
Available Online: 18 November 2021

Figures(5)

The intrinsic hypoxic tumor microenvironment and limited accumulation of photosensitizers (PSs) result in unsatisfied efficiency of photodynamic therapy (PDT). To enhance the PDT efficiency against solid tumors, a functional oxygen self-supplying and PS-delivering nanosystem is fabricated via the combination of catalase (CAT), chlorin e6 (Ce6) and metal-phenolic network (MPN) capsule. It is demonstrated that the CAT encapsulated in the capsules (named CCM capsules) could catalyze the degradation of hydrogen peroxide (H₂O₂) to produce molecular oxygen (O₂), which could be converted into cytotoxicity reactive oxygen species (ROS) by surface-loaded Ce6 under 660 nm laser irradiation, leading to synergistic anticancer effects in vitro and in vivo. Therefore, the application of CCM capsule could be a promising strategy to improve PDT effectiveness.
- Metal-phenolic network (MPN),
- Photodynamic therapy (PDT),
- Capsule,
- Oxygen self-supply,
- Drug delivery
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