Citation: Jiayi Zhu, Ai Ouyang, Zhuanglin Shen, Zhihao Pan, Samya Banerjee, Qianling Zhang, Yantao Chen, Pingyu Zhang. Sonodynamic cancer therapy by novel iridium-gold nanoassemblies[J]. Chinese Chemical Letters, ;2022, 33(4): 1907-1912. doi: 10.1016/j.cclet.2021.11.017 shu

Sonodynamic cancer therapy by novel iridium-gold nanoassemblies

Jiayi Zhu ^{a, b} ,
Ai Ouyang ^a ,
Zhuanglin Shen ^a ,
Zhihao Pan ^a ,
Samya Banerjee ^c ,
Qianling Zhang ^a ,
Yantao Chen ^a ,
Pingyu Zhang ^{a, *,}

a.
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
b.
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
c.
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, UP 221005, India

p.zhang6@szu.edu.cn

Received Date: 16 August 2021
Revised Date: 1 November 2021
Accepted Date: 3 November 2021
Available Online: 11 November 2021

Figures(6)

Metal-based compounds with excellent photo-physical properties show good photochemotherapeutic performance. But, low in-depth tissue penetration of light limits their effectivity for deeply buried tumors. Encouraged by the sonosensitizing ability of the traditional organic photosensitizers, here, we developed AuNPs@Ir1 as a sonosensitizer by hybridizing an organometallic Ir(Ⅲ) complex (Ir1) with ultrasmall gold nanoparticles (AuNPs) for efficient tumor sonodynamic therapy (SDT) for the first time. AuNPs@Ir1 rapidly entered the cancer cells, produced ¹O₂, and catalytically oxidized NADH to NAD⁺ under ultrasound (US) irradiation, thus resulted in cancer cells oncosis. Because of efficient passive retention in tumors post intravenous injection, AuNPs@Ir1 further efficiently inhibited the growth of tumors in-vivo under US stimulation without long-term toxicity to other organs. Overall, this work presents the excellent US triggered in-vitro and in-vivo anticancer profile of the novel AuNPs@Ir1. It is expected to increase the scope of SDT for metal-based anticancer drugs.
- Metals in medicine,
- Iridium complex,
- Sonocatalysis,
- Sonodynamic therapy,
- Bioinorganic chemistry
1. [1]
  R.L. Siegel, K.D. Miller, A. Jemal, CA-Cancer J. Clin. 69 (2019) 7-34. doi: 10.3322/caac.21551
2. [2]
  S. Liang, X. Deng, P. Ma, et al., Adv. Mater. 32 (2020) e2003214. doi: 10.1002/adma.202003214
3. [3]
  H.Z. Deng, Z.J. Zhou, W.J. Yang, et al., Nano Lett. 20 (2020) 1928-1933. doi: 10.1021/acs.nanolett.9b05210
4. [4]
  L.S. Lin, J.B. Song, L. Song, et al., Angew. Chem. Int. Ed. 57 (2018) 4902-4906. doi: 10.1002/anie.201712027
5. [5]
  H. Chen, Z. Liu, O. Jiang, et al., Giant 8 (2021) 100073. doi: 10.1016/j.giant.2021.100073
6. [6]
  A. Grzybowski, K. Pietrzak, Clin. Dermatol. 30 (2012) 451-455. doi: 10.1016/j.clindermatol.2011.11.019
7. [7]
  D. Dolmans, D. Fukumura, R.K. Jain, Nat. Rev. Cancer 3 (2003) 380-387. doi: 10.1038/nrc1071
8. [8]
  S. Monro, K.L. Colon, H.M. Yin, et al., Chem. Rev. 119 (2019) 797-828. doi: 10.1021/acs.chemrev.8b00211
9. [9]
  C. Li, Y. Wang, Y. Lu, et al., Chin. Chem. Lett. 31 (2020) 1183-1187. doi: 10.1016/j.cclet.2019.09.034
10. [10]
  L. Shen, T. Zhou, Y. Fan, et al., Chin. Chem. Lett. 31 (2020) 1709-1716. doi: 10.1016/j.cclet.2020.02.007
11. [11]
  D.F. Costa, L.P. Mendes, V.P. Torchilin, Adv. Drug Deliv. Rev. 138 (2019) 105-116. doi: 10.1016/j.addr.2018.09.004
12. [12]
  S. Kuang, L. Sun, X. Zhang, et al., Angew. Chem. Int. Ed. 59 (2020) 20697-20703. doi: 10.1002/anie.202009888
13. [13]
  J. Karges, S. Kuang, F. Maschietto, et al., Nat. Commun. 11 (2020) 3262. doi: 10.1038/s41467-020-16993-0
14. [14]
  F. Heinemann, J. Karges, G. Gasser, Acc. Chem. Res. 50 (2017) 2727-2736. doi: 10.1021/acs.accounts.7b00180
15. [15]
  J. Hess, H.Y. Huang, A. Kaiser, et al., Chem. Eur. J. 23 (2017) 9888-9896. doi: 10.1002/chem.201701392
16. [16]
  N. Yumita, Y. Iwase, K. Nishi, et al., Theranostics 2 (2012) 880-888. doi: 10.7150/thno.3899
17. [17]
  P. Huang, X. Qian, Y. Chen, et al., J. Am. Chem. Soc. 139 (2017) 1275-1284. doi: 10.1021/jacs.6b11846
18. [18]
  X. Pan, W. Wang, Z. Huang, et al., Angew. Chem. Int. Ed. 59 (2020) 13557-13561. doi: 10.1002/anie.202004894
19. [19]
  X. Qian, Y. Zheng, Y. Chen, Adv. Mater. 28 (2016) 8097-8129. doi: 10.1002/adma.201602012
20. [20]
  F. Gong, L. Cheng, N. Yang, et al., Nat. Commun. 11 (2020) 3712. doi: 10.1038/s41467-020-17485-x
21. [21]
  X. Wang, X. Zhong, L. Bai, et al., J. Am. Chem. Soc. 142 (2020) 6527-6537. doi: 10.1021/jacs.9b10228
22. [22]
  C. Imberti, P. Zhang, H. Huang, et al., Angew. Chem. Int. Ed. 59 (2020) 61-73. doi: 10.1002/anie.201905171
23. [23]
  X. Wang, X. Wang, S. Jin, et al., Chem. Rev. 119 (2019) 1138-1192. doi: 10.1021/acs.chemrev.8b00209
24. [24]
  C. Jin, F. Liang, J. Wang, et al., Angew. Chem. Int. Ed. 59 (2020) 15987-15991. doi: 10.1002/anie.202006964
25. [25]
  L. Hao, Z.W. Li, D.Y. Zhang, et al., Chem. Sci. 10 (2019) 1285-1293. doi: 10.1039/C8SC04242J
26. [26]
  P.Y. Zhang, C.K.C. Chiu, H.Y. Huang, et al., Angew. Chem. Int. Ed. 56 (2017) 14898-14902. doi: 10.1002/anie.201709082
27. [27]
  H. Huang, S. Banerjee, K. Qiu, et al., Nat. Chem. 11 (2019) 1041. doi: 10.1038/s41557-019-0328-4
28. [28]
  C. Huang, C. Liang, T. Sadhukhan, et al., Angew. Chem. Int. Ed. 60 (2021) 9474-9479. doi: 10.1002/anie.202015671
29. [29]
  Q. Yang, H. Jin, Y. Gao, et al., ACS Appl. Mater. Interfaces 11 (2019) 15417-15425. doi: 10.1021/acsami.9b04098
30. [30]
  S. Yi, Z. Lu, J. Zhang, et al., ACS Appl. Mater. Interfaces 11 (2019) 15276-15289. doi: 10.1021/acsami.9b01205
31. [31]
  S.M. King, S. Claire, R.I. Teixeira, et al., J. Am. Chem. Soc. 140 (2018) 10242-10249. doi: 10.1021/jacs.8b05105
32. [32]
  P. Zhang, J. Wang, H. Huang, et al., Biomaterials 35 (2014) 9003-9011. doi: 10.1016/j.biomaterials.2014.07.021
33. [33]
  J. Xie, C. Liang, S. Luo, et al., ACS Appl. Mater. Interfaces 13 (2021) 27934-27944. doi: 10.1021/acsami.1c06381
34. [34]
  N. Kong, X. Ji, J. Wang, et al., Nano Lett. 20 (2020) 3943-3955. doi: 10.1021/acs.nanolett.0c01098
35. [35]
  J. Huang, X. You, P. Xin, et al., Chin. Chem. Lett. 32 (2021) 1737-1742. doi: 10.1016/j.cclet.2020.12.006
36. [36]
  Y. Tan, K. He, B. Tang, et al., ACS Nano 14 (2020) 13975-13985. doi: 10.1021/acsnano.0c06388
37. [37]
  Y. Chen, L. Li, L. Gong, et al., Adv. Funct. Mater. 29 (2019) 1806945. doi: 10.1002/adfm.201806945
38. [38]
  J. Liu, M. Yu, C. Zhou, et al., J. Am. Chem. Soc. 135 (2013) 4978-4981. doi: 10.1021/ja401612x
39. [39]
  C. Peng, J. Xu, M. Yu, et al., Angew. Chem. Int. Ed. 58 (2019) 8479-8483. doi: 10.1002/anie.201903256
40. [40]
  C. Peng, M. Yu, J.T. Hsieh, et al., Angew. Chem. Int. Ed. 58 (2019) 12076-12080. doi: 10.1002/anie.201905738
41. [41]
  Y. Lei, L. Tang, Y. Xie, et al., Nat. Commun. (2017) 15130.
42. [42]
  Y. Sun, D. Wang, Y. Zhao, et al., Nano Res. 11 (2018) 2392-2404. doi: 10.1007/s12274-017-1860-4
43. [43]
  P. Zhang, H. Huang, S. Banerjee, et al., Angew. Chem. Int. Ed. 58 (2019) 2350-2354. doi: 10.1002/anie.201813002
44. [44]
  Y. Wang, H. Huang, G. Chen, et al., Chem. Commun. 54 (2018) 3282-3285. doi: 10.1039/C8CC01597J
45. [45]
  J. Xie, Y. Zheng, J.Y. Ying, J. Am. Chem. Soc. 131 (2009) 888-889. doi: 10.1021/ja806804u
46. [46]
  D. Segets, R. Marczak, S. Schäfer, et al., ACS Nano 5 (2011) 4658-4669. doi: 10.1021/nn200465b
47. [47]
  J. Zhao, J. Fei, C. Du, et al., Chem. Commun. 49 (2013) 10733-10735. doi: 10.1039/c3cc46969g
48. [48]
  K.Y. Lu, P.Y. Lin, E.Y. Chuang, et al., ACS Appl. Mater. Interfaces 9 (2017) 5158-5172. doi: 10.1021/acsami.6b15515
49. [49]
  H.M. Dao, I. Husain, V.K. Shankar, et al., Chem. Commun. 56 (2020) 12017-12020. doi: 10.1039/D0CC05204C
50. [50]
  J.F. Turrens, A. Boveris, Biochem. J. 191 (1980) 421-427. doi: 10.1042/bj1910421
51. [51]
  S. Rajagopalan, S. Kurz, T. Munzel, et al., J. Clin. Invest. 97 (1996) 1916-1923. doi: 10.1172/JCI118623
52. [52]
  Z. Liu, R.J. Deeth, J.S. Butler, et al., Angew. Chem. Int. Ed. 52 (2013) 4194-4197. doi: 10.1002/anie.201300747
53. [53]
  S. Betanzos-Lara, Z. Liu, A. Habtemariam, et al., Angew. Chem. Int. Ed. 51 (2012) 3897-3900. doi: 10.1002/anie.201108175
54. [54]
  V.G. Deepagan, D.G. You, W. Um, et al., Nano Lett. 16 (2016) 6257-6264. doi: 10.1021/acs.nanolett.6b02547
55. [55]
  Y. Cao, T. Wu, W. Dai, H. Dong, X. Zhang, Chem. Mater. 31 (2019) 9105-9114. doi: 10.1021/acs.chemmater.9b03430
56. [56]
  F. Gao, G. He, H. Yin, et al., Nanoscale 11 (2019) 2374-2384. doi: 10.1039/C8NR07188H
57. [57]
  J. Ouyang, L. Deng, W. Chen, et al., Chem. Commun. 54 (2018) 2874-2877. doi: 10.1039/C8CC00392K
1. [1]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
2. [2]
  Fuzheng Zhang , Chao Shi , Jiale Li , Fulin Jia , Xinyu Liu , Feiyang Li , Xinyu Bai , Qiuxia Li , Aihua Yuan , Guohua Xie . B-embedded narrowband pure near-infrared (NIR) phosphorescent iridium(Ⅲ) complexes and solution-processed OLED application. Chinese Chemical Letters, 2025, 36(1): 109596-. doi: 10.1016/j.cclet.2024.109596
3. [3]
  Lihua Ma , Song Guo , Zhi-Ming Zhang , Jin-Zhong Wang , Tong-Bu Lu , Xian-Shun Zeng . Sensitizing photoactive metal–organic frameworks via chromophore for significantly boosting photosynthesis. Chinese Chemical Letters, 2024, 35(5): 108661-. doi: 10.1016/j.cclet.2023.108661
4. [4]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
5. [5]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
6. [6]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
7. [7]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
8. [8]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
9. [9]
  Hong Yin , Zhipeng Yu . Hexavalent iridium catalyst enhances efficiency of hydrogen production. Chinese Journal of Structural Chemistry, 2025, 44(1): 100382-100382. doi: 10.1016/j.cjsc.2024.100382
10. [10]
  Wei Chen , Pieter Cnudde . A minireview to ketene chemistry in zeolite catalysis. Chinese Journal of Structural Chemistry, 2024, 43(11): 100412-100412. doi: 10.1016/j.cjsc.2024.100412
11. [11]
  Peiwen Liu , Fang Zhao , Jing Zhang , Yunpeng Bai , Jinxing Ye , Bo Bao , Xinggui Zhou , Li Zhang , Changlu Zhou , Xinhai Yu , Peng Zuo , Jianye Xia , Lian Cen , Yangyang Yang , Guoyue Shi , Lin Xu , Weiping Zhu , Yufang Xu , Xuhong Qian . Micro/nano flow chemistry by Beyond Limits Manufacturing. Chinese Chemical Letters, 2024, 35(5): 109020-. doi: 10.1016/j.cclet.2023.109020
12. [12]
  Xin Li , Zhen Xu , Donglei Bu , Jinming Cai , Huamei Chen , Qi Chen , Ting Chen , Fang Cheng , Lifeng Chi , Wenjie Dong , Zhenchao Dong , Shixuan Du , Qitang Fan , Xing Fan , Qiang Fu , Song Gao , Jing Guo , Weijun Guo , Yang He , Shimin Hou , Ying Jiang , Huihui Kong , Baojun Li , Dengyuan Li , Jie Li , Qing Li , Ruoning Li , Shuying Li , Yuxuan Lin , Mengxi Liu , Peinian Liu , Yanyan Liu , Jingtao Lü , Chuanxu Ma , Haoyang Pan , JinLiang Pan , Minghu Pan , Xiaohui Qiu , Ziyong Shen , Shijing Tan , Bing Wang , Dong Wang , Li Wang , Lili Wang , Tao Wang , Xiang Wang , Xingyue Wang , Xueyan Wang , Yansong Wang , Yu Wang , Kai Wu , Wei Xu , Na Xue , Linghao Yan , Fan Yang , Zhiyong Yang , Chi Zhang , Xue Zhang , Yang Zhang , Yao Zhang , Xiong Zhou , Junfa Zhu , Yajie Zhang , Feixue Gao , Yongfeng Wang . Recent progress on surface chemistry Ⅰ: Assembly and reaction. Chinese Chemical Letters, 2024, 35(12): 110055-. doi: 10.1016/j.cclet.2024.110055
13. [13]
  Xin Li , Zhen Xu , Donglei Bu , Jinming Cai , Huamei Chen , Qi Chen , Ting Chen , Fang Cheng , Lifeng Chi , Wenjie Dong , Zhenchao Dong , Shixuan Du , Qitang Fan , Xing Fan , Qiang Fu , Song Gao , Jing Guo , Weijun Guo , Yang He , Shimin Hou , Ying Jiang , Huihui Kong , Baojun Li , Dengyuan Li , Jie Li , Qing Li , Ruoning Li , Shuying Li , Yuxuan Lin , Mengxi Liu , Peinian Liu , Yanyan Liu , Jingtao Lü , Chuanxu Ma , Haoyang Pan , JinLiang Pan , Minghu Pan , Xiaohui Qiu , Ziyong Shen , Qiang Sun , Shijing Tan , Bing Wang , Dong Wang , Li Wang , Lili Wang , Tao Wang , Xiang Wang , Xingyue Wang , Xueyan Wang , Yansong Wang , Yu Wang , Kai Wu , Wei Xu , Na Xue , Linghao Yan , Fan Yang , Zhiyong Yang , Chi Zhang , Xue Zhang , Yang Zhang , Yao Zhang , Xiong Zhou , Junfa Zhu , Yajie Zhang , Feixue Gao , Li Wang . Recent progress on surface chemistry Ⅱ: Property and characterization. Chinese Chemical Letters, 2025, 36(1): 110100-. doi: 10.1016/j.cclet.2024.110100
14. [14]
  Yingxiao Zong , Yangfei Wei , Xiaoqing Liu , Junke Wang , Huanfang Guo , Junli Wang , Zhuangzhi Shi , Tao Tu , Cheng Yang , Chongyang Wang , Leyong Wang . The 4^th CCL Organic Chemistry Forum held in Zhangye. Chinese Chemical Letters, 2024, 35(8): 109743-. doi: 10.1016/j.cclet.2024.109743
15. [15]
  Haiying Lu , Weijie Li . The electrolyte solvation and interfacial chemistry for anode-free sodium metal batteries. Chinese Journal of Structural Chemistry, 2024, 43(11): 100334-100334. doi: 10.1016/j.cjsc.2024.100334
16. [16]
  Xiumei LI , Yanju HUANG , Bo LIU , Yaru PAN . Syntheses, crystal structures, and quantum chemistry calculation of two Ni(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2031-2039. doi: 10.11862/CJIC.20240109
17. [17]
  Bingwei Wang , Yihong Ding , Xiao Tian . Benchmarking model chemistry composite calculations for vertical ionization potential of molecular systems. Chinese Chemical Letters, 2025, 36(2): 109721-. doi: 10.1016/j.cclet.2024.109721
18. [18]
  Chun-Yun Ding , Ru-Yuan Zhang , Yu-Wu Zhong , Jiannian Yao . Binary and heterostructured microplates of iridium and ruthenium complexes: Preparation, characterization, and thermo-responsive emission. Chinese Journal of Structural Chemistry, 2024, 43(10): 100393-100393. doi: 10.1016/j.cjsc.2024.100393
19. [19]
  Chao Ma , Cong Lin , Jian Li . MicroED as a powerful technique for the structure determination of complex porous materials. Chinese Journal of Structural Chemistry, 2024, 43(3): 100209-100209. doi: 10.1016/j.cjsc.2023.100209
20. [20]
  Yuanjin Chen , Xianghui Shi , Dajiang Huang , Junnian Wei , Zhenfeng Xi . Synthesis and reactivity of cobalt dinitrogen complex supported by nonsymmetrical pincer ligand. Chinese Chemical Letters, 2024, 35(7): 109292-. doi: 10.1016/j.cclet.2023.109292

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(928)
HTML views(71)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142