Citation: Yun-Chang Zhang, Lan She, Zi-Yue Xu, Ze-Kun Wang, Zhiqiang Ma, Feng Yang, Zhan-Ting Li. A BODIPY-modified polymeric micelle for sustaining enhanced photodynamic therapy[J]. Chinese Chemical Letters, ;2022, 33(6): 3277-3280. doi: 10.1016/j.cclet.2021.11.004 shu

A BODIPY-modified polymeric micelle for sustaining enhanced photodynamic therapy

Yun-Chang Zhang ^{a, 1} ,
Lan She ^{a, 1,} ,
Zi-Yue Xu ^{b, 1} ,
Ze-Kun Wang ^b ,
Zhiqiang Ma ^a ,
Feng Yang ^{a, *,} ,
Zhan-Ting Li ^{b, *,}

a.
Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China
b.
Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China

slgs4100@126.com

yangfeng1008@126.com

ztli@fudan.edu.cn

Received Date: 15 September 2021
Revised Date: 20 October 2021
Accepted Date: 1 November 2021
Available Online: 7 November 2021

Figures(5)

Photodynamic therapy (PDT) has been gaining popularity in both scientific research and clinic applications due to its non-invasiveness and spatiotemporal targeting properties. Nevertheless, the local hypoxic microenvironment in tumor tissue impedes PDT universality. To overcome this drawback, a 2-pyridone-bearing BODIPY photosensitizer was synthesized rationally and introduced to polyethyleneglycol-b-poly(aspartic acid) to form a photosensitizer-¹O₂ generation, storage/release agent dual-loading system (PEG-b-PAsp-BODIPY). The investigation of the PDT effect at different illumination conditions in vitro and in vivo revealed that the system tremendously inhibited tumor proliferation, indicating that this new PEG-b-PAsp-BODIPY could act as a potentially effective photo therapeutic system for cancer therapeutics.
- Photodynamic therapy,
- Polymeric micelle,
- BODIPY,
- 2-Pyridone,
- Tumor
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