Citation: Keqing Huang, Jun Huang, Jinmin Zhao, Zhipeng Gu, Jun Wu. Natural lotus root-based scaffolds for bone regeneration[J]. Chinese Chemical Letters, ;2022, 33(4): 1941-1945. doi: 10.1016/j.cclet.2021.10.073 shu

Natural lotus root-based scaffolds for bone regeneration

Keqing Huang ^{a, b, 1} ,
Jun Huang ^{f, 1} ,
Jinmin Zhao ^{c, *,} ,
Zhipeng Gu ^{d, e, **,} ,
Jun Wu ^{a, b, ***,}

a.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
b.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
c.
Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
d.
Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen 518057, China
e.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
f.
Guangdong Academy of Sciences, Institute of Biological and Medical Engineering, Guangzhou 510316, China

^**

^***

gxzj1962@163.com

guzhipeng2019@scu.edu.cn

wujun29@mail.sysu.edu.cn

Received Date: 28 July 2021
Revised Date: 21 October 2021
Accepted Date: 26 October 2021
Available Online: 29 October 2021

Figures(4)

A high incidence of bone defects and the limitation of autologous bone grafting require 3D scaffolds for bone repair. Compared with synthetic materials, natural edible materials possess outstanding advantages in terms of biocompatibility, bioactivities and low manufacturing cost for bone tissue engineering. In this work, attracted by the natural porous/fabric structure, good biocompatibility and bioactivities of the lotus root, the lotus root-based scaffolds were fabricated and investigated their potential to serve as natural porous bone tissue engineering scaffolds. The results indicated that the lotus root-based scaffolds possess suitable natural microstructure, excellent biocompatibility and promising functions, such as antioxidant capacity and angiogenesis promotion. Remarkably, lotus root scaffolds showed encouraging possibility of bone tissue engineering while the mineralized lotus root could further improve the bone regeneration in vivo. All the results demonstrated the bone regeneration potential of lotus root-based scaffolds equipped with suitable natural architecture, excellent biocompatibility, specific bioactivities and low manufacturing cost.
- Bone regeneration,
- Lotus root,
- Porous structure,
- Mineralization
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