Citation: Yan Jiang, Ren-Yong Yang, Zhao-Xia Qu, Gui-Ge Hou, Wei Cong, Chun-Hua Wang, Feng Zhao. Valeriaquinone A, a unique anthraquinone-coumarin hybrid with selective inhibition of PTP1B from Knoxia valerianoides[J]. Chinese Chemical Letters, ;2022, 33(6): 2919-2922. doi: 10.1016/j.cclet.2021.10.072 shu

Valeriaquinone A, a unique anthraquinone-coumarin hybrid with selective inhibition of PTP1B from Knoxia valerianoides

The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai 264003, China

zhaofeng2015@163.com

Received Date: 5 September 2021
Revised Date: 12 October 2021
Accepted Date: 25 October 2021
Available Online: 30 October 2021

Figures(5)

Valeriaquinone A (1), an unprecedented anthraquinone-coumarin hybrid, was isolated from the roots of Knoxia valerianoides. Its structure was determined by extensive spectroscopic analyses and X-ray diffraction. The plausible biosynthetic pathways for 1 were proposed. Compound 1 exhibited strong protein tyrosine phosphatase 1B (PTP1B) inhibition with high selectivity (> 30 fold) over homologous T cell protein tyrosine phosphatase (TCPTP) potentially by binding to an allosteric site predicted by kinetic analysis and molecular docking. Moreover, compound 1 showed significant cytotoxic activities against three human hepatoma cell lines (HepG2, QGY-7703, and SMMC-7721) with half maximal inhibitory concentration (IC₅₀) values of 1.39 ± 0.2, 10.34 ± 2.09, and 5.56 ± 0.47 µmol/L, respectively.
- Knoxia valerianoides,
- Anthraquinone-coumarin hybrid,
- PTP1B inhibitory activity,
- Cytotoxic activity,
- Allosteric inhibition
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